2-FLUORO-4-METHYLPHENOL
- CAS No.
- 452-81-3
- Chemical Name:
- 2-FLUORO-4-METHYLPHENOL
- Synonyms
- 2-Fluoro-p-cresol;2-FLUORO-4-METHYLPHENOL;Phenol, 2-fluoro-4-methyl-;3-Fluoro-4-hydroxytoluene, 2-Fluoro-p-cresol
- CBNumber:
- CB8451882
- Molecular Formula:
- C7H7FO
- Molecular Weight:
- 126.13
- MDL Number:
- MFCD03094332
- MOL File:
- 452-81-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Fluoro-4-methylphenol | F597140 | 100mg | $45 |
| 2-Fluoro-4-methylphenol | F597140 | 500mg | $65 |
| 2-Fluoro-4-methylphenol | PC5944 | 25g | $103 |
| 2-Fluoro-4-methylphenol | PC5944 | 100g | $317 |
| 2-Fluoro-4-methylphenol | 2701-3-06 | 25g | $136 |
| More product size | |||
| Boiling point | 173.0±20.0 °C(Predicted) |
|---|---|
| Density | 1.164±0.06 g/cm3(Predicted) |
| refractive index | 1.513 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 9.01±0.18(Predicted) |
| form | liquid |
| color | Clear, colourless |
| InChI | InChI=1S/C7H7FO/c1-5-2-3-7(9)6(8)4-5/h2-4,9H,1H3 |
| InChIKey | WJKISRFVKIOBCQ-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=C(C)C=C1F |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227-H302-H312-H314-H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P309-P310 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 20/21/22-34-22 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RIDADR | 2922 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2908990000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-FLUORO-4-METHYLPHENOL price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | F597140 | 2-Fluoro-4-methylphenol | 452-81-3 | 100mg | $45 | 2021-12-16 | Buy |
| TRC | F597140 | 2-Fluoro-4-methylphenol | 452-81-3 | 500mg | $65 | 2021-12-16 | Buy |
| Apolloscientific | PC5944 | 2-Fluoro-4-methylphenol | 452-81-3 | 25g | $103 | 2021-12-16 | Buy |
| Apolloscientific | PC5944 | 2-Fluoro-4-methylphenol | 452-81-3 | 100g | $317 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2701-3-06 | 2-Fluoro-4-methylphenol | 452-81-3 | 25g | $136 | 2021-12-16 | Buy |
2-FLUORO-4-METHYLPHENOL Chemical Properties,Uses,Production
Synthesis
106-44-5
452-81-3
77249-33-3
GENERAL METHOD: To a solution of the substrate 4-methylphenol (1 mmol) in 10 mL of solvent (acetonitrile or methanol) was added Fluoride Reagent 1, 2 or 3 (1.1 mmol). The reaction mixture was stirred under reflux conditions for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was dissolved in 50 mL of dichloromethane and filtered to remove insoluble material. The filtrate was washed with 30 mL of water and the organic layer was dried with anhydrous sodium sulfate followed by evaporation of the solvent. The crude product was analyzed by 1H NMR and 19F NMR spectroscopy. The relative distribution and total yield of the fluorinated products were determined by 19F NMR using octafluoronaphthalene (OFN) as an internal standard. The identification of the products was accomplished by comparing their NMR spectral data with those reported in the literature, independently prepared samples, or their conversion to known compounds. In the presence of excess reagents, 2-fluoro-4-alkyl-substituted phenols or alkoxybenzenes (5, see Scheme 1) can be converted to 2,2-difluoro-4-alkyl-3,5-cyclohexadienones (unknown compounds 8b or 8c) or hydrolyzed to 2-fluoro-4-methylphenols (4aa). 4-fluoro-4-alkyl-2,5-cyclohexadienones (6a, 6b, and 6c) were determined by preparative thin layer chromatography (silica gel , dichloromethane/petroleum ether, 4:1) from the crude mixture and identified on the basis of their spectral data. Also, 4-fluoroalkoxybenzene derivatives could be identified by hydrolytic conversion to 4-fluorophenol or by comparison with independently prepared compounds.
References
[1] Journal of Fluorine Chemistry, 1981, vol. 17, p. 159 - 172
[2] European Journal of Organic Chemistry, 2017, vol. 2017, # 17, p. 2469 - 2474
[3] Journal of Fluorine Chemistry, 2013, vol. 156, p. 276 - 282
[4] Tetrahedron, 2006, vol. 62, # 18, p. 4474 - 4481
2-FLUORO-4-METHYLPHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3589 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 967 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
View Lastest Price from 2-FLUORO-4-METHYLPHENOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-12 | 2-FLUORO-4-METHYLPHENOL
452-81-3
|
US $40.00-20.00 / KG | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- 2-FLUORO-4-METHYLPHENOL
452-81-3
- US $40.00-20.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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