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ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE

ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE structure

CAS No.: 776-53-4

Chemical Name:: ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE

Synonyms: 4-Amino-2-(methylthio)-;4-AMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CA...;hyl 4-aMino-2-(Methylthio)pyriMidine-5-carboxylate;Ethyl 4-amino-2-(methylthio)pyrimidin-5-carboxylate;thyl 4-aMino-2-(Methylthio)pyriMidine-5-carboxylate;Ethyl 4-aMino-2-(Methylthio)-5-pyriMidinecarboxylate;ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE;ethyl 4-amino-2-methylsulfanyl-pyrimidine-5-carboxylate;ETHYL-4-AMINO-2-METHYL MERCAPTO-PYRIMIDINE-4-CARBOXYLATE;ethyl 4-azanyl-2-methylsulfanyl-pyrimidine-5-carboxylate

CBNumber:: CB8664107

Molecular Formula:: C8H11N3O2S

Molecular Weight:: 213.26

MDL Number:: MFCD00090781

MOL File:: 776-53-4.mol

MSDS File:: SDS

Last updated:2026-01-13 11:26:23

Product description	Number	Pack Size	Price
4-Amino-2-(methylthio)-5-pyrimidinecarboxylicAcidEthylEster	A618240	1g	$1175
ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE 95.00%	CHM0077047	5G	$1379.44
4-Amino-2-(methylthio)-5-pyrimidinecarboxylicAcidEthylEster	19793	1g	$2620
ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE 95.00%	CHM0077047	1G	$794.34
4-Amino-2-(methylthio)-5-pyrimidinecarboxylicAcidEthylEster	19793	100mg	$890
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ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE Properties

Melting point	127-128 °C
Boiling point	370.3±22.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	solid
pka	2.46±0.10(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C8H11N3O2S/c1-3-13-7(12)5-4-10-8(14-2)11-6(5)9/h4H,3H2,1-2H3,(H2,9,10,11)
InChIKey	QINRQIZOBCQKAZ-UHFFFAOYSA-N
SMILES	C1(SC)=NC=C(C(OCC)=O)C(N)=N1
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09
Signal word	Warning
Hazard statements	H410
Precautionary statements	P501-P273-P391
Hazard Codes	Xi
Risk Statements	43
Safety Statements	36/37-24/25
WGK Germany	WGK 3
HS Code	29335990
Storage Class	11 - Combustible Solids
Hazard Classifications	Skin Sens. 1

ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A618240	4-Amino-2-(methylthio)-5-pyrimidinecarboxylicAcidEthylEster	776-53-4	1g	$1175	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0077047	ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE 95.00%	776-53-4	5G	$1379.44	2021-12-16	Buy
Medical Isotopes, Inc.	19793	4-Amino-2-(methylthio)-5-pyrimidinecarboxylicAcidEthylEster	776-53-4	1g	$2620	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0077047	ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE 95.00%	776-53-4	1G	$794.34	2021-12-16	Buy
Medical Isotopes, Inc.	19793	4-Amino-2-(methylthio)-5-pyrimidinecarboxylicAcidEthylEster	776-53-4	100mg	$890	2021-12-16	Buy

Product number	Packaging	Price	Buy
A618240	1g	$1175	Buy
CHM0077047	5G	$1379.44	Buy
19793	1g	$2620	Buy
CHM0077047	1G	$794.34	Buy
19793	100mg	$890	Buy

ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

Ethyl 4-amino-2-(methylthio)pyrimidine-5-carboxylate is used for preparation of pyrimidopyrimidines as protein kinase inhibitors.

Synthesis

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate

5909-24-0

ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE

776-53-4

Step 1. Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate (100 g, 0.43 mol), tetrahydrofuran (THF, 500 mL) and triethylamine (TEA, 186 mL, 1.29 mol) were added sequentially to a 2L three-neck flask. 28% aqueous ammonium hydroxide solution (400mL) was added in batches under stirring and the reaction temperature was controlled to be below 30°C. After 2 hrs of reaction, water (1000 mL) was added and THF was removed by vacuum distillation.The reaction mixture was filtered and the solid product was collected and dried under vacuum at 50 °C to afford ethyl 4-amino-2-(methylthio)pyrimidine-5-carboxylate as a white solid (90 g, 99% yield). The product was analyzed by LC/MS showing m/z = 213.9 [M+H]+; 1H-NMR (DMSO-d6, 400MHz) δ 8.57 (s, 1H), 8.03 (br, 1H), 7.65 (br, 1H), 4.27 (q, J = 7.5Hz, 2H), 2.46 (s, 3H), 1.29 (t, J = 7.2Hz , 3H).

