Nigranoic acid
- CAS No.
- 39111-07-4
- Chemical Name:
- Nigranoic acid
- Synonyms
- Nigranoic acid;(3S,3aR,4aS,6aR,7R,9aS,9bS)-7-[(1R,4Z)-5-Carboxy-1-methyl-4-hexen-1-yl]decahydro-6a,9a-dimethyl-3-(1-methylethenyl)-1H-cyclopenta[a]cyclopropa[e]naphthalene-3a(4H)-propanoic acid;1H-Cyclopenta[a]cyclopropa[e]naphthalene-3a(4H)-propanoic acid, 7-[(1R,4Z)-5-carboxy-1-methyl-4-hexen-1-yl]decahydro-6a,9a-dimethyl-3-(1-methylethenyl)-, (3S,3aR,4aS,6aR,7R,9aS,9bS)-
- CBNumber:
- CB8693381
- Molecular Formula:
- C30H46O4
- Molecular Weight:
- 470.69
- MDL Number:
- MFCD28987443
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 128-130 °C |
|---|---|
| Boiling point | 603.0±28.0 °C(Predicted) |
| Density | 1.10±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Powder |
| pka | 4.78±0.10(Predicted) |
| color | Off-white to light yellow |
Nigranoic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 380941 | Nigranoic acid ≥98% | 39111-07-4 | 5mg | $792 | 2026-06-03 | Buy |
| Biosynth | FN65669 | Nigranoic acid | 39111-07-4 | 5mg | $272.1 | 2026-06-04 | Buy |
| Biosynth | FN65669 | Nigranoic acid | 39111-07-4 | 10mg | $453.7 | 2026-06-04 | Buy |
| Biosynth | FN65669 | Nigranoic acid | 39111-07-4 | 25mg | $907.25 | 2026-06-04 | Buy |
| Biosynth | FN65669 | Nigranoic acid | 39111-07-4 | 500mg | $10385 | 2026-06-04 | Buy |
Nigranoic acid Chemical Properties, Uses, Production
Uses
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model[1][2].
Definition
ChEBI: A tetracyclic triterpenoid that is 3,4-secocycloarta-4(28),24-(Z)-diene substituted by carboxy groups at positions 3 and 26. Isolated from Schisandra henryi and Schisandra propinqua, it exhibits cytotoxic and anti HIV activities.
in vivo
Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation[2].
Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points[2].
| Animal Model: | Sprague–Dawley rats (200-300 g), ischemia–reperfusion model[2] |
| Dosage: | 1 mg/kg |
| Administration: | Intragastric; 6 hours and 2 hours before brain ischemia |
| Result: | Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points. |
References
[1] Sun HD, et al. Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase. J Nat Prod. 1996 May;59(5):525-7. DOI:10.1021/np960149h
[2] Feng T, et al. Protective effects of nigranoic acid on cerebral ischemia-reperfusion injury and its mechanism involving apoptotic signaling pathway. Cell Biochem Biophys. 2015 Jan;71(1):345-51. DOI:10.1007/s12013-014-0204-1
Nigranoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Nigranoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
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| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
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| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
