Picroside II
- CAS No.
- 39012-20-9
- Chemical Name:
- Picroside II
- Synonyms
- AMPHICOSIDE;PICROSID II;Picroside-2;Picroside Ⅱ;PICROSIDE II;PICROSIDE ò;Picroside a…;Berberine II;AMPHICOSIDE II;Picroside II-RM
- CBNumber:
- CB8745879
- Molecular Formula:
- C23H28O13
- Molecular Weight:
- 512.46
- MDL Number:
- MFCD00017402
- MOL File:
- 39012-20-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Picroside II ≥98% (HPLC) | G0174 | 10mg | $362 |
| Picroside II ≥98% (HPLC) | G0174 | 50mg | $1170 |
| Picroside II | P2594 | 100MG | $345 |
| Picroside II | 30319 | 10mg | $73 |
| Picroside II | 30319 | 250mg | $717 |
| More product size | |||
| Melting point | 145 - 155oC |
|---|---|
| Boiling point | 780.8±60.0 °C(Predicted) |
| Density | 1.66±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | ethanol: soluble1mg/mL, clear, colorless |
| pka | 8.07±0.20(Predicted) |
| form | Solid |
| color | Pale Yellow |
| InChIKey | AKNILCMFRRDTEY-MRFBWRKESA-N |
| SMILES | C12(CO)OC1C(C1C=COC(O[C@H]3[C@H](O)[C@H]([C@H](O)[C@@H](CO)O3)O)C21)OC(=O)C1=CC=C(O)C(OC)=C1 |&1:12,13,15,16,18,r| |
| FDA UNII | XX0PFP9RVI |
| UNSPSC Code | 41116107 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29389090 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
Picroside II price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G0174 | Picroside II ≥98% (HPLC) | 39012-20-9 | 10mg | $362 | 2023-06-20 | Buy |
| Sigma-Aldrich | G0174 | Picroside II ≥98% (HPLC) | 39012-20-9 | 50mg | $1170 | 2023-06-20 | Buy |
| TCI Chemical | P2594 | Picroside II | 39012-20-9 | 100MG | $345 | 2025-07-31 | Buy |
| Cayman Chemical | 30319 | Picroside II | 39012-20-9 | 10mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 30319 | Picroside II | 39012-20-9 | 250mg | $717 | 2024-03-01 | Buy |
Picroside II Chemical Properties,Uses,Production
Uses
Picroside II similar to Picroside I (P437635), acts as an oxygen free radical scavenger and thus promotes anti-inflammatory activity and may be used in the treatment of arthritis or ischemic injury.
Chemical Properties
Yellow needle-shaped crystals, soluble in methanol, derived from Picrorhizoma Coptidis.
Uses
Picroside II similar to Picroside I (P437635), acts as an oxygen free radical scavenger and thus promotes anti-inflammatory activity and may be used in the treatment of arthritis or ischemic injury.
Definition
ChEBI: Picroside ii is a tannin.
Biological Activity
Picroside II displaysmany anti-cancer properties such as anti-metastatic, anti-angiogenic, and anti-apoptotic activities in both in vitro and in vivo studies.It also exerts antioxidant, anti-inflammatory, and antidiarrheal effectsagainst acute oxidative injuries such as severe acute pancreatitis-inducedintestinal barrier injury. PII has protective effects onischemia/reperfusion (I/R)-induced injury by interacting with differentmechanisms in various in vitro and in vivo models.', 'Phytochemical found in Traditional Chinese Medicine herbal preparations. Picroside II, a glucoside, is reported to have hepatoprotective, cardioprotective, and neuroprotective properties.
in vivo
Picroside II (0-20 mg/kg, i.g., given in two doses) protects liver cells from damage and prevents apoptosis[1].
Picroside II (20 mg/kg, intravenous injection, given in four doses) inhibits the activation of NLRP3 inflammasome and NF-κB pathway in mice, reducing the inflammatory response in sepsis and enhancing immune function[3].
Picroside II (20 mg/kg, intraperitoneal injection, a single dose) protects the blood-brain barrier by inhibiting oxidative signaling pathways in a rat model of ischemia-reperfusion injury[4].
Picroside II (5-20 mg/kg, i.g., once a day for seven days) has anti-lipid peroxidation effects and protects against mitochondrial damage in mice with liver injury[5].
| Animal Model: | DGalN and LPS(HY-D1056)-induced acute liver injury in mice[1] |
| Dosage: | 0, 5, 10, 20 mg/kg; administered 10 min before and 4 h after D-GalN and LPS administration |
| Administration: | i.g. |
| Result: | Reduced the levels of alanine aminotransferase and aspartate aminotransferase in the serum, decreased MDA content, had a dose-dependent effect on hepatocyte apoptosis, and upregulated the expression of the bcl-2 gene. |
| Animal Model: | Sepsis mouse model[3] |
| Dosage: | 20 mg/kg; four times injected (2 h, 14 h, 26 h and 38 h after CLP) |
| Administration: | Intravenous injection (i.v.) |
| Result: | Improved survival, reduced sepsis-related infiltration and attenuated lung injury, enhanced bacterial clearance, reduced IL-6, IL-1β, and TNF-α levels, inhibited splenic lymphocyte apoptosis, reduced p-NF-κB (p65) expression, and reduced IL-1β and caspase-1 levels. |
| Animal Model: | Rats with cerebral ischemia-reperfusion injury[4] |
| Dosage: | 20 mg/kg; single dose |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Reduced the nervous system score, neuronal injury, BBB damage, ROS content and NADPH oxidase activity, down-regulated the protein levels of Rac-1, Nox2, ROCK, MLCK and MMP-2, and up-regulated the expression of claudin-5. |
| Animal Model: | Mouse model of liver injury induced by CCl4, D-GalN and AP[5] |
| Dosage: | 5, 10, 20mg/kg; daily; 7 days |
| Administration: | i.g. |
| Result: | Reduced the high levels of ALT and AST in serum caused by CCl4, D-GalN and AP, significantly alleviated liver cell damage, reduced MDA, and increased SOD and GSH-Px content in a dose-dependent manner, inhibited AP-induced liver toxicity in mice, enhanced ATPase activity, and improved mitochondrial swelling. |
Picroside II Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21599 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
View Lastest Price from Picroside II manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-26 | Picroside II
39012-20-9
|
US $37.00-78.00 / mg | 99.68% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-04 | Picroside II
39012-20-9
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2023-02-24 | Picroside II
39012-20-9
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Picroside II
39012-20-9
- US $37.00-78.00 / mg
- 99.68%
- TargetMol Chemicals Inc.
-
- Picroside II
39012-20-9
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Picroside II
39012-20-9
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
