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Primaxin monohydrate

Primaxin monohydrate Structure
Primaxin monohydrate structure
CAS No.
74431-23-5
Chemical Name:
Primaxin monohydrate
Synonyms
Imipenem Monohydrate≥ 96% (HPLC);CS-342;MK-0787;Imipenem;lmipemide;EOS-61603;Imipenem（b）;Imipenem hydrate;Tienam monohydrate;Imipenem n-Hydrate
CBNumber:
CB8695769
Molecular Formula:
C12H19N3O5S
Molecular Weight:
317.36
MDL Number:
MFCD00864955
MOL File:
74431-23-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-21 10:31:43
Product description Number Pack Size Price
Imipenem monohydrate ≥98% (HPLC) I0160 5mg $190
Imipenem monohydrate ≥98% (HPLC) I0160 25mg $752
Imipenem European Pharmacopoeia (EP) Reference Standard I0090000 70 mg $175
Imipenem European Pharmacopoeia (EP) Reference Standard I0090000 I0090000 $153
Imipenem (hydrate) ≥98% 16039 5mg $63
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Primaxin monohydrate Properties

Melting point 193-198°C
Boiling point 567℃
RTECS CL5446516
Flash point >110°(230°F)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility H2O: >5mg/mL
pka pKa 3.2/9.9(H2O,t = 25) (Uncertain)
form powder
color white to beige
optical activity [α]/D +73 to +84°, c =0.5 in water
Water Solubility Soluble in water at 5mg/ml
InChI InChI=1/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/s3
InChIKey GSOSVVULSKVSLQ-ONZDYIGBNA-N
SMILES C(C1=C(C[C@]2([H])[C@@]([H])([C@H](O)C)C(=O)N12)SCCNC=N)(=O)O.O |&1:4,6,8,r|
CAS DataBase Reference 74431-23-5(CAS DataBase Reference)
FDA UNII 71OTZ9ZE0A
NCI Dictionary of Cancer Terms imipenem
NCI Drug Dictionary imipenem
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
HS Code  2941906000
Storage Class 11 - Combustible Solids

Primaxin monohydrate price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I0160 Imipenem monohydrate ≥98% (HPLC) 74431-23-5 5mg $190 2026-04-30 Buy
Sigma-Aldrich I0160 Imipenem monohydrate ≥98% (HPLC) 74431-23-5 25mg $752 2026-04-30 Buy
Sigma-Aldrich I0090000 Imipenem European Pharmacopoeia (EP) Reference Standard 70 mg $175 2026-03-19 Buy
Sigma-Aldrich I0090000 Imipenem European Pharmacopoeia (EP) Reference Standard 74431-23-5 I0090000 $153 2024-03-01 Buy
Cayman Chemical 16039 Imipenem (hydrate) ≥98% 74431-23-5 5mg $63 2026-04-30 Buy
Product number Packaging Price Buy
I0160 5mg $190 Buy
I0160 25mg $752 Buy
I0090000 70 mg $175 Buy
I0090000 I0090000 $153 Buy
16039 5mg $63 Buy

Primaxin monohydrate Chemical Properties,Uses,Production

Chemical Properties

Imipenem (N-formimidoylthienamycin monohydrate) is a crystalline derivative of thienamycin, which is produced by Streptomyces cattleya. Its chemical name is (5 R,6S)-3-[[2-(formimidoylamino)ethyl]thio]-6-[( R)-1-hydroxyethyl ]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate. It is an off-white, nonhygroscopic crystalline compound with a molecular weight of 317.37. It is sparingly soluble in water and slightly soluble in methanol.

Discovery

Imipenem is an intravenous β-lactam antibiotic discovered by Merck scientists Burton Christensen, William Leanza, and Kenneth Wildonger in the mid-1970s. Imipenem was patented in 1975 and approved for medical use in 1985.
Imipenem has a broad spectrum of activity against aerobic and anaerobic, Gram-positive and Gram-negative bacteria. It is particularly important for its activity against Pseudomonas aeruginosa and the Enterococcus species. It is not active against MRSA, however.

