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ChemicalBook >> CAS DataBase List >>4-[(4-Methylpiperazin-1-yl)methyl]aniline

4-[(4-Methylpiperazin-1-yl)methyl]aniline

4-[(4-Methylpiperazin-1-yl)methyl]aniline Structure
4-[(4-Methylpiperazin-1-yl)methyl]aniline structure
CAS No.
70261-82-4
Chemical Name:
4-[(4-Methylpiperazin-1-yl)methyl]aniline
Synonyms
FN1501;AKOS BB-8955;1-methyl-4-(4-aminobenzyl)piperazine;1-(4-Aminobenzyl)-4-methylpiperazine;4-[(4-methyl-1-piperazinyl)methyl]aniline;4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-ANILINE;4-((4-methylpiperazin-1-yl)methyl)benzenamine;4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-PHENYLAMINE;4-(4-Methylpiperazin-1-ylmethyl)phenylamine95%;4-[(4-Methyl-1-piperazinyl)methyl]-benzenamine
CBNumber:
CB8464457
Molecular Formula:
C12H19N3
Molecular Weight:
205.3
MDL Number:
MFCD03725418
MOL File:
70261-82-4.mol
MSDS File:
SDS
Last updated:2025-08-08 17:45:00
Product description Number Pack Size Price
4-(4-Methylpiperazin-1-ylmethyl)phenylamine M327310 10g $100
4-(4-METHYLPIPERAZIN-1-YLMETHYL)PHENYLAMINE 95.00% COR0002706 2.5G $1227.82
4-(4-METHYLPIPERAZIN-1-YLMETHYL)PHENYLAMINE 95.00% COR0002706 5G $1548.26
4-(4-Methyl-piperazin-1-ylmethyl)-phenylamine 010950 500mg $25
4-(4-Methyl-piperazin-1-ylmethyl)-phenylamine 010950 1g $39
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4-[(4-Methylpiperazin-1-yl)methyl]aniline Properties

Melting point 97-99oC
Boiling point 331.2±27.0 °C(Predicted)
Density 1.085±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility Chloroform (Slightly), Methanol (Slightly)
pka 7.65±0.10(Predicted)
form Solid
color Yellow
FDA UNII 6MC966B505

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS02
Signal word  Warning
Hazard statements  H226
Precautionary statements  P501-P240-P210-P233-P243-P241-P242-P280-P370+P378-P303+P361+P353-P403+P235
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
HazardClass  IRRITANT
HS Code  2922390090

4-[(4-Methylpiperazin-1-yl)methyl]aniline price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M327310 4-(4-Methylpiperazin-1-ylmethyl)phenylamine 70261-82-4 10g $100 2021-12-16 Buy
American Custom Chemicals Corporation COR0002706 4-(4-METHYLPIPERAZIN-1-YLMETHYL)PHENYLAMINE 95.00% 70261-82-4 2.5G $1227.82 2021-12-16 Buy
American Custom Chemicals Corporation COR0002706 4-(4-METHYLPIPERAZIN-1-YLMETHYL)PHENYLAMINE 95.00% 70261-82-4 5G $1548.26 2021-12-16 Buy
Matrix Scientific 010950 4-(4-Methyl-piperazin-1-ylmethyl)-phenylamine 70261-82-4 500mg $25 2021-12-16 Buy
Matrix Scientific 010950 4-(4-Methyl-piperazin-1-ylmethyl)-phenylamine 70261-82-4 1g $39 2021-12-16 Buy
Product number Packaging Price Buy
M327310 10g $100 Buy
COR0002706 2.5G $1227.82 Buy
COR0002706 5G $1548.26 Buy
010950 500mg $25 Buy
010950 1g $39 Buy

4-[(4-Methylpiperazin-1-yl)methyl]aniline Chemical Properties,Uses,Production

Uses

4-(4-Methylpiperazin-1-ylmethyl)phenylamine is an intermediate used to prepare aminopyridopyrimidinones as tyrosine kinase inhibitors and anticancer agents. It is also used in the synthesis of piperazinyltrifluoromethylphenylquinolinylbenzonaphthyridinone derivatives with anticancer activities.

