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4-HYDROXY-3-NITROPHENYLACETIC ACID

4-HYDROXY-3-NITROPHENYLACETIC ACID structure

CAS No.: 10463-20-4

Chemical Name:: 4-HYDROXY-3-NITROPHENYLACETIC ACID

Synonyms: TIMTEC-BB SBB007785;3-NITRO-4-HYDROXYPHENYLACETIC ACID;4-HYDROXY-3-NITROPHENYLACETIC ACID;4-Hydroxy-3-nitrobenzeneacetic acid;4-Hydroxy-3-nitrophenylaceticAcid>Benzeneacetic acid, 4-hydroxy-3-nitro-;2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID;4-Hydroxy-3-nitrophenylacetic acid,99%;4-Hydroxy-3-nitrophenylacetic acid 98%;4-Hydroxy-3-nitrophenylacetic acid, 10 mM in DMSO

CBNumber:: CB8737517

Molecular Formula:: C8H7NO5

Molecular Weight:: 197.14

MDL Number:: MFCD00007122

MOL File:: 10463-20-4.mol

MSDS File:: SDS

Last updated:2026-04-14 09:55:04

Product description	Number	Pack Size	Price
4-Hydroxy-3-nitrophenylacetic acid 99%	219924	1g	$56.3
4-Hydroxy-3-nitrophenylacetic Acid >98.0%(T)	H1362	1g	$50
4-Hydroxy-3-nitrophenylacetic Acid >98.0%(T)	H1362	5g	$151
4-Hydroxy-3-nitrophenylacetic acid	279309	50mg	$425
4-Hydroxy-3-nitrophenylacetic Acid	H948685	1g	$105

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4-HYDROXY-3-NITROPHENYLACETIC ACID Properties

Melting point	146-148 °C (lit.)
Boiling point	334.23°C (rough estimate)
Density	1.5023 (rough estimate)
refractive index	1.5700 (estimate)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	ethanol: soluble5%, clear, yellow to orange
pka	4.25±0.10(Predicted)
form	crystalline
color	yellow
BRN	2696044
InChI	1S/C8H7NO5/c10-7-2-1-5(4-8(11)12)3-6(7)9(13)14/h1-3,10H,4H2,(H,11,12)
InChIKey	QBHBHOSRLDPIHG-UHFFFAOYSA-N
SMILES	OC(=O)Cc1ccc(O)c(c1)[N+]([O-])=O
CAS DataBase Reference	10463-20-4(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

TSCA

HazardClass

IRRITANT

HS Code

29182900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

4-HYDROXY-3-NITROPHENYLACETIC ACID price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	219924	4-Hydroxy-3-nitrophenylacetic acid 99%	10463-20-4	1g	$56.3	2026-03-19	Buy
TCI Chemical	H1362	4-Hydroxy-3-nitrophenylacetic Acid >98.0%(T)	10463-20-4	1g	$50	2026-03-19	Buy
TCI Chemical	H1362	4-Hydroxy-3-nitrophenylacetic Acid >98.0%(T)	10463-20-4	5g	$151	2026-03-19	Buy
Usbiological	279309	4-Hydroxy-3-nitrophenylacetic acid	10463-20-4	50mg	$425	2021-12-16	Buy
TRC	H948685	4-Hydroxy-3-nitrophenylacetic Acid	10463-20-4	1g	$105	2021-12-16	Buy

Product number	Packaging	Price	Buy
219924	1g	$56.3	Buy
H1362	1g	$50	Buy
H1362	5g	$151	Buy
279309	50mg	$425	Buy
H948685	1g	$105	Buy

4-HYDROXY-3-NITROPHENYLACETIC ACID Chemical Properties,Uses,Production

Chemical Properties

yellow crystalline powder

Uses

A metabolite of Nitrotyrosine (N597000), which is excreted in the urine.

Uses

4-Hydroxy-3-nitrophenylacetic acid was used in the synthesis of 4-hydroxy-3-nitrophenylacetyl caproic acid.

Definition

ChEBI: (4-hydroxy-3-nitrophenyl)acetic acid is a monocarboxylic acid that is acetic acid carrying a 2-hydroxy-3-nitrophenyl substituent at C-2. It has a role as a hapten. It is a conjugate acid of a (4-hydroxy-3-nitrophenyl)acetate.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 30, p. 1166, 1987 DOI: 10.1021/jm00390a009

General Description

4-Hydroxy-3-nitrophenylacetic acid enhances the ice-nucleation activity of Xanthomonas campestris.

Synthesis

156-38-7

10463-20-4

General procedure for the synthesis of 4-hydroxy-3-nitrophenylacetic acid from p-hydroxyphenylacetic acid: (a) Nitration reaction: fuming nitric acid (1.36 mL) was slowly added dropwise to a solution of 4-hydroxyphenylacetic acid (4.00 g, 26.3 mmol) in acetic acid (25 mL) under cooling in an ice bath. After the dropwise addition was completed, the reaction mixture was slowly warmed up to room temperature and reacted for 1 hour, during which time the solution gradually changed from yellow to brown color, accompanied by the formation of a precipitate. After completion of the reaction, the solid product was collected by filtration and recrystallized from ethyl acetate/hexane mixed solvent to obtain yellow needle-like crystals of 4-hydroxy-3-nitrophenylacetic acid (3.61 g, 70% yield). The structure of the product was confirmed by 1H-NMR: δ (CDCl3-d4/DMSO, 4:1) 3.50 (2H, s), 7.04 (1H, d, J = 9 Hz), 7.46 (1H, dd, J = 9, 3 Hz), 7.94 (1H, d, J = 3 Hz).

