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ChemicalBook >> CAS DataBase List >>(S)-8-hydroxy-7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

(S)-8-hydroxy-7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

(S)-8-hydroxy-7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one Structure
(S)-8-hydroxy-7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one structure
CAS No.
945490-09-5
Chemical Name:
(S)-8-hydroxy-7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one
Synonyms
Pyrrolobenzodiazepine (PBD);*Chlorobutanol Impurity?2 (Chlorobutanol EP Impurity?B)(Acetone);(S)-8-hydroxy-7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one;(S)-8-Hydroxy-7-methoxy-2-methylene-1,2,3,11a-tetrahydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one
CBNumber:
CB84798365
Molecular Formula:
C14H14N2O3
Molecular Weight:
258.27256
MDL Number:
MFCD28716135
MOL File:
945490-09-5.mol
Last updated:2025-08-21 22:16:43
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(S)-8-hydroxy-7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one Properties

form Solid
color White to off-white

(S)-8-hydroxy-7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one Chemical Properties,Uses,Production

Uses

Tomaymycin DM, a DNA alkylator, is a derivative of Tomaymycin, it is a PBD dimer, which is attached to tumor targeting antibodies to create antibody-drug conjugates (ADCs).

IC 50

Pyrrolobenzodiazepines

References

[1] Dr. Julia Mantaj, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody–Drug Conjugates (ADCs). Angew Chem Int Ed Engl. 2017 Jan 9; 56(2): 462–488. DOI:10.1002/anie.201510610

(S)-8-hydroxy-7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-8-hydroxy-7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one Suppliers

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ChemExpress 		+86-19370970350 +86-021-58950125 info@chemexpress.com China 787 58
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BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
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ChemExpress 		58
TargetMol Chemicals Inc. 		58
BOC Sciences 65
BOC Sciences 65
Shanghai Haoyuan Chemexpress Co., Ltd. 58
ShangHai ChuanQian Chemcial Technique Centre 58
Bide Pharmatech Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58
guoyungurui 58
TargetMol Chemicals Inc. 58

View Lastest Price from (S)-8-hydroxy-7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tomaymycin DM pictures 2025-08-21 Tomaymycin DM
945490-09-5
 US $0.00-0.00 / mg 10g TargetMol Chemicals Inc.
  • Tomaymycin DM pictures
  • Tomaymycin DM
    945490-09-5
  • US $0.00-0.00 / mg
  • TargetMol Chemicals Inc.
(S)-8-hydroxy-7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]-pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one Pyrrolobenzodiazepine (PBD) *Chlorobutanol Impurity?2 (Chlorobutanol EP Impurity?B)(Acetone) (S)-8-Hydroxy-7-methoxy-2-methylene-1,2,3,11a-tetrahydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one 945490-09-5