Olaratumab
- CAS No.
- 1024603-93-7
- Chemical Name:
- Olaratumab
- Synonyms
- IMC3G3;IMC 3G3;IMC-3G3;Lartruvo;LY3012207;LY-3012207;LY 3012207;Olaratumab;LY3012207|||IMC-3G3;Olaratumab (anti-PDGFRA)
- CBNumber:
- CB84845999
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| form | Liquid |
|---|---|
| color | Colorless to light yellow |
| FDA UNII | TT6HN20MVF |
| NCI Drug Dictionary | olaratumab |
| ATC code | L01XC27 |
Olaratumab Chemical Properties,Uses,Production
Uses
Olaratumab (IMC-3G3; LY3012207) is an anti-platelet-derived growth factor receptor alpha (PDGFRα) human monoclonal IgG1 antibody with antitumor activity[1].
Clinical Use
Monoclonal antibody:
Treatment of advanced soft tissue sarcoma in
combination with doxorubicin
in vivo
IMC-3G3 (i.p., 40 mg/kg, three times per week, 6 weeks) in SKOV3-ip1 tumor-bearing mice, compared with the control group, IMC-3G3 treatment alone had no obvious anti-tumor effect, while in HeyA8 tumor-bearing mice, IMC-3G3 monotherapy showed a significant anti-tumor effect compared with the control group, with a tumor reduction rate of 62%[1].
Drug interactions
Potentially hazardous interactions with other drugs
Live vaccines: avoid with olaratumab in combination
with doxorubicin.
Metabolism
Mainly degraded non-specifically by proteolytic enzymes.
References
[1] Koji Matsuo, et al. Platelet-derived growth factor receptor alpha (PDGFRα) targeting and relevant biomarkers in ovarian carcinoma. Gynecol Oncol. 2014 Jan;132(1):166-75. DOI:10.1016/j.ygyno.2013.10.027
Olaratumab Preparation Products And Raw materials
Raw materials
Preparation Products
Olaratumab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 7988 | 62 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1566 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10308 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24889 | 58 |
| Biolab Reagents | 18108604356 18108604356 | info@biolabreagent.com | China | 9868 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 6183 | 58 |
| Shanghai jerryxing Biomedical Technology Co., Ltd | 17721492509; 17721492509 | 643638326@qq.com | China | 4945 | 58 |
| Changsha Fuzhen Biotechnology Co.，LTD | 13823398779 13823398779 | 3062105966@qq.com | China | 3437 | 58 |