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3-Chloropropionyl chloride

3-Chloropropionyl chloride structure

CAS No.: 625-36-5

Chemical Name:: 3-Chloropropionyl chloride

Synonyms: 3-Chloropropanoyl chloride;Chloropropionyl chloride;oropropionyL;3-Chloropropionyl ch;3-Chlorpropionylchlorid;-Chloropropanoylchloride;3-Chloropropinyl chloride;3-chloro-propanoylchlorid;3'ChloropropionylChloride;3-CHLOROPROPIONYL CHLORIDE

CBNumber:: CB8691211

Molecular Formula:: C3H4Cl2O

Molecular Weight:: 126.97

MDL Number:: MFCD00000747

MOL File:: 625-36-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:05:17

Product description	Number	Pack Size	Price
3-Chloropropionyl chloride 98%	C69128	100g	$150
3-Chloropropionyl chloride technical grade	147443	100ml	$61.9
3-Chloropropionyl Chloride	TRC-C380600-5G	5g	$65
3-Chloropropionyl Chloride	TRC-C380600-50G	50g	$151
3-Chloropropionyl Chloride	TRC-C380600-25G	25g	$109
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3-Chloropropionyl chloride Properties

Melting point	-32 °C
Boiling point	143-145 °C(lit.)
Density	1.33 g/mL at 25 °C(lit.)
vapor pressure	10.0 hPa
RTECS	UC3934000
refractive index	n20/D 1.457(lit.)
Flash point	146 °F
storage temp.	Flammables area
solubility	Chloroform, Ethyl Acetate
form	liquid
color	red-brown
PH	<7 (H2O)
explosive limit	8.8-20.2%(V)
Water Solubility	reacts
Sensitive	Moisture Sensitive
BRN	635814
Stability	Moisture Sensitive
InChI	1S/C3H4Cl2O/c4-2-1-3(5)6/h1-2H2
InChIKey	INUNLMUAPJVRME-UHFFFAOYSA-N
CAS DataBase Reference	625-36-5(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	24PO18998I
NIST Chemistry Reference	Propanoyl chloride, 3-chloro-(625-36-5)
EPA Substance Registry System	Propanoyl chloride, 3-chloro- (625-36-5)
UNSPSC Code	12352106

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06

Signal word

Danger

Hazard statements

H302-H314-H330

Precautionary statements

P260-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338

Hazard Codes

T+

Risk Statements

14-22-26-34-35-10

Safety Statements

23-26-36/37/39-45-38-16-8

RIDADR

UN 3390 6.1/PG 1

WGK Germany

Autoignition Temperature

460°C

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

HS Code

29159080

Storage Class

6.1A - Combustible, acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Acute Tox. 2 Inhalation
Acute Tox. 4 Oral
Skin Corr. 1B

REACH Registrations

Active

NFPA 704

	2
4		1

3-Chloropropionyl chloride price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C69128	3-Chloropropionyl chloride 98%	625-36-5	100g	$150	2026-04-30	Buy
Sigma-Aldrich	147443	3-Chloropropionyl chloride technical grade	625-36-5	100ml	$61.9	2026-04-30	Buy
TRC	TRC-C380600-5G	3-Chloropropionyl Chloride	625-36-5	5g	$65	2026-06-03	Buy
TRC	TRC-C380600-50G	3-Chloropropionyl Chloride	625-36-5	50g	$151	2026-06-03	Buy
TRC	TRC-C380600-25G	3-Chloropropionyl Chloride	625-36-5	25g	$109	2026-06-03	Buy

Product number	Packaging	Price	Buy
C69128	100g	$150	Buy
147443	100ml	$61.9	Buy
TRC-C380600-5G	5g	$65	Buy
TRC-C380600-50G	50g	$151	Buy
TRC-C380600-25G	25g	$109	Buy

3-Chloropropionyl chloride Chemical Properties,Uses,Production

Description

3-Chloropropionyl chloride is an important bifunctional reagent. It is capable of acylation and possesses a 2-chloro-ethyl fragment (CH2CH2Cl), which can be subjected to nucleophilic substitution and serves as a masked vinyl group. It can be used as a starting material in many reactions to construct a variety of (hetero)cyclic compounds.

Chemical Properties

Clear colorless to dark brown liquid. Soluble in ethanol, ether and chloroform. Slightly soluble in water.

Uses

3-Chloropropionyl chloride is a reagent used in the synthesis of Beclamide (B119400), which is a chlorinated benzylpropanamide used as an anticonvulsant drug. It is used in the treatment of tonic-clonic seizyres and has sedative properties.

