GR 113808
- CAS No.
- 144625-51-4
- Chemical Name:
- GR 113808
- Synonyms
- GR 113808;GR113808, selective 5-HT4 antagonist;1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE;1-Methyl-1H-indole-3-carboxylicacid,[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyles;1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER;1H-Indole-3-carboxylic acid, 1-methyl-, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester;GR 113808;1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER;1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE;GR 113808
- CBNumber:
- CB8494704
- Molecular Formula:
- C19H27N3O4S
- Molecular Weight:
- 393.5
- MDL Number:
- MFCD00912901
- MOL File:
- 144625-51-4.mol
- MSDS File:
- SDS
| Boiling point | 572.3±53.0 °C(Predicted) |
|---|---|
| Density | 1.30±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 44 mg/mL, soluble |
| form | solid |
| pka | 11.22±0.40(Predicted) |
| color | white |
| FDA UNII | ZT350OYT3I |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
GR 113808 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G5918 | GR 113808 ≥98% (HPLC), solid | 144625-51-4 | 10mg | $200 | 2025-07-31 | Buy |
| Sigma-Aldrich | G5918 | GR 113808 ≥98% (HPLC), solid | 144625-51-4 | 50mg | $637 | 2025-07-31 | Buy |
| Sigma-Aldrich | 5.08120 | GR113808 - CAS 144625-51-4 - Calbiochem | 144625-51-4 | 10MG | $146 | 2022-05-15 | Buy |
| Cayman Chemical | 28733 | GR 113808 | 144625-51-4 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 28733 | GR 113808 | 144625-51-4 | 50mg | $638 | 2024-03-01 | Buy |
GR 113808 Chemical Properties,Uses,Production
Uses
GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to study its effects on the calcium (Ca2+) transients in rat ventricular cardiomyocytes. It has also been used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish.
Definition
ChEBI: An indolyl carboxylate ester obtained by formal condensation between the carboxy group of 1-methylindole-3-carboxylic acid with the hydroxy group of N-{2-[4-(hydroxymethyl)piperidin-1-yl]ethyl}methanesulfonamide.
Biological Activity
Potent, selective 5-HT 4 receptor antagonist (pK B = 9.43 in human colonic muscle, and K d = 0.15 nM for binding to cloned human 5-HT 4 receptors). Displays > 300-fold selectivity over 5-HT 1A , 5-HT 1B , 5-HT 2A , 5-HT 2C and 5-HT 3 receptors.
Biochem/physiol Actions
GR 113808 is a 5-HT4 serotonin receptor antagonist.
storage
Store at RT
GR 113808 Preparation Products And Raw materials
Raw materials
Preparation Products
GR 113808 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32431 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44814 | 58 |
| cjbscvictory | 13348960310 | 3003867561@qq.com | China | 10522 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29770 | 58 |
