YAP/TAZ Transcriptional Targets Antibody Sampler Kit
- CAS No.
- Chemical Name:
- YAP/TAZ Transcriptional Targets Antibody Sampler Kit
- Synonyms
- YAP/TAZ Transcriptional Targets Antibody Sampler Kit
- CBNumber:
- CB86280275
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
YAP/TAZ Transcriptional Targets Antibody Sampler Kit Chemical Properties, Uses, Production
Description
The YAP/TAZ Transcriptional Targets Antibody Sampler Kit provides an economical means of detecting proteins whose transcription is subject to regulation by the transcriptional co-activators YAP and/or TAZ. The kit provides enough antibody to perform two western blot experiments with each primary antibody.
Background
YAP and TAZ are transcriptional co-activators that play a central role in the Hippo Signaling pathway that regulates cell, tissue and organ growth. Under growth conditions, YAP and TAZ are translocated to the nucleus, where they interact with DNA-binding transcription factors to regulate the expression of genes that control fundamental aspects of cell function, such as proliferation and cell survival. A number of genes have been experimentally confirmed as targets of transcriptional regulation by YAP and TAZ. These include the extracellular matrix proteins CTGF, CYR61, and integrin β2, the inhibitor of apoptosis protein survivin, the mechano-sensitive nuclear envelope protein Lamin B2, and the oncogenic receptor tyrosine kinase Axl.
References
[1] Holden, J.K. and Cunningham, C.N. (2018) Cancers (Basel) 10, .
[2] Zhang, H. et al. (2009) J Biol Chem 284, 13355-62.
[3] Chan, S.W. et al. (2011) J Biol Chem 286, 7018-26.
[4] Chan, S.W. et al. (2011) Oncogene 30, 600-10.
[5] Zhang, W. et al. (2015) Cancer Res 75, 4450-7.
[6] Zanconato, F. et al. (2015) Nat Cell Biol 17, 1218-27.
[7] Cui, Z.L. et al. Int J Immunopathol Pharmacol 25, 989-1001.
YAP/TAZ Transcriptional Targets Antibody Sampler Kit Preparation Products And Raw materials
Raw materials
Preparation Products
YAP/TAZ Transcriptional Targets Antibody Sampler Kit Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Universal Biotech Co.,Ltd | 58 |
