N/aa
- CAS No.
- 1311136-84-1
- Chemical Name:
- N/aa
- Synonyms
- AUT1, 10 mM in DMSO;(R)-5-Ethyl-3-(6-(3-methoxy-4-methylphenoxy)pyridin-3-yl)imidazolidine-2,4-dione;(5R)-5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)pyridin-3-yl]imidazolidine-2,4-dione;(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione;2,4-Imidazolidinedione, 5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-, (5R)-;(R)-5-Ethyl-3-(6-(3-methoxy-4-methylphenoxy)pyridin-3-yl)imidazolidine-2,4-dione , AUT1;Kv3.1b,corticolimbic circuits,inhibit,AUT 1,AUT1,dysfunction,Potassium Channel,recombinant human Kv3 channels,human recombinant,KcsA,schizophrenia,Inhibitor,AUT-1,Kv3.2a
- CBNumber:
- CB84804783
- Molecular Formula:
- C18H19N3O4
- Molecular Weight:
- 341.36
- MDL Number:
- MFCD32062776
- MOL File:
- 1311136-84-1.mol
N/aa price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28599 | AUT1 | 1311136-84-1 | 10mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 28599 | AUT1 | 1311136-84-1 | 100mg | $341 | 2024-03-01 | Buy |
| Cayman Chemical | 28599 | AUT1 | 1311136-84-1 | 50mg | $193 | 2024-03-01 | Buy |
| TRC | E678890 | (5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione | 1311136-84-1 | 50mg | $185 | 2021-12-16 | Buy |
| TRC | E678890 | (5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione | 1311136-84-1 | 500mg | $1470 | 2021-12-16 | Buy |
N/aa Chemical Properties,Uses,Production
Description
AUT1 is a positive modulator of the voltage-gated potassium channel subtypes Kv3.1b, Kv3.2a, and Kv3.3 (EC50s = 4.7, 4.9, and 31.6 μM, respectively, in a patch-clamp assay). It is selective for Kv3.1b, Kv3.2a, and Kv3.3 over Kv1.5 and Kv7.1/minK channels but also inhibits the serotonin (5-HT) transporter, 5-HT3 receptor, and α1 subunit-containing nicotinic acetylcholine receptor (nAChR) in a panel of 26 ion channels, receptors, and transporters. AUT1 increases tetraethylammonium-induced decreases in the firing frequency and amplitude of action potentials in mouse somatosensory cortex slices when used at concentrations of 1 and 10 μM.
Uses
(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione, is a novel modulator of Kv3 potassium channels which biological studies have shown it regulates the firing of parvalbumin-positive cortical interneurons.
N/aa Preparation Products And Raw materials
Raw materials
Preparation Products
N/aa Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 12891 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 3969 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8829 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20342 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 19957148339; | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38838 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 |
