PARP (46D11) Rabbit mAb
- CAS No.
- Chemical Name:
- PARP (46D11) Rabbit mAb
- Synonyms
- PARP (46D11) Rabbit mAb
- CBNumber:
- CB85670253
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
PARP (46D11) Rabbit mAb Chemical Properties, Uses, Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
PARP, a 116 kDa nuclear poly polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA-binding domain from the carboxy-terminal catalytic domain. PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.
References
[1] Satoh, M.S. and Lindahl, T. (1992) Nature 356, 356-358.
[2] Lazebnik, Y. A. et al. (1994) Nature 371, 346-347.
[3] Cohen, G.M. (1997) Biochem. J. 326, 1-16.
[4] Nicholson, D. W. et al. (1995) Nature 376, 37-43.
[5] Tewari, M. et al. (1995) Cell 81, 801-809.
[6] Oliver, F.J. et al. (1998) J. Biol. Chem. 273, 33533-33539.
PARP (46D11) Rabbit mAb Preparation Products And Raw materials
Raw materials
Preparation Products
PARP (46D11) Rabbit mAb Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Universal Biotech Co.,Ltd | 58 |
