4-(P-IODOPHENYL)BUTYRIC ACID
- CAS No.
- 27913-58-2
- Chemical Name:
- 4-(P-IODOPHENYL)BUTYRIC ACID
- Synonyms
- 4-Iodobenzenebutanoic acid;4-(P-IODOPHENYL)BUTYRIC ACID;4-(p-Lodophenyl)butyric acid;Benzenebutanoic acid, 4-iodo-;4-(p-Iodophenyl)butyric acid >=98%;4-(p-Iodophenyl)butyric acid;BENZENE DERIVATIVE(4-(P-IODOPHENYL)BUTYRIC ACID);4-(4-Iodophenyl)butanoic acid , 4-(p-Iodophenyl)butyric acid
- CBNumber:
- CB8444901
- Molecular Formula:
- C10H11IO2
- Molecular Weight:
- 290.1
- MDL Number:
- MFCD00063353
- MOL File:
- 27913-58-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-(p-Iodophenyl)butyric acid ≥98% | I5634 | 5g | $484 |
| 4-(p-Iodophenyl)butyric acid | I717540 | 10g | $325 |
| 4-(p-Iodophenyl)butyric acid | 59202 | 1g | $610 |
| 4-(P-IODOPHENYL)BUTYRIC ACID 95.00% | HCH0067028 | 5G | $1041.76 |
| 4-(p-Iodophenyl)butyric acid | Y1471 | 25g | $1117 |
| More product size | |||
| Melting point | 89-89.5 °C |
|---|---|
| Boiling point | 351.0±17.0 °C(Predicted) |
| Density | 1.686±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | Solid |
| pka | 4.74±0.10(Predicted) |
| color | White to Pale Yellow |
| InChI | InChI=1S/C10H11IO2/c11-9-6-4-8(5-7-9)2-1-3-10(12)13/h4-7H,1-3H2,(H,12,13) |
| InChIKey | OGOMLUBUDYFIOG-UHFFFAOYSA-N |
| SMILES | C1(CCCC(O)=O)=CC=C(I)C=C1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| WGK Germany | 3 |
4-(P-IODOPHENYL)BUTYRIC ACID price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I5634 | 4-(p-Iodophenyl)butyric acid ≥98% | 27913-58-2 | 5g | $484 | 2025-07-31 | Buy |
| TRC | I717540 | 4-(p-Iodophenyl)butyric acid | 27913-58-2 | 10g | $325 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 59202 | 4-(p-Iodophenyl)butyric acid | 27913-58-2 | 1g | $610 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0067028 | 4-(P-IODOPHENYL)BUTYRIC ACID 95.00% | 27913-58-2 | 5G | $1041.76 | 2021-12-16 | Buy |
| AK Scientific | Y1471 | 4-(p-Iodophenyl)butyric acid | 27913-58-2 | 25g | $1117 | 2021-12-16 | Buy |
4-(P-IODOPHENYL)BUTYRIC ACID Chemical Properties,Uses,Production
Uses
4-(p-Iodophenyl)butyric Acid is a reactant involved in the synthesis of meta- and paracyclophanes containing unsaturated amino acids and intramolecular Friedel-Crafts reactions for synthesis of 1-tetralones.
Uses
Reactant involved in:• ;Synthesis of meta- and paracyclophanes containing unsaturated amino acids1• ;Intramolecular Friedel-Crafts reactions for synthesis of 1-tetralones2Involved in investigations of pharmacological activity pertaining to:• ;Apoptosis, proliferation, and histon deacetylase activity in human colorectal cancer cells3,4• ;Portable albumin binders for extending the half-life of contrast agents5
Uses
4-(p-Iodophenyl)butyric Acid is a reactant involved in the synthesis of meta- and paracyclophanes containing unsaturated amino acids and intramolecular Friedel-Crafts reactions for synthesis of 1-tetralones.
Synthesis
1821-12-1
27913-58-2
4-Phenylbutyric acid (20.0 g, 121.8 mmol) was added to a mixed solution of periodate (H5IO6, 5.56 g, 24.4 mmol), iodine (I2, 13.30 g, 52.4 mmol), 10 M sulfuric acid (H2SO4, 5.0 mL), water (36 mL), and acetic acid (166 mL), and the reaction was heated at 70 °C for 19 hours. Upon completion of the reaction, the reaction mixture was cooled and evaporated to dryness. The residue was dissolved in ethyl acetate (EtOAc, 300 mL), washed sequentially with aqueous sodium thiosulfate (Na2S2O3) (2×200 mL) and saturated saline (2×200 mL), dried with anhydrous sodium sulfate (Na2SO4), filtered, and then the solvent was evaporated to give the crude product as a yellow solid. The crude product was recrystallized by ethyl acetate/hexane mixed solvent at 0 °C to afford the target product 4-(p-iodophenyl)butanoic acid as a light yellow solid (15.0 g, 42% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ11.0 (broad single peak, 1H), 7.61 (double peaks, J = 8.4 Hz, 2H), 6.95 (double peaks, J = 8.0 Hz, 2H), 2.63 (triple peak, J = 7.6 Hz, 2H), 2.38 (triple peak, J = 7.6 Hz, 2H).
References
[1] Mendeleev Communications, 2015, vol. 25, # 2, p. 111 - 113
[2] European Journal of Organic Chemistry, 2015, vol. 2015, # 27, p. 5919 - 5924
[3] Patent: US2018/66298, 2018, A1. Location in patent: Paragraph 0172; 0173; 0174
[4] Journal of the American Chemical Society, 1943, vol. 65, p. 1273,1274
[5] Patent: US2348231, 1940,
4-(P-IODOPHENYL)BUTYRIC ACID Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8830 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8422 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Huida Pharmaceutical Technology (Shanghai) Co., Ltd. | +8613601750004 | lizhi@pharoschem.com | China | 439 | 58 |
| Zhengzhou Lingzhiyue Technology Co., Ltd | +86-0371-55074660 +8613523716970 | Lingzhiyue@aliyun.com | China | 3145 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
View Lastest Price from 4-(P-IODOPHENYL)BUTYRIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-23 | 4-(P-IODOPHENYL)BUTYRIC ACID
27913-58-2
|
US $0.00-0.00 / KG | 1KG | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | |
 |
2023-12-04 | 4-(P-IODOPHENYL)BUTYRIC ACID
27913-58-2
|
US $0.00-0.00 / kg | 0.10000000149011612kg | 98% | 100kg | Huida Pharmaceutical Technology (Shanghai) Co., Ltd. | |
 |
2019-07-06 | 4-(P-IODOPHENYL)BUTYRIC ACID
27913-58-2
|
US $1.00 / KG | 1KG | 95% | 500KG | Career Henan Chemical Co |
-
- 4-(P-IODOPHENYL)BUTYRIC ACID
27913-58-2
- US $0.00-0.00 / KG
- 98%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- 4-(P-IODOPHENYL)BUTYRIC ACID
27913-58-2
- US $0.00-0.00 / kg
- 98%
- Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
-
- 4-(P-IODOPHENYL)BUTYRIC ACID
27913-58-2
- US $1.00 / KG
- 95%
- Career Henan Chemical Co
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