Broad-spectrum antibiotic

Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.It is stable to many beta-lactamases. Similar compounds include meropenem, known for having greater activity against Gram negative bacteria, and the newer ertapenem which exhibits a longer half-life due to increased binding to plasma proteins.
Imipenem acts as an antimicrobial through the inhibition of cell wall synthesis of various gram-positive and gram-negative bacteria.This inhibition of cell wall synthesis in gram-negative bateria is attained by binding to penicillin-binding proteins (PBPs).

Chemical Properties

Off-White Solid

Uses

antiulcer

Uses

antidiabetic

Uses

Imipenem has a broad spectrum of antimicrobial action, which includes most clinically significant microorganisms: Gram-positive, Gram-negative, aerobic, and anaerobic. It is resistant with respect to most beta-lactamases of Gram-positive and Gram-negative bacteria. It is used for bacterial infections of the lower respiratory tract, infections of the urinary and sexual tracts, infections of bones, joints, skin, soft tissues, intraabdominal and gynecological infections, bacterial septicemia, and endocarditis.
Imipenem undergoes enzymatic inactivation in the kidneys. In order to avoid this problem, it is used in a 1:1 ratio in combination with cilastatin—the sodium salt of [R-[R,S-(Z)]]-7-[(2- amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)aminocarbonyl-2-heptenoic acid (32.1.3.6), which inhibits metabolisms of imipenem in the kidneys. This combination of two compounds is also used in medicine under the name primaxin.

Uses

An extremely broad-spectrum semi-synthetic antibiotic

Definition

ChEBI: Imipenem hydrate is a member of carbapenems. It contains an imipenem.

General Description

Chemical structure: -lactam

Biochem/physiol Actions

Imipenem is found effective against gram positive and negative aerobes and anaerobes. Imipenem is often combined with cilastatin, to inhibit its metabolism in kidney.

Synthesis

Imipenem, [5R-[5|á,6|á(R)]]-6-(1-hydroxyethyl)-3-[[2-[(iminomethyl)amino] ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-en-2-carboxylic acid (32.1.3.1), is the only carbapenem presently used in clinics. It is synthesized from thienamycin isolated from Streptomyces cattleya by reacting it with the methyl formimidate.

Synthesis_74431-23-5


Unlike penicillins and cephalosporins, which have a side aminoacyl group joined to the betalactam ring, imipenem has a |á-hydroxyethyl side chain. Significant resistance to hydrolysis by beta-lactamases is observed in this compound, evidently thanks to the trans-configuration of the side chain, while the side chain of penicillins and cephalosporins have a cis configuration.

Primaxin monohydrate Preparation Products And Raw materials

Raw materials

Silica glass 6-Aminopenicillanic acid INSTANT BUFFER S70, PH7.0 (ACC. TO SOERENSEN)(50PACKS) Trimethacrylate Benzyl ester
N,N-Dimethylformamide Sodium bisulfite water solution MERCURIC ACETATE Sodium nitrite Tetrahydrofuran
Ammonium chloride VINYLACETIC ACID Acetic acid Ammonium acetate Iodomethane

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Preparation Products

Primaxin monohydrate Suppliers

Global( 329)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649 sarah@tnjone.com China 1143 58
Apeloa production Co.,Limited 		+8619933239880 admin@apcl.com.cn China 861 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16513 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21590 55
Speranza Chemical Co., Ltd. 		+86-86-075521030354 +8618688942810 sophieliu@speranzachem.com China 923 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29819 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569262 +86-15003564040 1056@dideu.com China 3982 58
Supplier Advantage
Hebei Yanxi Chemical Co., Ltd. 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
Apeloa production Co.,Limited 		58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Speranza Chemical Co., Ltd. 		55
career henan chemical co 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58

Related articles

  • What is Imipenem?
  • Imipenem (N-formimidoylthienamycin monohydrate) is a crystalline derivative of thienamycin, which is produced by Streptomyces ....
  • Feb 19，2020

