PREGNENOLONE SULFATE SODIUM SALT
- CAS No.
- 1852-38-6
- Chemical Name:
- PREGNENOLONE SULFATE SODIUM SALT
- Synonyms
- Pregnenolone 3-Sulfate;PREGNENOLONE SULFATE SODIUM;Pregnenolone-3-sulfate Sodium;SodiuM Pregnenolone-d4 Sulfate;5-Pregnen-3β-ol-20-one sulfate;Pregnenolone sulphate Na+ salt;Pregnenolone monosulfate sodium;PREGNENOLONE SULFATE SODIUM SALT;PREGNENOLONE SULPHATE, SODIUM SALT;Pregnenolone-3-sulfate SodiuM Salt
- CBNumber:
- CB8701970
- Molecular Formula:
- C21H32O5S.Na
- Molecular Weight:
- 419.53
- MDL Number:
- MFCD00056177
- MOL File:
- 1852-38-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Pregnenolone sulfate sodium salt | P162 | 25mg | $30.4 |
| Pregnenolone sulfate sodium salt | P162 | 100mg | $93.3 |
| Pregnenolone sulfate (sodium salt) ≥95% | 21004 | 50mg | $55 |
| Pregnenolone sulfate (sodium salt) ≥95% | 21004 | 100mg | $88 |
| Pregnenolone sulfate (sodium salt) ≥95% | 21004 | 250mg | $180 |
| Melting point | 192 °C(lit.) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | methanol and water: 1.93 mg/mL |
| form | A crystalline solid |
| color | White to off-white |
| InChIKey | ABFNHVDDMHKJKK-WRHGONFGSA-N |
| SMILES | [Na].[H][C@@]12CC=C3C[C@H](CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O)OS(O)(=O)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
PREGNENOLONE SULFATE SODIUM SALT price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P162 | Pregnenolone sulfate sodium salt | 1852-38-6 | 25mg | $30.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | P162 | Pregnenolone sulfate sodium salt | 1852-38-6 | 100mg | $93.3 | 2026-04-30 | Buy |
| Cayman Chemical | 21004 | Pregnenolone sulfate (sodium salt) ≥95% | 1852-38-6 | 50mg | $55 | 2026-04-30 | Buy |
| Cayman Chemical | 21004 | Pregnenolone sulfate (sodium salt) ≥95% | 1852-38-6 | 100mg | $88 | 2026-04-30 | Buy |
| Cayman Chemical | 21004 | Pregnenolone sulfate (sodium salt) ≥95% | 1852-38-6 | 250mg | $180 | 2026-04-30 | Buy |
PREGNENOLONE SULFATE SODIUM SALT Chemical Properties,Uses,Production
Description
Pregnenolone sulfate is a metabolite of the natural steroid hormone pregnenolone . Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).
Uses
Pregnenolone sulfate sodium salt has been used as sigma-1 receptor (σ1R) agonist. It has also been used in the stimulation and as a ligand for transient receptor potential melastatin-3 (TRPM3).
Uses
Pregnenolone Sulfate Sodium Salt, is a metabolite of Pregnenolone (P712200). It is also a neuroactive steroid, a potent and efficacious modulators of the GABAA receptor.
Biochem/physiol Actions
Pregnenolone sulfate is a neurosteroid and a neuromodulator. It is involved in the stimulation of N-methyl-D-aspartate receptor (NMDA), γ-Aminobutyric acid type A (GABAA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-kainate). It activates transient receptor potential melastatin (TRPM3) which is a calcium-permeable ion channel. It improves schizophrenia and behavioral anomalies by modulating NMDA mediated Ser/Thr kinase - glycogen synthase kinase 3 β (AKT/GSK3β) signaling pathway.
in vivo
Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule[1].
IC 50
CB1; Human Endogenous Metabolite
storage
Store at +4°C
References
[1] M SEDLáCEK. Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission.[J]. Physiological research, 2008, 57 Suppl 3: S49-S57. DOI: 10.33549/physiolres.931600
[2] CONOR C SMITH David H F Terrell T Gibbs. Pregnenolone sulfate as a modulator of synaptic plasticity.[J]. Psychopharmacology, 2014, 231 17: 3537-3556. DOI: 10.1007/s00213-014-3643-x
[3] GERALD THIEL Oliver G R Isabelle Müller. Signal transduction via TRPM3 channels in pancreatic β-cells.[J]. Journal of molecular endocrinology, 2013, 50 3: R75-83. DOI: 10.1530/jme-12-0237
PREGNENOLONE SULFATE SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
PREGNENOLONE SULFATE SODIUM SALT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53799 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89667 | 60 |
| Beijing Minruida Technology Co., Ltd. | 010-82387566 | sales@mreda.com.cn | China | 19323 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
View Lastest Price from PREGNENOLONE SULFATE SODIUM SALT manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Pregnenolone monosulfate sodium
1852-38-6
|
99.76% | 10g | TargetMol Chemicals Inc. |
-
- Pregnenolone monosulfate sodium
1852-38-6
- $0.00
- 99.76%
- TargetMol Chemicals Inc.
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