Tetrabutylammonium Fluoride
- CAS No.
- 429-41-4
- Chemical Name:
- Tetrabutylammonium Fluoride
- Synonyms
- TBAF;TABF;TBAF in THF;TETRABUTYLAMMONIUM FLUORIDE HYDRATE;Tetrabutylammonium fluoride solution;Tetra-n-butyL;Tetrabutylammonium Fluoride (1mol/L in Tetrahydrofuran) [for Catalyst of acylation, silylation and cleavage of Silyl Ether];Tetrabutylazanium fluoride;Tetrabutylammonium Fluoride (TBAF);TETRABUTYL AMMONIUM FLUORIDE IN THF (I M)
- CBNumber:
- CB8740854
- Molecular Formula:
- C16H36FN
- Molecular Weight:
- 261.46
- MDL Number:
- MFCD00149980
- MOL File:
- 429-41-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Tetrabutylammonium fluoride solution 1.0 M in THF | 216143 | 1l | $547 |
| Tetrabutylammonium fluoride solution 1.0 M in THF | 216143 | 2.5l | $1120 |
| Tetrabutylammonium Fluoride (ca. 1mol/L in Tetrahydrofuran)[for Catalyst of acylation, silylation and cleavage of Silyl Ether] | T1125 | 25mL | $54 |
| Tetrabutylammonium Fluoride (ca. 1mol/L in Tetrahydrofuran)[for Catalyst of acylation, silylation and cleavage of Silyl Ether] | T1125 | 100mL | $129 |
| Tetrabutylammonium fluoride, 1M in THF | 02-5012 | 0.05mole | $63 |
| More product size | |||
| Melting point | 62-63 °C(lit.) |
|---|---|
| Density | 0.953 g/mL at 25 °C |
| refractive index |
n |
| Flash point | 1 °F |
| storage temp. | 2-8°C |
| solubility | Miscible with terahydrofuran, acetonitrile, dimethyl sulfoxide and organic solvents. |
| form | Solution |
| color | Clear light greenish to brown |
| Water Solubility | Insoluble in water. |
| Sensitive | Hygroscopic |
| Merck | 14,9187 |
| BRN | 3570522 |
| Exposure limits |
ACGIH: TWA 2.5 mg/m3 NIOSH: IDLH 250 mg/m3 |
| InChI | 1S/C16H36N.FH/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;/h5-16H2,1-4H3;1H/q+1;/p-1 |
| InChIKey | FPGGTKZVZWFYPV-UHFFFAOYSA-M |
| SMILES | [F-].CCCC[N+](CCCC)(CCCC)CCCC |
| CAS DataBase Reference | 429-41-4(CAS DataBase Reference) |
| FDA UNII | 2618F0C37I |
| EPA Substance Registry System | 1-Butanaminium, N,N,N-tributyl-, fluoride (429-41-4) |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H411 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C,F,Xi | |||||||||
| Risk Statements | 34-19-11-36/37/38-40-37 | |||||||||
| Safety Statements | 26-27-36/37/39-45-33-29-16-36 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3 | |||||||||
| Hazard Note | Flammable/Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29239000 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 3 Eye Irrit. 2 Repr. 2 Skin Irrit. 2 |
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| Limited Quantities | 1.0 L (0.3 gallon) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Tetrabutylammonium Fluoride price More Price(104)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 216143 | Tetrabutylammonium fluoride solution 1.0 M in THF | 429-41-4 | 1l | $547 | 2026-04-30 | Buy |
| Sigma-Aldrich | 216143 | Tetrabutylammonium fluoride solution 1.0 M in THF | 429-41-4 | 2.5l | $1120 | 2026-04-30 | Buy |
| TCI Chemical | T1125 | Tetrabutylammonium Fluoride (ca. 1mol/L in Tetrahydrofuran)[for Catalyst of acylation, silylation and cleavage of Silyl Ether] | 429-41-4 | 25mL | $54 | 2026-04-30 | Buy |
| TCI Chemical | T1125 | Tetrabutylammonium Fluoride (ca. 1mol/L in Tetrahydrofuran)[for Catalyst of acylation, silylation and cleavage of Silyl Ether] | 429-41-4 | 100mL | $129 | 2026-04-30 | Buy |
| Strem Chemicals | 02-5012 | Tetrabutylammonium fluoride, 1M in THF | 429-41-4 | 0.05mole | $63 | 2026-04-30 | Buy |
Tetrabutylammonium Fluoride Chemical Properties,Uses,Production
Chemical Properties
Clear light greenish to amber or brown solution
Uses
Catalyst for etherification of alcohols and phenols with alkyl halides Catalyst for benzylation reactions.
