GRK2 antibody
- CAS No.
- Chemical Name:
- GRK2 antibody
- Synonyms
- GRK2 antibody;Mouse Monoclonal GRK2 Antibody
- CBNumber:
- CB85632644
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
GRK2 antibody price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb621723 | GRK2 Antibody | 50μl | $400 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb621723 | GRK2 Antibody | 100μl | $540 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb570919 | GRK2 Antibody | 50μg | $140 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb570919 | GRK2 Antibody | 100μg | $220 | 2026-05-06 | Buy | |
| Biorbyt Ltd | orb570641 | GRK2 Antibody | 50μg | $140 | 2026-05-06 | Buy |
GRK2 antibody Chemical Properties,Uses,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat
Background
G protein-coupled receptor kinase 2, also known as beta-adrenergic receptor kinase 1, is a member of the GRK family, which phosphorylates the activated form of G protein-coupled receptors and initiates the desensitization process of GPCR. GRK2 kinase activity and cellular localization are tightly regulated by interactions with activated receptors, G-beta and G-gamma subunits, adaptor proteins, phospholipids, caveolin, and calmodulin, as well as by phosphorylation. Protein kinase C phosphorylation enhances GRK2 activity by promoting its membrane localization and by abolishing the inhibitory association of calmodulin. Protein kinase A phosphorylates GRK2 at Ser685, facilitating the association of GRK2 with a beta-adrenergic receptor. Erk inhibits GRK2 activity via phosphorylation at Ser670. Src phosphorylates GRK2 at multiple tyrosine residues, which activates GRK2 activity and promotes GRK2 degradation.
References
[1] Pitcher, J. A. et al. (1998) Annu. Rev. Biochem. 67, 653-692.
[2] Winstel, R. et al. (1996) Proc. Natl. Acad. Sci. USA 93, 2105-2109.
[3] Krasel, C. et al. (2001) J. Biol. Chem. 276, 1911-1915.
[4] Cong, M. et al. (2001) J. Biol. Chem. 276, 15192-15199.
[5] Pitcher, J. A. et al. (1999) J. Biol. Chem. 274, 34531-34534.
[6] Sarnago, S. et al. (1999) J. Biol. Chem. 274, 34411-34416.
[7] Penela, P. et al. (2001) EMBO J. 20, 5129-5138.
GRK2 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
GRK2 antibody Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| Hubei Ipodix Biotechnology Co.,Ltd. | 18007124176 19384116026 | 2706668885@qq.com | China | 4987 | 58 |
| Hubei Serenity BioSolutions Co., Ltd. | 027-19371278702 18008634902 | 19384116026@163.com | China | 3008 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Universal Biotech Co.,Ltd | 58 |
| Hubei Ipodix Biotechnology Co.,Ltd. | 58 |
| Hubei Serenity BioSolutions Co., Ltd. | 58 |
