HES1 (D6P2U) Rabbit mAb

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

HES1 is one of seven members of the HES family of basic helix-loop-helix transcription factors which function primarily to repress transcription of bHLH-dependent genes. HES1 is understood to play an important conserved role in maintaining pluripotency of embryonic and adult stem/progenitor cells via the transcriptional repression of genes that promote differentiation. HES1 is particularly well known as a repressive mediator of the canonical Notch signaling pathway. HES1 plays a key role in mediating Notch-dependent T cell lineage commitment, and has been reported to be an essential mediator of Notch-induced T cell acute lymphoblastic leukemia. HES1 is also reported to mediate Notch-induced repression of differentiation in a number of cancer cell types. A conditional deletion of HES1 from intestinal tumor cells in APC-mutant mice reduced tumor cell proliferation, while promoting differentiation toward epithelial lineages. Overexpression of HES1 in a human osteosarcoma cell line was shown to repress expression of the Notch antagonist Dtx1, leading to increased OS cell invasiveness. Other genes subject to transcriptional repression by HES1 include Neurogenin-2, Math1/Atoh1 and the NOTCH ligands DLL1 and Jagged1.

References

[1] Kageyama, R. et al. (2007) Development 134, 1243-51.
[2] Hatakeyama, J. et al. (2004) Development 131, 5539-50.
[3] Kobayashi, T. and Kageyama, R. (2010) Genes Cells 15, 689-98.
[4] Wendorff, A.A. et al. (2010) Immunity 33, 671-84.
[5] Espinosa, L. et al. (2010) Cancer Cell 18, 268-81.
[6] Ueo, T. et al. (2012) Development 139, 1071-82.
[7] Zhang, P. et al. (2010) Oncogene 29, 2916-26.
[8] Kageyama, R. et al. (2008) Dev Growth Differ 50 Suppl 1, S97-103.
[9] Kobayashi, T. et al. (2009) Genes Dev 23, 1870-5.

Raw materials

Preparation Products