KRN5
- CAS No.
- 1800465-47-7
- Chemical Name:
- KRN5
- Synonyms
- KRN5;KRN5,KRN-5;KRN5, 10 mM in DMSO;13-(2-Fluorobenzyl)-9,10-dimethoxy-5,6-dihydro-8H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-8-one;8H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizin-8-one, 13-[(2-fluorophenyl)methyl]-5,6-dihydro-9,10-dimethoxy-
- CBNumber:
- CB84796664
- Molecular Formula:
- C27H22FNO5
- Molecular Weight:
- 459.47
- MDL Number:
- MFCD31715427
- MOL File:
- 1800465-47-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| KRN5 98.58% | CS-0043390 | 5mg | $76 |
| KRN5 98.58% | CS-0043390 | 10mg | $119 |
| KRN5 98.58% | CS-0043390 | 25mg | $260 |
| KRN5 98.58% | CS-0043390 | 50mg | $336 |
| KRN5 98.58% | CS-0043390 | 100mg | $509 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
KRN5 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0043390 | KRN5 98.58% | 1800465-47-7 | 5mg | $76 | 2026-06-04 | Buy |
| ChemScene | CS-0043390 | KRN5 98.58% | 1800465-47-7 | 10mg | $119 | 2026-06-04 | Buy |
| ChemScene | CS-0043390 | KRN5 98.58% | 1800465-47-7 | 25mg | $260 | 2026-06-04 | Buy |
| ChemScene | CS-0043390 | KRN5 98.58% | 1800465-47-7 | 50mg | $336 | 2026-06-04 | Buy |
| ChemScene | CS-0043390 | KRN5 98.58% | 1800465-47-7 | 100mg | $509 | 2026-06-04 | Buy |
KRN5 Chemical Properties,Uses,Production
Uses
KRN5, a derivative of KRN2, is an oral active Nuclear factor of activated T cells 5 (NFAT5) suppressor, with an IC50 of 750 nM. KRN5 has potential to treat NFAT5-mediated Chronic Arthritis[1].
in vivo
Oral feeding of KRN5 (15 mg/kg and 60 mg/kg) every other day for 3 weeks from day 21 dose-dependently mitigates arthritis severity[1].
The concentration of serum anti-type II collagen IgG also significantly decreases in the sera of KRN5-treated mice. TNF-α and IL-6 production by LPS-stimulated splenocytes are significantly lower in KRN5-treated CIA mice than in vehicle-treated mice[1].
| Animal Model: | 8-week-old DBA/1Jmice immunized with bovine type II collagen[1]. |
| Dosage: | 15 mg/kg and 60 mg/kg. |
| Administration: | Orally on alternate days (every other day) for 3 weeks. |
| Result: | Dose-dependently mitigated arthritis severity. |
References
[1] Han EJ, et al. Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors. EBioMedicine. 2017 Apr;18:261-273. DOI:10.1016/j.ebiom.2017.03.039
KRN5 Preparation Products And Raw materials
Raw materials
Preparation Products
KRN5 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89686 | 60 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19103 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4334 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6753 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24958 | 58 |
