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BIS(2,2,2-TRIFLUOROETHYL) ETHER

BIS(2,2,2-TRIFLUOROETHYL) ETHER structure

CAS No.: 333-36-8

Chemical Name:: BIS(2,2,2-TRIFLUOROETHYL) ETHER

Synonyms: HFE;FLUROTHYL;SF6539;SKL232;Idoklon;skf6539;Flurotyl;Indiklon;Indoklon;SKF 6539

CBNumber:: CB8723208

Molecular Formula:: C4H4F6O

Molecular Weight:: 182.06

MDL Number:: MFCD00010604

MOL File:: 333-36-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-22 18:57:36

Product description	Number	Pack Size	Price
Bis(2,2,2-trifluoroethyl) ether 98%	287571	5g	$124
Bis(2,2,2-trifluoroethyl) Ether >99.0%(GC)	B1293	1g	$59
Bis(2,2,2-trifluoroethyl) Ether >99.0%(GC)	B1293	5g	$163
Bis(2,2,2-trifluoroethyl) Ether	B585665	500mg	$70
Bis(2,2,2-trifluoroethyl) Ether	B585665	50mg	$40

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BIS(2,2,2-TRIFLUOROETHYL) ETHER Properties

Melting point	25°C
Boiling point	62-63 °C (lit.)
Density	1.404 g/mL at 25 °C (lit.)
refractive index	n20/D 1.300(lit.)
Flash point	35 °F
storage temp.	Flammables area
solubility	DMSO : ≥ 125 mg/mL (686.59 mM)
form	clear liquid
color	Colorless to Almost colorless
Specific Gravity	1.41
Merck	14,4201
BRN	1811927
Henry's Law Constant	9.2×10^-3 mol/(m³Pa) at 25℃, Fukuchi et al. (2002)
InChI	InChI=1S/C4H4F6O/c5-3(6,7)1-11-2-4(8,9)10/h1-2H2
InChIKey	KGPPDNUWZNWPSI-UHFFFAOYSA-N
SMILES	O(CC(F)(F)F)CC(F)(F)F
CAS DataBase Reference	333-36-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	9Z467FG2YK
EPA Substance Registry System	HFE-356mff2 (333-36-8)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Danger

Hazard statements

H225-H315-H319-H335

Precautionary statements

P210-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves

Hazard Codes

F,Xi,T

Risk Statements

11-36/37/38

Safety Statements

16-26-36

RIDADR

UN 3271 3/PG 2

WGK Germany

RTECS

KN3675000

Hazard Note

Flammable/Toxic/Convulsant

HazardClass

3.1

PackingGroup

HS Code

29091990

Storage Class

3 - Flammable liquids

Hazard Classifications

Eye Irrit. 2
Flam. Liq. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	3
2		0

BIS(2,2,2-TRIFLUOROETHYL) ETHER price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	287571	Bis(2,2,2-trifluoroethyl) ether 98%	333-36-8	5g	$124	2026-03-19	Buy
TCI Chemical	B1293	Bis(2,2,2-trifluoroethyl) Ether >99.0%(GC)	333-36-8	1g	$59	2026-03-19	Buy
TCI Chemical	B1293	Bis(2,2,2-trifluoroethyl) Ether >99.0%(GC)	333-36-8	5g	$163	2026-03-19	Buy
TRC	B585665	Bis(2,2,2-trifluoroethyl) Ether	333-36-8	500mg	$70	2021-12-16	Buy
TRC	B585665	Bis(2,2,2-trifluoroethyl) Ether	333-36-8	50mg	$40	2021-12-16	Buy

Product number	Packaging	Price	Buy
287571	5g	$124	Buy
B1293	1g	$59	Buy
B1293	5g	$163	Buy
B585665	500mg	$70	Buy
B585665	50mg	$40	Buy

BIS(2,2,2-TRIFLUOROETHYL) ETHER Chemical Properties,Uses,Production

Chemical Properties

clear colorless liquid

Originator

Indoklon ,Ohio Medical, US ,1964

Uses

5HT agonist

Uses

Bis(2,2,2-trifluoroethyl) ether was used to diminish self-discharge of Li-S cells having both low- and high-sulfur-loading sulfur cathodes.

Uses

Bis(2,2,2-trifluoroethyl) Ether is Prophylactic and/or therapeutic agent for Alzheimer''s disease.

Definition

ChEBI: Flurotyl is an ether.