Preparation

3-Chloropropionyl chloride (1) is commercially available and can be prepared from β-propiolactone (2) and thionyl chloride.1 Other standard methods available for the preparation of acyl chlorides can also be applied: the reaction of acrylic acid (3) or 3-chloropropionic acid (4) with thionyl chloride, phosphoryl chloride, phosgene, or phosphorus trichloride.
Synthesis of 3-Chloropropionyl chloride

Reactions

(1) The Friedel¨CCrafts acylation of tert-butylbenzene (5) with 3-chloropropionyl chloride (1) followed by cyclization provid- ed indanone 6, which was further transformed into urea derivative 7, a potent TRPV1 antagonist.
Reactions of 625-36-5_1
(2) A novel high-yielding one-pot microwave-assisted synthesis of condensed 5-substituted pyranoisoquinoline-1,6-diones 9 from 2-substituted isoquinoline-1,3-diones 8 and 3-chloropropionyl chloride (1) was reported.
Reactions of 625-36-5_2
(3) Acylation of 2-aminophenol (12) with 3-chloropropionyl chloride (1), followed by cyclization in the presence of polyphosphoric acid (PPA), gave benzoxazole 13, which was further reacted with 4-chlorophenyl-1-piperazine to yield the target benzo[d]oxazole analogue 14, a selective dopamine D4 receptor ligand.

Flammability and Explosibility

Non flammable

Synthesis

3-Chloropropionyl chloride is produced by reaction of acrylic acid with hydrogen chloride and phosgene in the presence of, for example,dimethylformamide as catalyst, or by reaction of propiolactone with thionyl chloride.

References

[1] Patent: WO2005/92842, 2005, A1. Location in patent: Page/Page column 18-19
[2] Angewandte Chemie, 1960, vol. 72, # 22, p. 836 - 845
[3] Patent: US2013/317248, 2013, A1. Location in patent: Paragraph 0061; 0062
[4] Patent: US2013/317252, 2013, A1. Location in patent: Paragraph 0091

3-Chloropropionyl chloride synthesis

Synthesis of 3-Chloropropionyl chloride from 3-Chloropropionic acid

3-Chloropropionyl chloride Preparation Products And Raw materials

Raw materials

Benzoyl peroxide Propionyl chloride 3-Chloropropionic acid 2-Chloropropionyl chloride Carbon tetrachloride

Sulfuryl chloride Thionyl chloride Acrylic acid

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Preparation Products

Tetrahydro-4-pyranol 5,6-DIHYDRO-4-METHOXY-2H-PYRAN Tetrahydro-4H-pyran-4-one Moricizine 2-Chloroethyl isocyanate

CO-1686 2-PYRAZOLINE 3-CHLORO-1-(2-METHYLPHENYL)-1-OXOPROPANE 2-(Diethylamino)-ethyl acrylate PYROQUILON

3-Chloro-1-(4-methoxyphenyl)propan-1-one 1 5-DICHLORO-3-PENTANONE 3-chloro-N-(2,4-dimethylphenyl)propanamide 3-CHLORO-N-CYCLOHEXYLPROPANAMIDE

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3-Chloropropionyl chloride Suppliers

Global( 485)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2163	58
Hubei Deli Pharmaceutical Technology Co., Ltd.	19237964946	dl@delipharm.com	China	97	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325	sales1@chuanghaibio.com	China	5216	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20111	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	13343047651	admin@zlchemi.com	China	3689	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	+1-5184799099;	lbaochemicals@gmail.com	China	670	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21531	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8618017249410	jack.li@time-chemicals.com	China	1796	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3004	60

Supplier	Advantage
Changzhou Ditong Chemical Co.,Ltd	58
Hubei Deli Pharmaceutical Technology Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60

Continuous Flow Production of 3-Chloropropionyl Chloride
3-Chloropropionyl chloride (versatile intermediate for drugs/polymers) is safely produced via continuous flow from acrylic aci....
Sep 22，2025

View Lastest Price from 3-Chloropropionyl chloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-14	3-Chloropropionyl chloride 625-36-5	$8.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-06-30	3-Chloropropionyl chloride 625-36-5		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-05-28	3-Chloropropionyl chloride 625-36-5	$9.10	1KG	99.%	10 ton	Hebei Chuanghai Biotechnology Co,.LTD

3-Chloropropionyl chloride
625-36-5
$8.00
99%
Henan Fengda Chemical Co., Ltd

3-Chloropropionyl chloride
625-36-5
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

3-Chloropropionyl chloride
625-36-5
$9.10
99.%
Hebei Chuanghai Biotechnology Co,.LTD

3-Chloropropionyl chloride Spectrum

3-Chloropropionyl chloride(625-36-5)MS 3-Chloropropionyl chloride(625-36-5)¹HNMR 3-Chloropropionyl chloride(625-36-5)¹³CNMR 3-Chloropropionyl chloride(625-36-5)IR1 3-Chloropropionyl chloride(625-36-5)Raman

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