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Bitertanol

Bitertanol structure

CAS No.: 55179-31-2

Chemical Name:: Bitertanol

Synonyms: BAYCOR;kwg0599;SIBUTOL;R 33986;Baycoral;(1RS,2RS;Biloxuron;biloxazol;BAYMAT(R);AI3-27699

CBNumber:: CB8442457

Molecular Formula:: C20H23N3O2

Molecular Weight:: 337.42

MDL Number:: MFCD00055508

MOL File:: 55179-31-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-22 18:57:36

Product description	Number	Pack Size	Price
Bitertanol mixture of diastereo isomers	45349	250mg	$36.5
Bitertanol	B6034	1G	$132
Bitertanol	B6034	5G	$394
Bitertanol ≥98%	24054	250mg	$107
Bitertanol ≥98%	24054	500mg	$204
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Bitertanol Properties

Melting point	49-50°C
Boiling point	350°C
Density	1.1676 (rough estimate)
vapor pressure	A 2.2 x l0^-10 (20 °C) B 2.5 x l0^-9 (20 °C)
refractive index	1.6200 (estimate)
Flash point	100 °C
storage temp.	2-8°C
solubility	Chloroform: slightl soluble,DMSO: Slightly Soluble,Methanol: Slightly Soluble
Water Solubility	A 2.7 mg l^-1 (20 °C) B 1.1 mg l^-1 (20 °C)
pka	13.40±0.20(Predicted)
Merck	13,1301
BRN	620948
Henry's Law Constant	1.2×10⁴ mol/(m³Pa) at 25℃, Mackay et al. (2006)
InChI	InChI=1S/C20H23N3O2/c1-20(2,3)18(24)19(23-14-21-13-22-23)25-17-11-9-16(10-12-17)15-7-5-4-6-8-15/h4-14,18-19,24H,1-3H3
InChIKey	VGPIBGGRCVEHQZ-UHFFFAOYSA-N
SMILES	C(N1N=CN=C1)(C(O)C(C)(C)C)OC1C=CC(C2C=CC=CC=2)=CC=1
FDA UNII	GR7Z3Z59G9
NIST Chemistry Reference	1H-1,2,4-triazole-1-ethanol, «beta»-([1,1'-biphenyl]-4-yloxy)-«alpha»-(1,1-dimethylethyl)-(55179-31-2)
Pesticides Freedom of Information Act (FOIA)	Baycor
EPA Substance Registry System	Bitertanol (55179-31-2)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

Hazard Codes

Risk Statements

22-23

Safety Statements

RIDADR

UN 2811

WGK Germany

RTECS

XZ4803050

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

Toxicity

LD50 in rats, male and female mice (mg/kg): >5000, 4488, 4202 orally (Brandes)

NFPA 704

	0
4		0

Bitertanol price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	45349	Bitertanol mixture of diastereo isomers	55179-31-2	250mg	$36.5	2022-05-15	Buy
TCI Chemical	B6034	Bitertanol	55179-31-2	1G	$132	2026-04-30	Buy
TCI Chemical	B6034	Bitertanol	55179-31-2	5G	$394	2026-04-30	Buy
Cayman Chemical	24054	Bitertanol ≥98%	55179-31-2	250mg	$107	2026-04-30	Buy
Cayman Chemical	24054	Bitertanol ≥98%	55179-31-2	500mg	$204	2026-04-30	Buy

Product number	Packaging	Price	Buy
45349	250mg	$36.5	Buy
B6034	1G	$132	Buy
B6034	5G	$394	Buy
24054	250mg	$107	Buy
24054	500mg	$204	Buy

Bitertanol Chemical Properties,Uses,Production

Description

Bitertanol is a broad-spectrum triazole fungicide that is active against a variety of fungi, including V. inaequalis and V. pirina, which are responsible for apple and pear scab, respectively, as well as S. mors-uvae and P. ribis, which are responsible for American gooseberry mildew and leaf spot in black currants, respectively. It is active against isolates of V. inaequalis (MICs = 0.6 and 1 μg/ml) but repeated use leads to resistance and cross-resistance (MICs = 9.8-13 μg/ml for bitertanol-resistant isolates). Bitertanol inhibits the cytochrome P450 (CYP450) isoform CYP3A4 (IC₅₀ = 2.74 μM) and inhibits androgenic activity induced by the androgen receptor agonist DHT in a yeast two-hybrid assay (IC₅₀ = 79.85 μM). In rats, bitertanol (10-300 mg/kg, i.p.) increases operant responding on one- and five-minute fixed interval schedules with no effect on motor activity.

