4-formyl-3-methoxybenzonitrile
- CAS No.
- 21962-45-8
- Chemical Name:
- 4-formyl-3-methoxybenzonitrile
- Synonyms
- 4-forMyl-3-Methoxybenzonitrile;4-Cyaon-2-methoxybenzaldehyde;Finerenone Impurity 111;2-Methoxy-4-cyanobenzaldehyde;4-CYANO-2-METHOXYBENZALDEHYDE;4-Cyan0-2-methoxybenzaldehyde;4-Formyl-3-methoxybenzonitril;3-Formyl-3-methoxybenzonitrile;Benzonitrile, 4-formyl-3-methoxy-;Para-tert-Butyl Benzene Sulfonamide
- CBNumber:
- CB8684633
- Molecular Formula:
- C9H7NO2
- Molecular Weight:
- 161.16
- MDL Number:
- MFCD07779491
- MOL File:
- 21962-45-8.mol
| Melting point | 109-111℃ |
|---|---|
| Boiling point | 318℃ |
| Density | 1.18 |
| vapor pressure | 0.003-2.3Pa at 20-80℃ |
| Flash point | 138℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| Appearance | Off-white to light yellow Solid |
| InChI | InChI=1S/C9H7NO2/c1-12-9-4-7(5-10)2-3-8(9)6-11/h2-4,6H,1H3 |
| InChIKey | ZXENVSJZOHXCKL-UHFFFAOYSA-N |
| SMILES | C(#N)C1=CC=C(C=O)C(OC)=C1 |
| LogP | 1.42 at 20℃ and pH7 |
4-formyl-3-methoxybenzonitrile price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C998488 | 4-Cyano-2-methoxybenzaldehyde | 21962-45-8 | 1g | $75 | 2021-12-16 | Buy |
| AK Scientific | J98031 | 4-Cyano-2-methoxybenzaldehyde | 21962-45-8 | 5g | $90 | 2021-12-16 | Buy |
| AK Scientific | X2725 | 4-Cyano-2-methoxybenzaldehyde | 21962-45-8 | 25g | $374 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0150549 | 4-CYANO-2-METHOXYBENZALDEHYDE 95.00% | 21962-45-8 | 5MG | $500.81 | 2021-12-16 | Buy |
| AHH | MT-07065 | 4-Cyaon-2-methoxybenzaldehyde 98% | 21962-45-8 | 25g | $518 | 2021-12-16 | Buy |
4-formyl-3-methoxybenzonitrile Chemical Properties,Uses,Production
Uses
4-formyl-3-methoxybenzonitrile is a Finerenone intermediate compound. Finerenone is a non-steroidal salicorticosteroid receptor antagonist used to reduce the risk of serious kidney and heart problems in patients with chronic kidney disease associated with type 2 diabetes.
Synthesis
79 g (370 mmol) of sodium metaperiodate are added in portions to a vigorously stirred solution of 48 g (185 mmol) of tert-butyl (2E)-3-(4-cyano-2-methoxyphenyl)acrylate, 207 mg (0.81 mmol) of osmium tetroxide and 1.4 g (6.14 mmol) of benzyltriethylammonium chloride in 750 ml of water/THF (2:1), keeping the reaction temperature below 30° C. The solution is stirred at RT for a further 1 h. Water (2000 ml) is added, and the mixture is filtered. The remaining solid is dissolved in ethyl acetate and washed with a saturated sodium chloride solution. The organic phase is dried over magnesium sulfate and concentrated. The residue is stirred with petroleum ether. 21.18 g (71% of theory) of 4-cyano-2-methoxybenzaldehyde (4-formyl-3-methoxybenzonitrile) is obtained as a white solid.
References
[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 10, p. 2468 - 2485
[2] Patent: EP1719767, 2006, A1. Location in patent: Page/Page column 24-26; 28; 33
4-formyl-3-methoxybenzonitrile Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chemsigma International Co., Ltd. | +86-2558742998 +86-19951791336 | info@chemsigma.com | China | 1749 | 58 |
| Suzhou Nordica Biopharma CO.,LTD | +86-18136148818 +86-18567353071 | 3537297702@qq.com | China | 299 | 58 |
| Zison Pharmaceutical (Shandong) Co., Ltd. | +86-0086-531-88259693 +86-18660188356 | tracy.li@zisonpharm.com | China | 78 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12303 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 | sales@sdperfect.com | China | 294 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1014 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20190 | 58 |
| Cangzhou Kangrui Pharma Tech Co. Ltd., | +86-18632776803 +86-13833998158 | cangzhoukangrui@126.com | China | 773 | 58 |
| Hebei Junhua Import and Export Co., LTD | +85259680964 | junhua1@hb-junhua.com | China | 933 | 58 |
View Lastest Price from 4-formyl-3-methoxybenzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-20 | 4-formyl-3-methoxybenzonitrile
21962-45-8
|
US $0.00-0.00 / kg | 1kg | 0.99 | 8000kg | Wuhan Biocar Pharmacy CO.,Ltd. | |
 |
2025-09-19 | 4-CYANO-2-METHOXYBENZALDEHYDE
21962-45-8
|
US $0.00 / kg | 1kg | 98% | 1000 | Hebei Junhua Import and Export Co., LTD | |
 |
2025-09-09 | 4-Cyano-2-methoxybenzaldehyde
21962-45-8
|
US $0.00-0.00 / kg | 1kg | 98% | 150kgs | Cangzhou Kangrui Pharma Tech Co. Ltd., |
-
- 4-formyl-3-methoxybenzonitrile
21962-45-8
- US $0.00-0.00 / kg
- 0.99
- Wuhan Biocar Pharmacy CO.,Ltd.
-
- 4-CYANO-2-METHOXYBENZALDEHYDE
21962-45-8
- US $0.00 / kg
- 98%
- Hebei Junhua Import and Export Co., LTD
-
- 4-Cyano-2-methoxybenzaldehyde
21962-45-8
- US $0.00-0.00 / kg
- 98%
- Cangzhou Kangrui Pharma Tech Co. Ltd.,
