1-Ethyl-2-pyrrolidone
- CAS No.
- 2687-91-4
- Chemical Name:
- 1-Ethyl-2-pyrrolidone
- Synonyms
- 1-ETHYL-2-PYRROLIDINONE;N-ETHYL-2-PYRROLIDONE;N-Ethylpyrrolidone;DDR1;N-Ethylpyrrolidinone;1-ETHYL-2-PYRROLIDONE;N-Ethyl-2-pyrrolidone (NEP);DDR;CAK;NEP crystal
- CBNumber:
- CB8666318
- Molecular Formula:
- C6H11NO
- Molecular Weight:
- 113.16
- MDL Number:
- MFCD00003199
- MOL File:
- 2687-91-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 87.5-88.5 °C |
|---|---|
| Boiling point | 97 °C/20 mmHg (lit.) |
| Density | 0.992 g/mL at 25 °C (lit.) |
| vapor pressure | 18Pa at 20℃ |
| refractive index |
n |
| Flash point | 169 °F |
| storage temp. | Sealed in dry,Room Temperature |
| pka | -0.41±0.20(Predicted) |
| form | Liquid |
| color | Clear |
| PH | 8-9 (100g/l, H2O, 20℃) |
| explosive limit | 1.3-7.7%(V) |
| biological source | rabbit |
| Water Solubility | 1000g/L at 23℃ |
| BRN | 107971 |
| Specific Activity | 4.25-5.75nmol/min·mg |
| Cosmetics Ingredients Functions | SOLVENT |
| InChI | 1S/C6H11NO/c1-2-7-5-3-4-6(7)8/h2-5H2,1H3 |
| InChIKey | ZFPGARUNNKGOBB-UHFFFAOYSA-N |
| SMILES | CCN1CCCC1=O |
| LogP | -0.2 at 20℃ |
| Surface tension | 36.5mN/m at 293.15K |
| REACH Annex XVII Substances List | 1-ethylpyrrolidin-2-one (NEP) (2687-91-4) |
| CAS DataBase Reference | 2687-91-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | H0229SX1CW |
| NIST Chemistry Reference | 1-Ethyl-2-pyrrolidinone(2687-91-4) |
| EPA Substance Registry System | 2-Pyrrolidinone, 1-ethyl- (2687-91-4) |
| UNSPSC Code | 12352203 |
| NACRES | NA.41 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H360D | |||||||||
| Precautionary statements | P202-P264-P280-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,T | |||||||||
| Risk Statements | 22-36-62-41-61 | |||||||||
| Safety Statements | 26-36-45-36/37/39-53 | |||||||||
| RIDADR | UN1993 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | UY5769250 | |||||||||
| Autoignition Temperature | 245°C (DIN 51794) | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| HS Code | 29337900 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Eye Dam. 1 Repr. 1B |
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| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
1-Ethyl-2-pyrrolidone price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB2900058 | Anti-DDR1 (AB1) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution | 2687-91-4 | 50μG | $777 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.42196 | 1-Ethyl-2-pyrrolidinone for synthesis | 2687-91-4 | 25 mL | $78.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 146358 | 1-Ethyl-2-pyrrolidone 98% | 2687-91-4 | 100g | $145 | 2026-04-30 | Buy |
| Sigma-Aldrich | 146358 | 1-Ethyl-2-pyrrolidone 98% | 2687-91-4 | 500g | $499 | 2026-04-30 | Buy |
| Sigma-Aldrich | SRP5020 | DDR1 (444-end), active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | 10 μg | $416 | 2025-07-31 | Buy |
1-Ethyl-2-pyrrolidone Chemical Properties, Uses, Production
Chemical Properties
N-Ethyl-2-pyrrolidone (NEP) is a colorless, clear liquid that serves as a low-volatility aprotic solvent classified as a reproductive toxicant. It is characterized by high solvency, low vapor pressure, and a low dielectric constant.
Uses
1-Ethyl-2-pyrrolidone was used to modify coir fiber (from Cocos nucifera) by photocuring.
