2-AMINO-3-FLUOROPHENOL
- CAS No.
- 53981-23-0
- Chemical Name:
- 2-AMINO-3-FLUOROPHENOL
- Synonyms
- 2-AMINO-3-FLUOROPHENOL;2-Fluoro-6-hydroxyaniline;Phenol, 2-aMino-3-fluoro-;6-Fluoro-2-hydroxyaniline;2-AMINO-3-FLUOROPHENOL ISO 9001：2015 REACH
- CBNumber:
- CB8480536
- Molecular Formula:
- C6H6FNO
- Molecular Weight:
- 127.12
- MDL Number:
- MFCD07368754
- MOL File:
- 53981-23-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Amino-3-fluorophenol | A609755 | 5g | $365 |
| 2-Amino-3-fluorophenol 98% | 041030 | 5g | $380 |
| 2-Amino-3-fluorophenol | FA44991 | 2g | $456 |
| 2-Amino-3-fluorophenol | FA44991 | 5G | $660 |
| 2-AMINO-3-FLUOROPHENOL 95.00% | HCH0011026 | 1G | $952.88 |
| Melting point | 126-127° |
|---|---|
| Boiling point | 221.9±25.0 °C(Predicted) |
| Density | 1.347±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| form | solid |
| pka | 8.76±0.10(Predicted) |
| color | Light yellow to brown |
| InChI | InChI=1S/C6H6FNO/c7-4-2-1-3-5(9)6(4)8/h1-3,9H,8H2 |
| InChIKey | QOZLOYKAFDTQNU-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=CC(F)=C1N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|---|---|
| Signal word | Warning |
| Hazard statements | H228 |
| Precautionary statements | P201-P202-P281-P308+P313-P370+P378r-P403-P501c |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22-37/38-41 |
| Safety Statements | 26-39 |
| RIDADR | 2512 |
| HazardClass | IRRITANT |
| PackingGroup | Ⅲ |
| HS Code | 2908990000 |
2-AMINO-3-FLUOROPHENOL price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A609755 | 2-Amino-3-fluorophenol | 53981-23-0 | 5g | $365 | 2021-12-16 | Buy |
| Matrix Scientific | 041030 | 2-Amino-3-fluorophenol 98% | 53981-23-0 | 5g | $380 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA44991 | 2-Amino-3-fluorophenol | 53981-23-0 | 2g | $456 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA44991 | 2-Amino-3-fluorophenol | 53981-23-0 | 5G | $660 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0011026 | 2-AMINO-3-FLUOROPHENOL 95.00% | 53981-23-0 | 1G | $952.88 | 2021-12-16 | Buy |
2-AMINO-3-FLUOROPHENOL Chemical Properties,Uses,Production
Uses
2-Amino-3-fluorophenol is a reagent that is used in the preparation of benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN) deficient cancers.
Synthesis
385-01-3
53981-23-0
Step 1. General procedure for the synthesis of 2-amino-3-fluorophenol from 3-fluoro-2-nitrophenol: Stannous chloride dihydrate (0.724 g, 3.18 mmol) was added to a solution of tetrahydrofuran (THF, 5.0 mL) of 3-fluoro-2-nitrophenol (0.100 g, 0.636 mmol, SynQuest), followed by water ( 5.0 mL). The reaction mixture was heated to 80 °C and maintained for 40 min. After the reaction was completed, it was cooled to room temperature and the reaction mixture was diluted with ethyl acetate and saturated sodium bicarbonate solution. The insoluble material was removed by filtration and the organic and aqueous layers were separated. The aqueous layer was extracted three times with ethyl acetate. The combined organic extracts were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product 2-amino-3-fluorophenol (65 mg, 80% yield), which could be used in the subsequent reaction without further purification.LCMS (M + H)+: 128.0.
References
[1] ChemMedChem, 2017, vol. 12, # 17, p. 1436 - 1448
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 2006, vol. 49, # 7, p. 623 - 634
[3] Patent: US5886044, 1999, A
[4] Patent: US5780483, 1998, A
[5] Patent: US6262113, 2001, B1
2-AMINO-3-FLUOROPHENOL Preparation Products And Raw materials
Raw materials
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Preparation Products
2-AMINO-3-FLUOROPHENOL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 10000 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9540 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
View Lastest Price from 2-AMINO-3-FLUOROPHENOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | 2-AMINO-3-FLUOROPHENOL
53981-23-0
|
US $1.00 / KG | 1KG | 98% | 200kgs | Career Henan Chemical Co |
-
- 2-AMINO-3-FLUOROPHENOL
53981-23-0
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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