Asp-2905)
- CAS No.
- 792184-90-8
- Chemical Name:
- Asp-2905)
- Synonyms
- Asp-2905);ASP 2905 (ASP2905;ASP2905, 10 mM in DMSO;N2-(4-fluorophenyl)-N?-phenyl-N?-(pyridin-2-yl)-1,3,5-triazine-2,4,6-triamine;N2-(4-Fluorophenyl)-N4-phenyl-N6-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine;1,3,5-Triazine-2,4,6-triamine, N2-(4-fluorophenyl)-N4-phenyl-N6-(2-pyrimidinylmethyl)-;Kv12.2,KcsA,Inhibitor,ASP2905,ASP 2905,cognitive,Kcnh3,CNS,Potassium Channel,inhibit,antipsychotic
- CBNumber:
- CB84844482
- Molecular Formula:
- C20H17FN8
- Molecular Weight:
- 388.4
- MDL Number:
- MFCD34179473
- MOL File:
- 792184-90-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Asp-2905) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 40780 | ASP2905 ≥95% | 792184-90-8 | 1mg | $64 | 2026-04-30 | Buy |
| Cayman Chemical | 40780 | ASP2905 ≥95% | 792184-90-8 | 5mg | $224 | 2026-04-30 | Buy |
| Cayman Chemical | 40780 | ASP2905 ≥95% | 792184-90-8 | 10mg | $383 | 2026-04-30 | Buy |
| Cayman Chemical | 40780 | ASP2905 ≥95% | 792184-90-8 | 25mg | $638 | 2026-04-30 | Buy |
| Biosynth | SGB18490 | ASP2905 | 792184-90-8 | 50mg | $828.5 | 2026-06-05 | Buy |
Asp-2905) Chemical Properties, Uses, Production
Description
ASP2905 hydrochloride is a potent and selective inhibitor of the potassium voltage-gated channel subfamily H member 3 (KCNH3).
Uses
ASP2905 is a potent and selective potassium channel Kv12.2 inhibitor encoded by the Kcnh3/BEC1 gene. ASP2905 can cross the blood-brain barrier and has antipsychotic activities[1][2].
in vivo
ASP2905 treatment inhibits hyperlocomotion induced by Phencyclidine. And significantly ameliorates Phencyclidine-induced prolongation of immobility time in mice subjected to the forced swimming test[2].
| Animal Model: | Male ddY mice (aged 4-5 weeks) injected with Phencyclidine hydrochloride (PCP)[2] |
| Dosage: | 0.01 mg/kg, 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg |
| Administration: | Oral administration; once |
| Result: | Inhibited hyperlocomotion induced by Phencyclidine. |
References
[1] Shinji Takahashi, et al. Neurochemical and neuropharmacological characterization of ASP2905, a novel potent selective inhibitor of the potassium channel KCNH3. Eur J Pharmacol. 2017 Sep 5;810:26-35. DOI:10.1016/j.ejphar.2017.05.045
[2] Shinji Takahashi, et al. ASP2905, a specific inhibitor of the potassium channel Kv12.2 encoded by the Kcnh3 gene, is psychoactive in mice. Behav Brain Res. 2020 Jan 27;378:112315. DOI:10.1016/j.bbr.2019.112315
[3] SHINJI TAKAHASHI. The KCNH3 inhibitor ASP2905 shows potential in the treatment of attention deficit/hyperactivity disorder.[J]. PLoS ONE, 2018: e0207750. DOI: 10.1371/journal.pone.0207750
Asp-2905) Preparation Products And Raw materials
Raw materials
Preparation Products
Asp-2905) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Taizhou Tongxin Bio-Tech Co., Ltd | 0523-86818997 18652728585 | sales@allyrise.com | China | 2998 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4865 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9770 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-13601744364 13601744364 | chemsharker@126.com | China | 1203 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4566 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