Manufacturing Process

23 parts of sodium metal were placed in 300 parts of dry dioxane in a reactor equipped with an agitator and reflux condenser. The dioxane was heated to reflux while stirring.150 parts of 2,2,2-trifluoroethanol were added very slowly in the period of about 1 hour, or until the sodium was all reacted, to form sodium 2,2,2-trifluoroethylate. 250 parts of 2,2,2-trifluoroethyl ptoluenesulfonate prepared by reacting 2,2,2-trifluoroethanol with p Flurothyl toluenesulfonyl chloride were placed in another reactor and heated to about 160° to 185°C. The solution of sodium 2,2,2-trifluoroethylate in dioxane was added very slowly over a period of about 1 hours. Bis(2,2,2-trifluoroethyl) ether formed continuously and distilled from the reactor with the dioxane into a cooled receiving vessel. The condensed effluent from the reactor was fractionally distilled, yielding 46.5 parts of products boiling at 55° to 73°C.
The crude product was washed successively with concentrated HCl, 62% H2SO4,concentrated H2SO4 and 5% NaOH solution. It was dehydrated over a drying agent and then refractionated in a still. 20 parts of bis(2,2,2trifluoroethyl) ether were recovered (BP 62.5° to 63.5°C).

brand name

Indoklon (Ohmeda).

Therapeutic Function

Central stimulant, Convulsant

BIS(2,2,2-TRIFLUOROETHYL) ETHER synthesis

Synthesis of BIS(2,2,2-TRIFLUOROETHYL) ETHER from 2,2,2-Trifluoroethanol

BIS(2,2,2-TRIFLUOROETHYL) ETHER Preparation Products And Raw materials

Raw materials

Tosyl chloride Sodium NSC 117816 sodium 2,2,2-trifluoroethanolate Diglycolic acid

Trifluoroacetic anhydride

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Preparation Products

1,1,1,2-Tetrafluoroethane

BIS(2,2,2-TRIFLUOROETHYL) ETHER Suppliers

Global( 128)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hong Kong Pure Biotechnology LIMITED	+86-44-7899295894 +8613639316680	hannah_7@pure-chem.net	China	221	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21591	55
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5742	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	17259	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39040	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43333	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58

Supplier	Advantage
Hong Kong Pure Biotechnology LIMITED	58
Henan Fengda Chemical Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shenzhen Nexconn Pharmatechs Ltd	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
CD Chemical Group Limited	58
TargetMol Chemicals Inc.	58
HANGZHOU LEAP CHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58

View Lastest Price from BIS(2,2,2-TRIFLUOROETHYL) ETHER manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-22	Fluorothyl 333-36-8	US $60.00-30.00 / mg		98.00%	10g	TargetMol Chemicals Inc.
2026-04-22	Fluorothyl 333-36-8	US $60.00-30.00 / mg		98.00%	10g	TargetMol Chemicals Inc.
2025-09-25	Fluorothyl 333-36-8	US $30.00-0.90 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

Fluorothyl
333-36-8
US $60.00-30.00 / mg
98.00%
TargetMol Chemicals Inc.

Fluorothyl
333-36-8
US $60.00-30.00 / mg
98.00%
TargetMol Chemicals Inc.

Fluorothyl
333-36-8
US $30.00-0.90 / KG
99%
Henan Fengda Chemical Co., Ltd

BIS(2,2,2-TRIFLUOROETHYL) ETHER Spectrum

BIS(2,2,2-TRIFLUOROETHYL) ETHER(333-36-8)MS BIS(2,2,2-TRIFLUOROETHYL) ETHER(333-36-8)¹HNMR BIS(2,2,2-TRIFLUOROETHYL) ETHER(333-36-8)¹³CNMR BIS(2,2,2-TRIFLUOROETHYL) ETHER(333-36-8)IR1 BIS(2,2,2-TRIFLUOROETHYL) ETHER(333-36-8)Raman

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Di(2,2,2-trifluroethyl)ether Bis(2,2,2-trifluoroethyl) ether 99% Bis(2,2,2-trifluoroethyl)ether99% 2,2,2-TRIFLUOROETHYL ETHER 99% 2,2,2-Trifluoroethyl ether, Flurothyl 1,1'-Oxybis(2,2,2-trifluoroethane) 2,2,2-Trifluoroethyl ether,99% 1,1,1-Trifluoro-2-(2,2,2-trifluoroethoxy)ethane 2-(2,2,2-Trifluoroethoxy)-1,1,1-trifluoroethane Bis(trifluoroethyl)ether Ethane, 1,1'-oxybis[2,2,2-trifluoro- Ether, bis(2,2,2-trifluoroethyl) ether,bis(2,2,2-trifluoroethyl) Fluoroethyl Fluorothyl Flurotyl Hexafluorodiethyl ether hexafluorodiethylether Idoklon Indiklon Indoklon SF6539 SK&F-6539 SKF 6539 skf6539 2,2,2-TRIFLUOROETHYL ETHER BIS(2,2,2-TRIFLUOROETHYL) ETHER DI(2,2,2-TRIFLUOROETHYL)ETHER 2-trifluoroethyl) ether Bis(2,2,2-trifluoroethyl) Ether > 2,2,2-Trifluorodiethyl ether SKL232 inhibit,Fluorothyl,Inhibitor Fluorothyl, 10 mM in DMSO HFE FLUROTHYL 333-36-8 CF3CH22O Building Blocks Oxygen Compounds Organic Building Blocks Ethers IMITREX