Application
N-Ethyl-2-pyrrolidone is commonly used as a solvent. It has a low boiling point, which makes it suitable for use in low light and at constant pressure. It is also used as an intermediate in the preparation of polycarboxylic acid. It has been shown to be involved in both viscosity and hydrogen bonding.
Definition
ChEBI: 1-Ethyl-2-pyrrolidinone is a N-alkylpyrrolidine.
General Description
1-Ethyl-2-pyrrolidone is a transdermal absorption-enhancing compound and mechanism of its effect on multilammellar liposome of stratum corneum lipid has been studied.
Flammability and Explosibility
Non flammable
Biological Activity
CDK7 gene is a member of the cyclin-dependent protein kinase family th at is important regulators of cell cycle progression. CDK7 forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). CDK7 is an essential component of the transcription factor TFIIH th at is involved in transcription initiation and DNA repair. CDK7 is thought to serve as a direct link between the regulation of transcription and the cell cycle.
Side effects
Neurotoxins - Acute Solvent Syndrome
Occupational Hepatotoxin - Secondary Hepatotoxin: Cases of possible toxic effects in an occupational setting depending on human ingestion or experimental poisoning of animals.
Reproductive toxin - A chemical that is toxic to the reproductive system, including offspring defects and damage to male or female reproductive function. Reproductive toxicity includes developmental effects.
Safety Profile
Moderately toxic by ingestion. An eye irritant. Combustible. When heated to decomposition it emits toxic fumes of NOx.
Toxics Screening Level
The initial threshold screening level (ITSL) for 1-ethyl-2-pyrrolidone (CAS # 2687-91-4) is 4.9 μg/m3 based on an annual averaging time.
1-Ethyl-2-pyrrolidone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| NEM Materials Co.,Ltd. | +86-393-6101536 13725321862 | hjx@nem.com.cn | China | 12 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 551-65418679 15856988503;15837135945 | info@tnjchem.com | China | 1884 | 62 |
| HIGH HOPE INTERNATIONAL GROUP JIANGSU MEDICINES AND HEALTH PRODUCTS IMPORT AND EXPORT CORPORATION | 025-84691373 15312418043 | yxq@mehecojs.com | China | 117 | 58 |
| Puyang Kaisheng Chemical Co., Ltd. | 0393-6986680 13030328258 | kshg680@163.com | China | 22 | 58 |
| Zhongshan Dixin Chemical Co., Ltd | 19849939632; 19849939632 | 2470479589@qq.com | China | 1748 | 58 |
| Tangyuan Life Science (Shanghai) Co., Ltd | 400-618-1121 17316483629 | sales@townyuan.com | China | 2761 | 58 |
| Tianjin Zhongxin Chemtech Co., Ltd. | 022-66880623 | sales@tjzxchem.com | China | 612 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
Related articles
- Toxicity and biomonitoring of 1-ethyl-2-pyrrolidone
- 1-Ethyl-2-pyrrolidone, a polar aprotic solvent, is used in many applications. Herein its toxicity and biomonitoring will be re....
- Sep 16,2025
View Latest Price from 1-Ethyl-2-pyrrolidone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-19 | NEP
2687-91-4
|
$800.00 | 1G | 99.8% | 500KG | .GZ HONESTCHEM CO.,LTD | |
|
|
2026-09-19 | N-Ethyl-2-pyrrolidone | $800.00 | 1G | 99.8% | 500KG | .GZ HONESTCHEM CO.,LTD | |
|
|
2026-09-19 | ethyl-pyrrolidinone | $800.00 | 1G | 99.8% | 500KG | .GZ HONESTCHEM CO.,LTD |
-
- NEP
2687-91-4
- $800.00
- 99.8%
- .GZ HONESTCHEM CO.,LTD
-
- N-Ethyl-2-pyrrolidone
- $800.00
- 99.8%
- .GZ HONESTCHEM CO.,LTD
-
- ethyl-pyrrolidinone
- $800.00
- 99.8%
- .GZ HONESTCHEM CO.,LTD
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