References

[1] Synthetic Communications, 1985, vol. 15, # 12, p. 1075 - 1080
[2] Patent: US5229510, 1993, A
[3] Journal of Medicinal Chemistry, 1987, vol. 30, # 7, p. 1166 - 1176
[4] Patent: US9995679, 2018, B2. Location in patent: Page/Page column 52
[5] Patent: US5852191, 1998, A

4-HYDROXY-3-NITROPHENYLACETIC ACID Preparation Products And Raw materials

Raw materials

Ethanol 4-Hydroxybenzyl cyanide Potassium hydroxide Ethyl acetate Nitric acid

Acetic acid PETROLEUM ETHER Sulfuric acid 4-Hydroxyphenylacetic acid

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Preparation Products

(4-METHOXY-3-NITROPHENYL)ACETIC ACID Methyl (4-Hydroxy-3-nitrophenyl)acetate 2-(2-METHYL-1,3-BENZOXAZOL-5-YL)ACETIC ACID

4-HYDROXY-3-NITROPHENYLACETIC ACID Suppliers

Global( 171)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58
Kindchem(Nanjing)Co.,Ltd	+86-025-025-85281586 +8618651653755	sales@kindchem.cn	China	1226	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14304	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	10000	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58
Kindchem(Nanjing)Co.,Ltd	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Win-Win chemical CO., Limited	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from 4-HYDROXY-3-NITROPHENYLACETIC ACID manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-13	4-Hydroxy-3-nitrophenylacetic acid 10463-20-4	US $46.00-85.00 / mg		99.17%	10g	TargetMol Chemicals Inc.
2026-03-20	2-(4-hydroxy-3-nitrophenyl)acetic acid 10463-20-4	US $0.00 / kg	20kg	99%	20 tons	Qingdao RENAS Polymer Material Co., Ltd.
2025-09-25	4-HYDROXY-3-NITROPHENYLACETIC ACID 10463-20-4	US $100.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

4-Hydroxy-3-nitrophenylacetic acid
10463-20-4
US $46.00-85.00 / mg
99.17%
TargetMol Chemicals Inc.

2-(4-hydroxy-3-nitrophenyl)acetic acid
10463-20-4
US $0.00 / kg
99%
Qingdao RENAS Polymer Material Co., Ltd.

4-HYDROXY-3-NITROPHENYLACETIC ACID
10463-20-4
US $100.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

4-HYDROXY-3-NITROPHENYLACETIC ACID Spectrum

4-HYDROXY-3-NITROPHENYLACETIC ACID(10463-20-4)MS 4-HYDROXY-3-NITROPHENYLACETIC ACID(10463-20-4)¹HNMR 4-HYDROXY-3-NITROPHENYLACETIC ACID(10463-20-4)IR1 4-HYDROXY-3-NITROPHENYLACETIC ACID(10463-20-4)IR2

10463-20-4(4-HYDROXY-3-NITROPHENYLACETIC ACID)Related Search:

4-HYDROXY-2-METHYLBENZOIC ACID 98 2-Bromo-5-chlorophenylacetic acid 3-NITROPHENYLACETIC ACID 2-HYDROXY-5-NITROPHENYLACETIC ACID 4-METHOXY-3-NITRO-BENZENEACETIC ACID METHYL ESTER

[4-(BENZYLOXY)-3-NITROPHENYL]ACETIC ACID AMINO-(4-HYDROXY-3-NITRO-PHENYL)-ACETIC ACID (4-METHOXY-3-NITROPHENYL)ACETIC ACID (2R)-2-AMINO-2-(4-METHOXY-3-NITROPHENYL)PROPANOIC ACID 4-HYDROXY-3-NITROPHENYLACETIC ACID

3,5-DINITRO-4-HYDROXYPHENYLACETIC ACID (4-ETHOXY-3-NITROPHENYL)ACETIC ACID 4-HYDROXY-3-IODO-5-NITRO-PHENYLACETIC ACID AMINO-(4-HYDROXY-3-METHOXY-5-NITRO-PHENYL)-ACETIC ACID (2S)-2-AMINO-2-(4-METHOXY-3-NITROPHENYL)PROPANOIC ACID

Methyl (4-Hydroxy-3-nitrophenyl)acetate

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4-Hydroxy-3-nitrophenylacetic acid 98% 3-NITRO-4-HYDROXYPHENYLACETIC ACID 4-Hydroxy-3-nitrobenzeneacetic acid 4-Hydroxy-3-nitrophenylacetic acid,99% 2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID 4-HYDROXY-3-NITROPHENYLACETIC ACID Benzeneacetic acid, 4-hydroxy-3-nitro- TIMTEC-BB SBB007785 4-Hydroxy-3-nitrophenylaceticAcid> 4-HYDROXY-3-NITROPHENYLACETIC ACID ISO 9001：2015 REACH 4-Hydroxy-3-nitrophenylacetic acid, 10 mM in DMSO 10463-20-4 HOC6H3NO2CH2CO2H C8 Carboxylic Acids Carbonyl Compounds Building Blocks Organic Building Blocks Aromatics Metabolites & Impurities C8 Carbonyl Compounds Carboxylic Acids Phenyls & Phenyl-Het Carboxylic Acids Phenyls & Phenyl-Het Aromatics, Metabolites & Impurities Aromatic Phenylacetic Acids and Derivatives