View Lastest Price from Primaxin monohydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Imipenem monohydrate pictures 2026-04-20 Imipenem monohydrate
74431-23-5
 US $53.00 / mg 99.17% 10g TargetMol Chemicals Inc.
Imipenem pictures 2026-04-17 Imipenem
74431-23-5
 US $2.00-6.00 / kg 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Imipenem pictures 2026-02-02 Imipenem
74431-23-5
 US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
  • Imipenem pictures
  • Imipenem
    74431-23-5
  • US $2.00-6.00 / kg
  • 99%
  • ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
  • Imipenem pictures
  • Imipenem
    74431-23-5
  • US $1.00-1.00 / KG
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd

Primaxin monohydrate Spectrum

Imipenem(74431-23-5)MSImipenem(74431-23-5)1HNMR

74431-23-5(Primaxin monohydrate)Related Search:

INTERMEDIANTE FOR IMIPENEM (5R,6S)-3-[(Diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester Ethylparaben Ethylbenzene 2-(METHYLSULFONYL)ETHANOL
Ethyl propionate Ethyl formate Ethyl acetate EC 2.6.1.2 Ethyl acrylate
Acetaminophen Sulfamic acid IMIPEMIDE IMIPENEM IMIPENEN N-FORMIMIDOYLTHIENAMYCIN TIENAMYCIN,Imipenem Glucosamine Ethanol
Imipenem Impurity 3 Imipenem Impurity 4 Imipenem EP Impurity B

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Imipenem Monohydrate≥ 96% (HPLC) Imipenem hydrate Imipenem Monohydrate (100 mg) Crude Grade of Imipenem (5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate, Primaxin monohydrate, Tienam monohydrate (6 R,7 R)-7-AMIMO-8-OXO-3-(1-PROPENYL)-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID Monohydrate (5R,6S)-3-((2-Formimidamidoethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate Primaxin monohydrate Tienam monohydrate Imipenem monohydrate, >=98% Imipenem Monohydrate, Antibiotic for Culture Media Use Only Imipenem n-Hydrate CS-342 (6 R,7 R)-7-AMIMO-8-OXO-3-(1-PROPENYL)-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID 5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-AMINO-8-OXO-3-(1-PROPENYL)-, (6R,7R)- (6 R ,7 R ) - 7-AMIMO-8-OXO-3-(1-PROPENYL)-5-THIA-1-AZABICYLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-[[2-[(iminomethyl) amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate Imipenem lmipemide MK-0787 (5R,6S)-3-((2-Formimidamidoethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.]hept-2-ene-2-carboxylic acid hydrate EOS-61603 IMIPEMIDE MONOHYDRATE [5R-[5α，6α(R^<*>^)]]-6-(1-hydroxyethyl)-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate N-Formimidoyl thienamycin monohydrate Imipenem USP/EP/BP Imipenem monohydrate (High purity) Imipenem 1-hydrate ?mipenem monohydrate Crude (6R,7R)-7-AMIMO-8-OXO-3-(1-PROPENYL)-5-THIA-1-azabicyclo[4.2... Imipenem MonohydrateQ: What is Imipenem Monohydrate Q: What is the CAS Number of Imipenem Monohydrate Q: What is the storage condition of Imipenem Monohydrate Imipenem crude(monohydrate non sterile) Imipenem Monohydrate (1337809) bacteria,Inhibitor,N-Formimidoyl thienamycin,P. aeruginosa,ntibiotic,MK0787,Imipenem monohydrate,MK 0787,MK-0787,infection,inhibit,Bacterial,Antibiotic,thienamycin Imipenem（b） lmipenem monohydrate Imipenem Monohydrate: (5R,6S)-6-[(R)-1-Hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]sulfanyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate 74431-23-5 C12H17N3O4SH2O ROXIT Intermediates & Fine Chemicals Pharmaceuticals