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4-(4-Methylpiperazino)aniline

4-(4-Methylpiperazino)aniline structure

CAS No.: 16153-81-4

Chemical Name:: 4-(4-Methylpiperazino)aniline

Synonyms: 4-(4-METHYLPIPERAZIN-1-YL)ANILINE;1-(4-AMINOPHENYL)-4-METHYLPIPERAZINE;4-(4-methylpiperazin-1-yl)benzenamine;4-Methyl-1-(4-aminophenyl)piperazine;4-(4-MethyL;AKOS B021941;AKOS BB-8657;piperazino)aniL;ART-CHEM-BB B021941;OTAVA-BB BB7110920492

CBNumber:: CB8669359

Molecular Formula:: C11H17N3

Molecular Weight:: 191.27

MDL Number:: MFCD00172703

MOL File:: 16153-81-4.mol

MSDS File:: SDS

Last updated:2026-01-13 11:25:40

Product description	Number	Pack Size	Price
4-(4-Methyl-1-piperazinyl)aniline >98.0%(GC)	M2154	1g	$24
4-(4-Methyl-1-piperazinyl)aniline >98.0%(GC)	M2154	5g	$70
4-(4-Methylpiperazino)aniline	M325445	1g	$50
4-(4-Methylpiperazino)aniline 97%	033694	5g	$30
4-(4-Methylpiperazin-1-yl)aniline 99%	OR8114	5g	$32
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4-(4-Methylpiperazino)aniline Properties

Melting point	89 °C
Boiling point	180°C/5mmHg(lit.)
Density	1.092±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO (Sparingly), Methanol (Slightly)
form	Solid
pka	8.08±0.42(Predicted)
color	Very Dark Gray to Black
Sensitive	Air Sensitive
InChI	InChI=1S/C11H17N3/c1-13-6-8-14(9-7-13)11-4-2-10(12)3-5-11/h2-5H,6-9,12H2,1H3
InChIKey	MOZNZNKHRXRLLF-UHFFFAOYSA-N
SMILES	C1(N)=CC=C(N2CCN(C)CC2)C=C1
CAS DataBase Reference	16153-81-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H312-H314-H318-H332

Precautionary statements

P260h-P301+P330+P331-P303+P361+P353-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

Safety Statements

26-36/37/39-45

RIDADR

3259

Hazard Note

Corrosive

HazardClass

PackingGroup

III

HS Code

29349990

NFPA 704

	0
3		0

4-(4-Methylpiperazino)aniline price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M2154	4-(4-Methyl-1-piperazinyl)aniline >98.0%(GC)	16153-81-4	1g	$24	2025-07-31	Buy
TCI Chemical	M2154	4-(4-Methyl-1-piperazinyl)aniline >98.0%(GC)	16153-81-4	5g	$70	2025-07-31	Buy
TRC	M325445	4-(4-Methylpiperazino)aniline	16153-81-4	1g	$50	2021-12-16	Buy
Oakwood	033694	4-(4-Methylpiperazino)aniline 97%	16153-81-4	5g	$30	2021-12-16	Buy
Apolloscientific	OR8114	4-(4-Methylpiperazin-1-yl)aniline 99%	16153-81-4	5g	$32	2021-12-16	Buy

Product number	Packaging	Price	Buy
M2154	1g	$24	Buy
M2154	5g	$70	Buy
M325445	1g	$50	Buy
033694	5g	$30	Buy
OR8114	5g	$32	Buy

4-(4-Methylpiperazino)aniline Chemical Properties,Uses,Production

Chemical Properties

Purple solid

Uses

4-(4-Methylpiperazino)aniline is a reagent in the preparation of benzyloxypyridinone derivative which has c-Met kinase inhibitor properties.

Synthesis

16155-03-6

16153-81-4

GENERAL METHOD: 1-methyl-4-(4-nitrophenyl)piperazine (5.53 mmol) was dissolved in methanol (15 mL) and stirred under N2 atmosphere. Pd/C (2.78 mmol) was added to this solution. Subsequently, the reaction flask was placed in H2 atmosphere (balloon) for hydrogenation reaction overnight. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth plate and the filtrate was concentrated under vacuum. The crude product was purified by silica gel column chromatography (eluent: 5% MeOH/DCM containing 1% NH3) to afford the target compound 4-(4-methyl-1-piperazinyl)aniline (3a) as a brown solid in 87% yield.

