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ChemicalBook >> CAS DataBase List >>Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl-

Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl-

Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl- Structure
Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl- structure
CAS No.
2068119-11-7
Chemical Name:
Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl-
Synonyms
S18-000003, 10 mM in DMSO;N-(2,4-Difluorophenyl)-2-(4-(2-(4-(ethylsulfonyl)phenyl)acetamido)-2-fluorophenyl)-2-methylpropanamide;Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl-;orphan,aberrations,ROR,acid,S18-000003,psoriasis,Inhibitor,RAR-related orphan receptor,retinoic,receptor-related,S18 000003,S-18-000003,RORγt,thymic,inhibit,S18000003
CBNumber:
CB85487404
Molecular Formula:
C26H25F3N2O4S
Molecular Weight:
518.55
MDL Number:
MFCD32067918
MOL File:
2068119-11-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:50:56
Product description Number Pack Size Price
S18-000003 THD11911 5mg $1067.3
S18-000003 THD11911 10mg $1477.8
S18-000003 THD11911 25mg $2570
S18-000003 THD11911 50mg $3426.5
S18-000003 THD11911 100mg $4997
Request For Quotation

Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl- Properties

Boiling point 746.1±60.0 °C(Predicted)
Density 1.358±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (192.85 mM; Need ultrasonic)
form Solid
pka 11.82±0.70(Predicted)
color White to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth THD11911 S18-000003 2068119-11-7 5mg $1067.3 2026-06-05 Buy
Biosynth THD11911 S18-000003 2068119-11-7 10mg $1477.8 2026-06-05 Buy
Biosynth THD11911 S18-000003 2068119-11-7 25mg $2570 2026-06-05 Buy
Biosynth THD11911 S18-000003 2068119-11-7 50mg $3426.5 2026-06-05 Buy
Biosynth THD11911 S18-000003 2068119-11-7 100mg $4997 2026-06-05 Buy
Product number Packaging Price Buy
THD11911 5mg $1067.3 Buy
THD11911 10mg $1477.8 Buy
THD11911 25mg $2570 Buy
THD11911 50mg $3426.5 Buy
THD11911 100mg $4997 Buy

Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl- Chemical Properties,Uses,Production

Uses

S18-000003 is a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of <30 nM towards human RORγt in competitive binding assays. S18-000003 shows selectivity for RORγt over other ROR family members (IC50>10 μM). S18-000003 can be used for the research of psoriasis with low risk of thymic aberrations[1][2].

in vivo

S18-000003 (30-100 mg/kg; p.o.) inhibits IL-17 production in the skin of IL-23-treated mice in a dose-dependent manner[1].
S18-000003 (0.1-8%; 100mL; topically administration once daily for 14 days) ameliorates psoriasis-like lesions in TPA-induced K14.Stat3C transgenic mice, and has little impact on the thymus[2].
S18-000003 (0.5 mg/kg; i.v.) exhibits the half-life (3.2 h), AUC (1930 ng h/mL), CLtot (4.33 mL/min/kg) and Vdss in rats[1].
S18-000003 (1 mg/kg; p.o.) exhibits the oral bioavailability (54.5%), Cmax (185 ng/mL), AUC (2110 ng h/mL) and Tmax (4 h) in rats[1].

IC 50

RORγt: <30 nM (IC50)

References

[1] Sasaki Y, et, al. Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3549-3553. DOI:10.1016/j.bmcl.2018.09.032
[2] Imura C, et, al. A novel RORγt inhibitor is a potential therapeutic agent for the topical treatment of psoriasis with low risk of thymic aberrations. J Dermatol Sci. 2019 Mar;93(3):176-185. DOI:10.1016/j.jdermsci.2019.03.002

Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl- Suppliers

Global( 33)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4849 55
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2826 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9804 58
Shanghai YuanYe Biotechnology Co., Ltd. 13636370518 shyysw007@163.com China 89686 60
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2980 58
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9625 58
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239 3193328036@qq.com China 29660 68
Zhaoqing Wanwei New Material Technology Co., Ltd. 0755-1328880-4488 13068786899 13288804488@163.com China 625 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Rechem science Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Zhaoqing Wanwei New Material Technology Co., Ltd. 58

View Lastest Price from Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
S18-000003 pictures 2026-04-21 S18-000003
2068119-11-7
 $52.00-198.00 99.81% 10g TargetMol Chemicals Inc.
  • S18-000003 pictures
  • S18-000003
    2068119-11-7
  • $52.00-198.00
  • 99.81%
  • TargetMol Chemicals Inc.

Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl- Spectrum

Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl-(2068119-11-7)1HNMR
Benzeneacetamide, N-(2,4-difluorophenyl)-4-[[2-[4-(ethylsulfonyl)phenyl]acetyl]amino]-2-fluoro-α,α-dimethyl- orphan,aberrations,ROR,acid,S18-000003,psoriasis,Inhibitor,RAR-related orphan receptor,retinoic,receptor-related,S18 000003,S-18-000003,RORγt,thymic,inhibit,S18000003 N-(2,4-Difluorophenyl)-2-(4-(2-(4-(ethylsulfonyl)phenyl)acetamido)-2-fluorophenyl)-2-methylpropanamide S18-000003, 10 mM in DMSO 2068119-11-7 C26H25F3N2O4S