WIPI1 antibody
- CAS No.
- Chemical Name:
- WIPI1 antibody
- Synonyms
- WIPI1 antibody;Rabbit Monoclonal WIPI1 Antibody
- CBNumber:
- CB85705009
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
WIPI1 antibody Chemical Properties,Uses,Production
Source
Rabbit
Reactivity
Human
Background
Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. It is generally activated by conditions of nutrient deprivation but is also associated with a number of physiological processes including development, differentiation, neurodegeneration, infection, and cancer. The molecular machinery of autophagy was largely discovered in yeast and is directed by a number of autophagy-related genes.Vacuolar trafficking and autophagy are controlled by the class III type phosphoinositide 3-kinase Vps34, which generates phosphoinositide-3-phosphate. Atg18 and Atg21 are two related WD-repeat proteins that bind PtdIns3P via a conserved Phe-Arg-Arg-Gly motif. It has been shown that Atg18 binds to Atg2 and that this complex is directed to vacuolar membranes by its interaction with PtdIns3P. Human orthologs of Atg18 and Atg21 were identified as members of the WD-repeat protein Interacting with Phosphoinositides family. WIPI1 and WIPI2 have been shown to translocate from several vacuolar compartments to LC3-positive autophagosomes during autophagy; this translocation may be used as an autophagy marker.
References
[1] Reggiori, F. and Klionsky, D.J. (2002) Eukaryot Cell 1, 11-21.
[2] Codogno, P. and Meijer, A.J. (2005) Cell Death Differ 12 Suppl 2, 1509-18.
[3] Levine, B. and Yuan, J. (2005) J Clin Invest 115, 2679-88.
[4] Corvera, S. (2001) Traffic 2, 859-66.
[5] Yan, Y. and Backer, J.M. (2007) Biochem Soc Trans 35, 239-41.
[6] Krick, R. et al. (2006) FEBS Lett 580, 4632-8.
[7] Strømhaug, P.E. et al. (2004) Mol Biol Cell 15, 3553-66.
[8] Obara, K. et al. (2008) J Biol Chem 283, 23972-80.
[9] Jeffries, T.R. et al. (2004) Mol Biol Cell 15, 2652-63.
[10] Proikas-Cezanne, T. et al. (2007) FEBS Lett 581, 3396-404.
WIPI1 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
WIPI1 antibody Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CUSABIO TECHNOLOGY LLC | -- | cusabio@163.com | China | 6066 | 58 |
| GeneTex, Inc. | -- | international@genetex.com | China | 6092 | 58 |
| Enzo Biochem Inc | -- | Enzoname@qq.com | China | 6173 | 58 |
| Biosynth Ltd | -- | sales@biosynth.com | China | 6218 | 58 |
| Cell Signaling Technology Inc | -- | info@cellsignal.cn | China | 6725 | 58 |
| Abmart Inc | -- | market@ab-mart.com | China | 6917 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | -- | sales@biosynth.com | China | 6032 | 58 |
| Leading Biology Inc | -- | Info@leadingbiology.com | China | 6353 | 58 |
| Rockland Immunochemicals Inc | -- | antibodies-onlinename@qq.com | China | 6808 | 58 |
| Nanjing Jinzai Biotechnology Co., Ltd. | -- | CHINA | 2018 | 58 |