References

[1] Patent: US2015/31674, 2015, A1. Location in patent: Paragraph 0319
[2] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 12, p. 1241 - 1246
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 11, p. 5520 - 5541
[4] Patent: WO2014/182829, 2014, A1. Location in patent: Page/Page column 42
[5] Patent: WO2015/120049, 2015, A1. Location in patent: Page/Page column 126; 127

ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Ethanol Diethyl ethoxymethylenemalonate Sodium Phosphorus oxitrichloride Dimethyl sulfide

Benzene 2-Methyl-2-thiopseudourea sulfate Acetic acid Ethyl (ethoxymethylene)cyanoacetate Thiourea

Dimethyl sulfate

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Preparation Products

ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE Suppliers

Global( 184)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29821	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5742	58
QINGDAO KAIENSI INTERNATIONAL TRADE CO.,LTD.	+86-0532-8699-9256 +8615254267723	kaley@cnfdevelop.com	China	1410	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
QINGDAO KAIENSI INTERNATIONAL TRADE CO.,LTD.	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58

View Lastest Price from ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE 776-53-4	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2025-04-04	Ethyl 4-amino-2-(methylthio)pyrimidine-5-carboxylate 776-53-4	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2019-07-06	4-AMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER 776-53-4	US $1.00 / kg	1kg	98%	100KG	Career Henan Chemical Co

ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE
776-53-4
US $1.10 / g
99.00%
Dideu Industries Group Limited

Ethyl 4-amino-2-(methylthio)pyrimidine-5-carboxylate
776-53-4
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

4-AMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
776-53-4
US $1.00 / kg
98%
Career Henan Chemical Co

ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE Spectrum

ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE(776-53-4)¹HNMR

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Ethyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE 4-AMINOPYRIMIDINE-5-CARBOXYLIC ACID 4-Aminopyrimidine {[4-AMINO-5-(ETHOXYCARBONYL)PYRIMIDIN-2-YL]THIO}ACETIC ACID

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4-AMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER ETHYL-4-AMINO-2-METHYL MERCAPTO-PYRIMIDINE-4-CARBOXYLATE ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE 4-AMINO-2-METHYLTHIO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER 4-Amino-2-(methylsulphanyl)pyrimidine-5-carboxylic acid ethyl ester ethyl 4-amino-2-methylsulfanyl-pyrimidine-5-carboxylate Ethyl 4-amino-2-(methylthio)pyrimidine-5-carboxylate ,97% Ethyl 4-amino-2-(methylthio)pyrimidin-5-carboxylate Ethyl 4-amino-2-(methylsulfanyl)-5-pyrimidinecarboxylate ethyl 4-azanyl-2-methylsulfanyl-pyrimidine-5-carboxylate Ethyl 4-aMino-2-(Methylthio)-5-pyriMidinecarboxylate 4-Amino-2-(methylthio)- 4-Amino-2-(methylthio)-5-pyrimidinecarboxylic Acid Ethyl Ester PyriMidin-5-carboxylic acid 4-aMino-2-(Methylthio)-, ethyl ester hyl 4-aMino-2-(Methylthio)pyriMidine-5-carboxylate thyl 4-aMino-2-(Methylthio)pyriMidine-5-carboxylate 4-AMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CA... 5-PyriMidinecarboxylic acid, 4-aMino-2-(Methylthio)-, ethyl ester JR-14015, Ethyl 4-amino-2-(methylthio)pyrimidine-5-carboxylate, 97% ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE ISO 9001：2015 REACH 5-Pyrimidinecarboxylic acid, 4-amino-2-(methylthio)-, ethyl ester (6CI, 7CI, 8CI, 9CI, ACI) 4-amino-2-(methylthio)-5-Pyrimidinecarboxylic acid ethyl ester (6CI 7CI 8CI 9CI ACI) ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE, 10 mM in DMSO 776-53-4 Pyrimidine series Amines Aromatics Heterocycles Sulfur & Selenium Compounds