References

[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 26, p. 8261 - 8269
[2] European Journal of Medicinal Chemistry, 2016, vol. 124, p. 896 - 905
[3] Patent: US6569878, 2003, B1
[4] Patent: EP1215208, 2002, A2. Location in patent: Example C(70)
[5] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 58; 59

4-(4-Methylpiperazino)aniline Preparation Products And Raw materials

Raw materials

4-Chloronitrobenzene N,N-Dimethylformamide Palladium hydroxide 1-Methylpiperazine Potassium carbonate

Chloroform Ethyl acetate Methanol Dimethyl sulfoxide 1-METHYL-4-(4-NITROPHENYL)PIPERAZINE

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Preparation Products

Olmutinib 4-Quinolinamine, N-[4-(4-methyl-1-piperazinyl)phenyl]-6-phenyl- 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- 6-Bromo-8-ethyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one 2-BROMO-4-(4-METHYLPIPERAZIN-1-YL)ANILINE

4-(4-Methylpiperazino)aniline Suppliers

Global( 346)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58

View Lastest Price from 4-(4-Methylpiperazino)aniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-25	4-(4-Methylpiperazino)aniline 16153-81-4	US $0.00 / gram	1gram	99%	10kg	Zhejiang J&C Biological Technology Co.,Limited
2025-04-04	4-(4-Methylpiperazino)aniline 16153-81-4	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2023-04-12	4-(4-Methylpiperazino)aniline 16153-81-4	US $15.00 / Kg/Bag	1Kg/Bag	99.7%	Weekly supply of 1000KG	Wuhan Dujiang Industrial Co., Ltd.

4-(4-Methylpiperazino)aniline
16153-81-4
US $0.00 / gram
99%
Zhejiang J&C Biological Technology Co.,Limited

4-(4-Methylpiperazino)aniline
16153-81-4
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

4-(4-Methylpiperazino)aniline
16153-81-4
US $15.00 / Kg/Bag
99.7%
Wuhan Dujiang Industrial Co., Ltd.

4-(4-Methylpiperazino)aniline Spectrum

4-(4-Methylpiperazino)aniline(16153-81-4)¹HNMR

16153-81-4(4-(4-Methylpiperazino)aniline)Related Search:

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3,3',5,5'-Tetramethylbenzidine dihydrochloride Dichloromethylphenylsilane N-Methylaniline 1-Methylpiperazine ANILINE BLACK

N,N-Dimethylaniline 3,4'-DIAMINODIPHENYLMETHANE p-Toluidine Tris(hydroxymethyl)aminomethane 4-(4-methylpiperazin-1-yl)aniline

Benzenamine, 4-(4-methyl-1-piperazinyl)-, monohydrochloride 1-METHYL-4-(4-NITROPHENYL)PIPERAZINE 2-(4-Methylpiperazin-1-yl)aniline

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OTAVA-BB BB7110920492 AKOS BB-8657 AKOS B021941 4-(4-METHYLPIPERAZINO)ANILINE 4-(4-METHYLPIPERAZINE)ANILINE 4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINE 4-(4-METHYLPIPERAZIN-1-YL)ANILINE 1-(4-AMINOPHENYL)-4-METHYLPIPERAZINE ART-CHEM-BB B021941 4-(4-Methyl-1-piperazinyl)aniline 4-Methyl-1-(4-aminophenyl)piperazine 1-(4-Aminophenyl)-4-methylpipe 4-Methyl-1-(4-Aminophenyl)Pipe Benzenamine, 4-(4-methyl-1-piperazinyl)- (9CI) 4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINE 98% 4-(4-MethyL piperazino)aniL 4-(4-methylpiperazin-1-yl)benzenamine 4-(4-Methyl-1-piperazino)aniline, 97% 4-(4-methylpiperazino)phenylamine 4-(N-Methylpiperazino)aniline 4-(4-Methylpiperazin-1-yl)aniline 99% 4-(4-Methyl-1-piperazinyl)phenylamine 4-(4-Methyl-1-piperazinyl)aniline,97% BenzenaMine, 4-(4-Methyl-1-piperazinyl)- 4-(4-Methyl-1-piperazinyl)aniline, >=98% 4-(4-Methylpiperazin-1-yl)aniline99% 4-(4-Methylpiperazin-1-yl)aniline DiHCl 4-(4-Methyl-piperazino)-anilin 4-(4-Methylpiperazino)aniline (ABA) 4-(4-Methyl-1-piperazinyl)-benzenamine 4-(4-Methyl-1-piperazinyl)aniline> 4-(4-AMINOPHENYL)-1-METHYLPIPERAZIN-1-IUM 16153-81-4 C11H18N3 C11H17N3 Phenyls & Phenyl-Het Piperazines Phenyls & Phenyl-Het Piperaizine API intermediates Piperazidine intermediates PIPERIDINE Amines and Anilines Heterocycles Amines