NuMA Antibody

Source

Rabbit

Reactivity

Human;Monkey

Background

The nuclear mitotic apparatus protein is a coiled coil protein involved in the formation and maintenance of the mitotic spindle. NuMA plays a role in chromatin organization during interphase, which influences mammary epithelial differentiation. During apoptosis, carboxy-terminal cleavage of NuMA may amplify signaling in the cell death pathway. NuMA is phosphorylated at numerous sites, with phosphorylation at Ser395 occurring in an ATM/ATR-dependent manner in response to DNA damage.Phosphorylation at Thr2055 by CDK1 is required for spindle pole association of NuMA at the onset of mitosis. Dephosphorylation by PPP2CA leads to enhancement of NuMA at the cell cortex in anaphase and proper cell-cycle progression.

References

[1] Abad, P.C. et al. (2007) Mol Biol Cell 18, 348-61.
[2] Lin, H.H. et al. (2007) J Biomed Sci 14, 681-94.
[3] Stokes, M.P. et al. (2007) Proc Natl Acad Sci USA 104, 19855-60.
[4] Matsuoka, S. et al. (2007) Science 316, 1160-6.
[5] Kotak, S. et al. (2013) EMBO J 32, 2517-29.
[6] Seldin, L. et al. (2013) Mol Biol Cell 24, 3651-62.

Raw materials

Preparation Products