Synthesis

1-METHYL-4-(4-NITROBENZYL)PIPERAZINE

70261-81-3

4-[(4-Methylpiperazin-1-yl)methyl]aniline

70261-82-4

Step 2: Preparation of 4-(4-methylpiperazin-1-ylmethyl)aniline (F652-02) 1-Methyl-4-(4-nitrobenzyl)piperazine (F652-01, 4.67 g, 19.9 mmol), methanol (100 mL), zinc powder (6.5 g, 99.3 mmol), and ammonium chloride (4.3 g, 79.5 mmol) were added to a reaction vessel and heated and refluxed for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was filtered through diatomaceous earth. The filtrate was distilled under reduced pressure to remove the solvent to give a solid product. Diethyl ether was added to the solid and the insoluble material was removed by filtration. The filtrate was distilled to remove the solvent to give 4-(4-methylpiperazin-1-ylmethyl)aniline (F652-02, white solid, 3.16 g, 77% yield). LC/MS (Method 6): m/z (ESI, POS): 206 [M + H]+; retention time: 1.15 min. 1H-NMR (400 MHz, DMSO-d6) δ 2.12 (s, 3H), 2.29 (bs, 8H), 3.23 (s, 2H), 4.93 (s, 2H), 6.49 (d, J = 8.4 Hz, 2H), 6.89 (d, J = 8.4 Hz, 2H).

References

[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 2917 - 2929
[2] Patent: WO2004/46120, 2004, A2. Location in patent: Page 173
[3] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 15, p. 5738 - 5748
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 21, p. 8801 - 8815
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 4, p. 1499 - 1518

4-[(4-Methylpiperazin-1-yl)methyl]aniline Preparation Products And Raw materials

Raw materials

Ethanol Sodium chloride 1-Methylpiperazine Triethylamine Chloroform
Ferric chloride Hydrochloric acid Dichloromethane Iron 4-Nitrobenzyl chloride

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Preparation Products

4-[(4-Methylpiperazin-1-yl)methyl]aniline Suppliers

Global( 123)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10405 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29799 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81148696 +86-17392712697 1022@dideu.com China 3996 58
Richest Group Ltd 		18017061086 oled@richest-group.com CHINA 5600 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58
Nanjing Hengbei Chemicals Co., Ltd. 		+86-25-58393656 sales@hengbeichem.cn China 6854 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
Supplier Advantage
Shenzhen Nexconn Pharmatechs Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Richest Group Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Nanjing Hengbei Chemicals Co., Ltd. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58

View Lastest Price from 4-[(4-Methylpiperazin-1-yl)methyl]aniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-[(4-Methylpiperazin-1-yl)methyl]aniline pictures 2024-09-02 4-[(4-Methylpiperazin-1-yl)methyl]aniline
70261-82-4
 US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
4-[(4-Methylpiperazin-1-yl)methyl]aniline pictures 2024-08-30 4-[(4-Methylpiperazin-1-yl)methyl]aniline
70261-82-4
 US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
4-[(4-Methylpiperazin-1-yl)methyl]aniline pictures 2019-12-31 4-[(4-Methylpiperazin-1-yl)methyl]aniline
70261-82-4
 US $1.00 / KG 1KG 95-99% 1ton Career Henan Chemical Co

4-[(4-Methylpiperazin-1-yl)methyl]aniline Spectrum

4-[(4-Methylpiperazin-1-yl)methyl]aniline(70261-82-4)1HNMR

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4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-ANILINE 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-PHENYLAMINE AKOS BB-8955 4-(4-Methylpiperazin-1-ylmethyl)phenylamine95% 4-(4-METHYLPIPERAZIN-1-YLMETHYL)PHENYLAMINE 95% 4-((4-methylpiperazin-1-yl)methyl)benzenamine 1-(4-Aminobenzyl)-4-methylpiperazine Benzenamine, 4-[(4-methyl-1-piperazinyl)methyl]- 1-methyl-4-(4-aminobenzyl)piperazine FN1501 4-[(4-methyl-1-piperazinyl)methyl]aniline 4-[(4-Methyl-1-piperazinyl)methyl]-benzenamine 70261-82-4