5-Iodouracil
- CAS No.
- 696-07-1
- