ChemicalBook >> CAS DataBase List >>Olaratumab

Olaratumab

CAS No.
1024603-93-7
Chemical Name:
Olaratumab
Synonyms
IMC3G3;IMC 3G3;IMC-3G3;Lartruvo;LY3012207;LY-3012207;LY 3012207;Olaratumab;LY3012207|||IMC-3G3;Olaratumab (anti-PDGFRA)
CBNumber:
CB84845999
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
Last updated:2025-04-18 09:52:55

Olaratumab Properties

form Liquid
color Colorless to light yellow
FDA UNII TT6HN20MVF
NCI Drug Dictionary olaratumab
ATC code L01XC27

Pharmacokinetic data

Excreted unchanged in urine Minimal
Volume of distribution 7.7 Litres
Biological half-life 11 days

Olaratumab Chemical Properties,Uses,Production

Uses

Olaratumab (IMC-3G3; LY3012207) is an anti-platelet-derived growth factor receptor alpha (PDGFRα) human monoclonal IgG1 antibody with antitumor activity[1].

Clinical Use

Monoclonal antibody:
Treatment of advanced soft tissue sarcoma in combination with doxorubicin

in vivo

IMC-3G3 (i.p., 40 mg/kg, three times per week, 6 weeks) in SKOV3-ip1 tumor-bearing mice, compared with the control group, IMC-3G3 treatment alone had no obvious anti-tumor effect, while in HeyA8 tumor-bearing mice, IMC-3G3 monotherapy showed a significant anti-tumor effect compared with the control group, with a tumor reduction rate of 62%[1].

Drug interactions

Potentially hazardous interactions with other drugs
Live vaccines: avoid with olaratumab in combination with doxorubicin.

Metabolism

Mainly degraded non-specifically by proteolytic enzymes.

References

[1] Koji Matsuo, et al. Platelet-derived growth factor receptor alpha (PDGFRα) targeting and relevant biomarkers in ovarian carcinoma. Gynecol Oncol. 2014 Jan;132(1):166-75. DOI:10.1016/j.ygyno.2013.10.027

Olaratumab Preparation Products And Raw materials

Raw materials

Preparation Products

Olaratumab Suppliers

Global( 18)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 7988 62
Guangzhou Hongyuan Chemical Co.,Ltd 15817493340 981810490@qq.com China 1566 58
Wuhan Chemstan Biotechnology Co., Ltd. 027-65317797 15926423062 422450190@qq.com China 10308 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24889 58
Biolab Reagents 18108604356 18108604356 info@biolabreagent.com China 9868 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 086-15871494362 13720134139 orders@jknbiochem.com China 6183 58
Shanghai jerryxing Biomedical Technology Co., Ltd 17721492509; 17721492509 643638326@qq.com China 4945 58
Changsha Fuzhen Biotechnology Co.,LTD 13823398779 13823398779 3062105966@qq.com China 3437 58
Olaratumab Research Grade Olaratumab(DHD16101) IMC 3G3 IMC3G3 IMC-3G3 Lartruvo LY 3012207 LY3012207 LY-3012207 LY3012207|||IMC-3G3 Research Grade Olaratumab Olaratumab (anti-PDGFRA) 1024603-93-7