CYLD ANTIBODY
- CAS No.
- Chemical Name:
- CYLD ANTIBODY
- Synonyms
- CYLD ANTIBODY
- CBNumber:
- CB84724775
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
CYLD ANTIBODY price More Price(2)
CYLD ANTIBODY Chemical Properties, Uses, Production
Source
Rabbit
Reactivity
Human;Monkey
Background
CYLD is a cytoplasmic deubiquitinating enzyme encoded by a tumor suppressor gene altered in individuals diagnosed with cylindromatosis, a genetic condition characterized by benign tumors of skin appendages. Functional CYLD deubiquitinase regulates inflammation and cell proliferation by down regulating NF-κB signaling through removal of ubiquitin chains from several NF-κB pathway proteins. CYLD is a negative regulator of proximal events in Wnt/β-catenin signaling and is a critical regulator of natural killer T cell development. The transcription factor Snail can inhibit CYLD expression, resulting in melanoma cell proliferation.
References
[1] Biggs, P.J. et al. (1995) Nat Genet 11, 441-3.
[2] Sun, S.C. (2010) Cell Death Differ 17, 25-34.
[3] Regamey, A. et al. (2003) J Exp Med 198, 1959-64.
[4] Glittenberg, M. and Ligoxygakis, P. (2007) Fly (Austin) 1, 330-2.
[5] Tauriello, D.V. et al. (2010) Mol Cell 37, 607-19.
[6] Lee, A.J. et al. (2010) EMBO J 29, 1600-12.
[7] Massoumi, R. et al. (2009) J Exp Med 206, 221-32.
CYLD ANTIBODY Preparation Products And Raw materials
Raw materials
Preparation Products
CYLD ANTIBODY Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 18007124176 19384116026 | 2706668885@qq.com | China | 4987 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 58 |