Chemical Properties

White Solid

Uses

Agricultural fungicide.

Uses

Bitertanol is used as a seed treatment on winter wheat and barley and as a foliar treatment to control diseases on bananas, ornamentals, fruit and vegetables.

Uses

Bitertanol is a foliar-applied triazole fungicide used to protect tropical and subtropical crops in agriculture, in particular bananas. Bitertanol has effects on behavior that are similar to those of psychomotor stimulants.

Definition

ChEBI: 1-(biphenyl-4-yloxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-ol is a member of the class of triazoles that is 3,3-dimethyl-1-(1,2,4-triazol-1-yl)butane-1,2-diol substituted at position O-1 by a biphenyl-4-yl group. It is a member of biphenyls, an aromatic ether, a member of triazoles and a secondary alcohol.

Agricultural Uses

Fungicide: A fungicide used to control a variety of diseases. Used as control for prunes when drying. Not currently registered in the U.S. or EU countries (pending). Used in many European, South American, Far Eastern and African countries, a well as in Australia for use on beans (all types) and various ornamentals. More than 20 global suppliers.

Trade name

BAYCOR®; BAY KWG 0599®; BAYMATSPRAY ®; BILOXAZOL®; KWG 0599®; SIBUTOL®, (with Fuberidazole)

Metabolic pathway

Bitertanol is a mixture of two diastereoisomeric pairs and this complicates its metabolism, each biotransfonnation affording a mixture of isomers. Metabolism has been studied under environmental conditions and in plants and mammals. Degradation in soil and sediments is slow and only small quantities of products (other than CO₂ and bound residues) are produced. Most information is available for mammals in which metabolism occurs mainly by oxidative routes followed by conjugation. The information presented below is derived from the UK MAFF Pesticide Safety Directorate (PSD, 1994).

Degradation

The hydrolytic stability of [¹⁴C]bitertanowl as measured at pH 4, 7 and 9 over 30 days at 25 and 40 °C. No decomposition was observed and the DT₅₀ was estimated at >1 year at 25 °C.
Aqueous solutions of [¹⁴C-triazole]-and [¹⁴C-biphenyl]-bitertanol were irradiated for 48 and 72 hours, respectively, using a mercury arc lamp under conditions somewhat exceeding natural sunlight. Calculated DT₅₀ values were 38-52 hours and an estimated environmental DT₅₀ was considered to be 11 days. 4-Hydroxybiphenyl (4) and 1,2,4-triazole (5) were identified as major photolysis products accounting for 12% and 53% of the radioactivity, respectively. These are shown in Scheme 1. At least six minor products were detected but these were not identified.
Very little degradation occurred under soil surface photolysis conditions simulating natural sunlight. No discrete products were detected. Bound residue increased to only 5% of the total over 35 days.

References

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] P. HILDEBRAND. Resistance of Venturia inaequalis to bitertanol and other demethylation-inhibiting fungicides[J]. Canadian Journal of Plant Pathology-revue Canadienne De Phytopathologie, 1988, 20 1: 311-316. DOI: 10.1080/07060668809501704
[3] XUAN LV . Effects of triazole fungicides on androgenic disruption and CYP3A4 enzyme activity[J]. Environmental Pollution, 2017, 222: Pages 504-512. DOI: 10.1016/j.envpol.2016.11.051
[4] ANGELA R. ALLEN Robert C M. Bitertanol, A triazole fungicide, increases operant responding but not motor activity[J]. Neurotoxicology and teratology, 1993, 15 4: Pages 237-242. DOI: 10.1016/0892-0362(93)90004-8

Bitertanol synthesis

Synthesis of Bitertanol from Aluminium isopropoxide and 1-([1,1'-biphenyl]-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

Bitertanol Preparation Products And Raw materials

Raw materials

Methanol solution Hydrazinium hydroxide solution 1,2,4-Triazole Biphenyl Pinacolone

Sodium borohydride Sulfuryl chloride 1-([1,1'-biphenyl]-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one Aluminium isopropoxide

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Preparation Products

Bitertanol Suppliers

Global( 140)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5235	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21590	55
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30227	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24597	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	12272	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8618662433356	3899766280@qq.com	China	26362	58
Changzhou AniKare Pharmatech Co., Ltd.	+86-0519-8359-8696 +8618018249389	sales@anikare.com	China	9962	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Tianfu Chemical Co.,Ltd.	55
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HANGZHOU LEAP CHEM CO., LTD.	58
ZHEJIANG JIUZHOU CHEM CO., LTD	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	58
Changzhou AniKare Pharmatech Co., Ltd.	58

View Lastest Price from Bitertanol manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-22	Bitertanol 55179-31-2	US $30.00-64.00 / mg		99.88%	10g	TargetMol Chemicals Inc.
	2025-05-26	Bitertanol 55179-31-2	US $10.70 / KG	10KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD

Bitertanol
55179-31-2
US $30.00-64.00 / mg
99.88%
TargetMol Chemicals Inc.