Uses
Tetrabutylammonium fluoride is a reagent in organic syntheses in addition, condensation, base-catalyzed cyclization reactions, fluorination and desulfonylation reactions and as a deprotecting agent. Typically dried prior to use.
Uses
Tetrabutylammonium fluoride (TBAF) is a commonly used organic soluble fluoride salt. It is used as a base, a phase transfer catalyst, and as a fluoride source. In the research field of fluoride sensor development, TBAF is used as an easy to handle and measurable fluoride anion source. The fluoride in TBAF, once dissolved, can be thought of as a free fluoride with little interaction with the ammonium cation. Since TBAF should not absorb light at wavelengths greater than 240nm, it is useful to monitor sensing reactions with visible spectroscopy.
Definition
ChEBI: Tetrabutylammonium fluoride is a fluoride salt and a tetrabutylammonium salt. It has a role as a phase-transfer catalyst.
Synthesis
392-56-3
10442-39-4
1217-44-3
429-41-4
Synthesis of TBAF; Anhydrous tetrabutylammonium fluoride (TBAF):; 0.67 g of tetrabutylammonium cyanide (TBACN) was dissolved in 2.5 ml of tetrahydrofuran (THF) and the resulting solution was cooled to -65 °C. In a separate vessel, 0.3 mL of hexafluorobenzene (C6F6) was dissolved in 0.5 mL of THF and cooled to -65°C. The hexafluorobenzene solution was slowly added to the cooled TBACN solution and the mixture was gradually warmed (over 4 hours) to -15°C. During the reaction, the solution changed from colorless to yellow-green and precipitated a white solid. The mixture was cooled again to -65 °C, the solid was collected by filtration and washed twice with cold THF. All separation operations need to be carried out below -36°C. The resulting white or light yellow TBAF solid can be stored in a refrigerator at -36°C for a short period of time. If the reaction mixture is used directly, the overall yield of TBAF exceeds 95% (based on TBACN, as verified by burst experiments with benzyl chloride). Isolated yields of the solid product ranged from 40% to 70%, depending on the efficiency of the washing and filtration steps.1H NMR ((CD3)2SO) δ 3.23 (8H, m), 1.56 (8H, m), 1.28 (8H, sextuple peak, J = 7.31 Hz), 0.86 (12H, t, J = 7.31 Hz); 19F NMR ((CD3)2SO) δ -72.6 ppm(s); 13C NMR ((CD3)2SO) δ 57.5, 23.1, 19.2, 13.5 ppm.
References
[1] Patent: US2006/89514, 2006, A1. Location in patent: Page/Page column 5
Tetrabutylammonium Fluoride Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Shandong Juchuang Chemical Co., LTD | +16837774622 | admin@juchuangchem.com | China | 295 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
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View Lastest Price from Tetrabutylammonium Fluoride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | Tetrabutylammonium fluoride
429-41-4
|
$1.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-09-25 | Tetrabutylammonium fluoride
429-41-4
|
$1.00-50.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-04-15 | Tetranbutylammoniumfluoride
429-41-4
|
$70.00 | 1kg | 99 | 5000 | Hebei Zhuanglai Chemical Trading Co.,Ltd |
-
- Tetrabutylammonium fluoride
429-41-4
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Tetrabutylammonium fluoride
429-41-4
- $1.00-50.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Tetranbutylammoniumfluoride
429-41-4
- $70.00
- 99
- Hebei Zhuanglai Chemical Trading Co.,Ltd
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