N-Boc-piperazine-2-carboxylic acid methyl ester
- CAS No.
- 129799-15-1
- Chemical Name:
- N-Boc-piperazine-2-carboxylic acid methyl ester
- Synonyms
- Piperazine-1,2-dicarb;Methyl 1-Boc-2-piperazinecarboxylate;METHYL 1-BOC-PIPERAZINE-2-CARBOXYLATE;N-Boc-piperazine-2-carboxylic acid methyl ester;1-Boc-piperazine-2-carboxylic acid methyl ester;1-N-BOC-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER;N-1-BOC-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER;1-Boc-2-Piperazinecarboxylic acid methyl ester;1-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER;1-tert-Butyl 2-Methyl piperazine-1,2-dicarboxylate
- CBNumber:
- CB8683676
- Molecular Formula:
- C11H20N2O4
- Molecular Weight:
- 244.29
- MDL Number:
- MFCD01861779
- MOL File:
- 129799-15-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-tert-Butyl2-methylpiperazine-1,2-dicarboxylate | B812450 | 500mg | $60 |
| 1-tert-Butyl2-methylpiperazine-1,2-dicarboxylate | B812450 | 1g | $75 |
| 1-tert-Butyl 2-methyl piperazine-1,2-dicarboxylate 95+% | 073556 | 1g | $60 |
| N-1-Boc-2-Piperazinecarboxylic acid methyl ester | FB44253 | 500mg | $65 |
| N-1-Boc-2-Piperazinecarboxylic acid methyl ester | FB44253 | 1g | $100 |
| More product size | |||
| Boiling point | 321.3±37.0 °C(Predicted) |
|---|---|
| Density | 1.118g/ml |
| storage temp. | 2-8°C(protect from light) |
| form | gel/ oil |
| pka | 7.25±0.40(Predicted) |
| color | Yellow |
| optical activity | -2.9800° (C=0.50 g/100ml, MEOH, 20°C, 589nm) |
| InChI | InChI=1S/C11H20N2O4/c1-11(2,3)17-10(15)13-6-5-12-7-8(13)9(14)16-4/h8,12H,5-7H2,1-4H3 |
| InChIKey | BRXKHIPPSTYCKO-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCNCC1C(OC)=O |
| CAS DataBase Reference | 129799-15-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-43-41-37/38 |
| Safety Statements | 26-36/37/39 |
| HS Code | 2933599590 |
N-Boc-piperazine-2-carboxylic acid methyl ester price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B812450 | 1-tert-Butyl2-methylpiperazine-1,2-dicarboxylate | 129799-15-1 | 500mg | $60 | 2021-12-16 | Buy |
| TRC | B812450 | 1-tert-Butyl2-methylpiperazine-1,2-dicarboxylate | 129799-15-1 | 1g | $75 | 2021-12-16 | Buy |
| Matrix Scientific | 073556 | 1-tert-Butyl 2-methyl piperazine-1,2-dicarboxylate 95+% | 129799-15-1 | 1g | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB44253 | N-1-Boc-2-Piperazinecarboxylic acid methyl ester | 129799-15-1 | 500mg | $65 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB44253 | N-1-Boc-2-Piperazinecarboxylic acid methyl ester | 129799-15-1 | 1g | $100 | 2021-12-16 | Buy |
N-Boc-piperazine-2-carboxylic acid methyl ester Chemical Properties,Uses,Production
Uses
1-tert-Butyl 2-methyl piperazine-1,2-dicarboxylate is a useful research chemical compound used in the preparation of piperazinylcarbonylaminomethylcarbonylpiperidines as melanocortin-4 receptor agonists.
Synthesis
129799-14-0
129799-15-1
The general procedure for the synthesis of methyl N-1-Boc-2-piperazinecarboxylate from 4-benzyl 1-tert-butyl 2-methylpiperazine-1,2,4-tricarboxylate is as follows: Example 53 - Preparation of Intermediate 18: The synthesis of Intermediate 18 followed General Procedure 14. To a solution of Intermediate 17 (1-benzyl stirred solution of 4-benzyl 1-methylpiperazine-1,2,4-tricarboxylic acid, 10 g, 26.5 mmol) in MeOH (100 mL) was added 10% Pd/C (30% w/w, 3.0 g). The mixture was placed in a steel vessel and stirred at room temperature under 50 psi hydrogen pressure for 5 hours. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the volatiles were concentrated under reduced pressure to afford 1-tert-butyl 2-methylpiperazine-1,2-dicarboxylate (Intermediate 18, 5.6 g, Yield: 88%) as a light yellow liquid.TLC conditions: 5% methanol-dichloromethane, Rf=0.3.
References
[1] Patent: WO2016/138532, 2016, A1. Location in patent: Paragraph 0288
[2] Patent: US2010/160323, 2010, A1. Location in patent: Page/Page column 47
[3] Patent: US4997836, 1991, A
[4] Patent: EP368670, 1990, A1
[5] Patent: US2004/116518, 2004, A1. Location in patent: Page 42
N-Boc-piperazine-2-carboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from N-Boc-piperazine-2-carboxylic acid methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | N-Boc-piperazine-2-carboxylic acid methyl ester
129799-15-1
|
US $1.00 / KG | 1KG | 99% | 10000Kgs | Career Henan Chemical Co |
-
- N-Boc-piperazine-2-carboxylic acid methyl ester
129799-15-1
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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