Bitertanol
55179-31-2
US $10.70 / KG
99%
Hebei Chuanghai Biotechnology Co,.LTD

Bitertanol Spectrum

Bitertanol(55179-31-2)¹HNMR

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1-(4-phenylphenoxy)-1-(1,2,4-triazole-1)-3,3-dimethylbutan-2-ol 1h-1,2,4-triazole-1-ethanol,beta-((1,1’-biphenyl)-4-yloxy)-alpha-(1,1-dimethyl baycor25wp baymat-spray 3,3-DIMETHYL-1-(4-PHENYLPHENOXY)-1-(1,2,4-TRIAZOL-1-YL)BUTAN-2-OL 1-[（1，1'-biphenyl)-4-yloxyl]-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol 1RS,2RS)-1-(biphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazole-l-yl)butan-2-ol beta-([1,1'-biphenyl]-4-yloxy)-alpha-tert-butyl-1H-1,2,4-triazol-1-ethanol b-([1,1'-Biphenyl]-4-yloxy)-a-tert-butyl-1H-1,2,4-triazol-1-ethanol 1-(4-Biphenylyloxy)-3,3-dimethyl-1-(1H-1,2,4-triazole-1-yl)-2-butanol 1-(Biphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol Baycoral Biloxuron ALL-RAC-1-(BIPHENYL-4-YLOXY)-3,3-DIMETHYL-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL Bitertanol Standard Bay KWG 0599 (Bayer) Baycor(Bayer) BITERTANOL MIXTURE OF DIASTEREOMERS,PEST BAYCOR, 100MG, NEAT SS-([1,1'-BIPHENYL]-4-YLOXY)-A-(1,1-DIMETHYLETHYL)-1H-1,2,4-TRIAZOLE-1-ETHANOL bitertanol (bsi,iso) (1RS,2RS (1RS,2RS:1RS,2RS)-1-(BIPHENYL-4-YLOXY)-3,3-DIMETHYL-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL BITERTANOL;BAYCOR;BILOXAZOL;KWG 0599 beta-((1,1’-biphenyl)-4-yloxy)-alpha-(1,1-dimethylethyl)-1h-1,2,4-triazole-1 biloxazol kwg0599 BITERTANOL BETA([1,1'BIPHENYL]-4-YLOXY)-I-(1,1-DIMETHYL-ETHYL)R-1H-1,2,4-TRIAZOLE-1-ETHANOL BAYCOR (TM) BAYCOR BAYMAT(R) BAY KWG 0599 B-([1,1'-BIPHENYL]-4-YLOXY)-A-(1,1-DIMETHYL-ETHYL)-1H-1,2,4-TRIAZOLE-1-ETHANOL SIBUTOL(R) SIBUTOL 1RS,2RS)-1-(Biphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol Baycor (TM) 100mg [55179-31-2] Baycor DC 300 β-([1,1'-Biphenyl]-4-yloxy)-α-(1,1-diMethylethyl)-1H-1,2,4-triazole-1-ethanol 1-([1,1'-biphenyl]-4-yloxy)-3,3-diMethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol Bitertanol 1 Bitertanol @100 μg/mL in MeOH Bitertanol@1000 μg/mL in Acetone Bitertanol Solution 1H-1,2,4-Triazole-1-ethanol, β-([1,1'-biphenyl]-4-yloxy)-α-(1,1-dimethylethyl)- 55179-31-2 Bitertanol AI3-27699 Caswell No. 334B R 33986 Bitertanol Solution in Methanol Bitertanol in Acetone Bitertanol in Methanol Bitertanol 10.0 μg/ml Ethyl acetate Bitertanol 100 μg/ml Acetonitrile L10660000ALBitertanoL10μg/mLin Acetonitrile Bitertanol, 10 mM in DMSO Bitertanol 10 μg/mL in Acetonitrile