JCN037
- CAS No.
- 2305154-31-6
- Chemical Name:
- JCN037
- Synonyms
- JCN037;JCN037, 10 mM in DMSO;N-(3-Bromo-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine;[1,4]Dioxino[2,3-g]quinazolin-4-amine, N-(3-bromo-2-fluorophenyl)-7,8-dihydro-;JCN037,Epidermal growth factor receptor,HER1,Inhibitor,JCN-037,JCN 037,inhibit,EGFR,JGK-037,ErbB-1,JGK037,JGK 037
- CBNumber:
- CB86187891
- Molecular Formula:
- C16H11BrFN3O2
- Molecular Weight:
- 376.18
- MDL Number:
- MFCD32693925
- MOL File:
- 2305154-31-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H315-H319-H361-H373 |
| Precautionary statements | P501-P260-P270-P202-P201-P264-P280-P302+P352-P308+P313-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P310+P330-P405 |
JCN037 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FSD15431 | JCN037 | 2305154-31-6 | 25mg | $1201 | 2026-06-04 | Buy |
| Biosynth | FSD15431 | JCN037 | 2305154-31-6 | 50mg | $1670.5 | 2026-06-04 | Buy |
| ChemScene | CS-0129398 | JCN037 99.09% | 2305154-31-6 | 5mg | $152 | 2026-06-04 | Buy |
| ChemScene | CS-0129398 | JCN037 99.09% | 2305154-31-6 | 10mg | $238 | 2026-06-04 | Buy |
| ChemScene | CS-0129398 | JCN037 99.09% | 2305154-31-6 | 50mg | $628 | 2026-06-04 | Buy |
JCN037 Chemical Properties, Uses, Production
Uses
JCN037 (JGK037) is non-covalent and BBB-penetrant EGFR tyrosine kinase inhibitor, with IC50 values of 2.49 nM, 3.95 nM, 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively[1].
in vivo
JCN037 (compound 5) exhibits low oral bioavailability due to a rapid hydroxylation of the fused 1,4-dioxane ring, suggesting first pass metabolism[1].
JCN037 (compound 5, 300 mg/kg, BID) treatment provides a significant survival benefit, whereby median survival increased by 47% from 37.5 days to 55 days with 5 treatment[1].
References
[1] Jonathan E. Tsang, et al. Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors. ACS Med. Chem. Lett. 2020. May 1.
JCN037 Preparation Products And Raw materials
Raw materials
Preparation Products
JCN037 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9711 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4999 | 58 |
| Hefei Mokai Pharmaceutical Technology Co., Ltd | 18130062233 | 690231469@qq.com | China | 8000 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
