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ChemicalBook >> CAS DataBase List >>AZ0108 (AZ 0108)

AZ0108 (AZ 0108)

AZ0108 (AZ 0108) Structure
AZ0108 (AZ 0108) structure
CAS No.
1825345-52-5
Chemical Name:
AZ0108 (AZ 0108)
Synonyms
AZ0108;AZ0108 (AZ 0108);1(2H)-Phthalazinone, 4-[[3-[[(6S)-3-(1,1-difluoroethyl)-5,6-dihydro-6-methyl-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]phenyl]difluoromethyl]-
CBNumber:
CB84844503
Molecular Formula:
C24H20F4N6O2
Molecular Weight:
500.45
MDL Number:
MOL File:
1825345-52-5.mol
MSDS File:
SDS
Last updated:2026-01-13 11:26:16
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AZ0108 (AZ 0108) Properties

Density 1.50±0.1 g/cm3(Predicted)
storage temp. -10 to -25°C
solubility DMSO: 2mg/mL, clear
pka 11.37±0.40(Predicted)
form powder
color white to beige
SMILES FC(C1=CC=CC(C(N2[C@@H](C)CN3C(C2)=NN=C3C(F)(F)C)=O)=C1)(F)C(C4=CC=CC=C45)=NNC5=O
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

AZ0108 (AZ 0108) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3872 AZ0108 ≥98% (HPLC) 1825345-52-5 5 mg $214 2026-04-30 Buy
Sigma-Aldrich SML3872 AZ0108 ≥98% (HPLC) 1825345-52-5 25 mg $856 2026-04-30 Buy
Sigma-Aldrich SML3872 AZ0108 ≥98% (HPLC) 1825345-52-5 1 unit $189.05 2025-07-31 Buy
ChemScene CS-0020495 AZ0108 1825345-52-5 5mg $602 2026-06-04 Buy
ChemScene CS-0020495 AZ0108 1825345-52-5 10mg $964 2026-06-04 Buy
Product number Packaging Price Buy
SML3872 5 mg $214 Buy
SML3872 25 mg $856 Buy
SML3872 1 unit $189.05 Buy
CS-0020495 5mg $602 Buy
CS-0020495 10mg $964 Buy

AZ0108 (AZ 0108) Chemical Properties, Uses, Production

Uses

AZ0108 is an inhibitor for poly ADP-ribose polymerase (PARP), which inhibits PARP1, PARP2, PARP3, PARP6, TNKS1, TNKS2, with IC50s of <0.03, <0.03, 2.8, 0.083, 3.2, >3 μM, respectively. AZ0108 prevents centrosome clustering with an EC50 of 0.053 μM, and exhibits cytotoxicity in cell OCI-LY-19 with GI50 of 0.017 μM. AZ0108 exhibits good in vivo pharmacokinetic characters in rat/mouse models[1].

Biological Activity

Inhibitor of Poly (ADP-ribose) polymerase PARP1, 2, and 6.

AZ0108 is an inhibitor of Poly (ADP-ribose) polymerase PARP1, 2, and 6 with approximately 100-fold selectivity against PARP3 and TNKS1. It was shown to block centrosome clustering in HeLa cells with an EC50 value of 53 nM and kill a DLBCL lymphoma cancer cell line with a GI50 value of 17 nM. AZ0108 induces replication stress in tumorigenic cells.

IC 50

PARP1: 0.03 μM (IC50); PARP2: 0.03 μM (IC50); PARP6: 0.083 μM (IC50); PARP3: 2.8 μM (IC50); TNKS1: 3.2 μM (IC50)

References

[1] Johannes JW, et al., Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5743-7. DOI:10.1016/j.bmcl.2015.10.079

AZ0108 (AZ 0108) Preparation Products And Raw materials

Raw materials

Preparation Products

AZ0108 (AZ 0108) Suppliers

Global Suppliers ( 3)
Supplier Tel Email Country ProdList Advantage
BOC Sciences +1-631-485-4226 inquiry@bocsci.com United States 19935 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
BOC Sciences 58
TargetMol Chemicals Inc. 58

1825345-52-5 (AZ0108 (AZ 0108)) Related Search:

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BMN 673

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AZ0108 (AZ 0108) AZ0108 1(2H)-Phthalazinone, 4-[[3-[[(6S)-3-(1,1-difluoroethyl)-5,6-dihydro-6-methyl-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]phenyl]difluoromethyl]- 1825345-52-5 C24H20F4N6O2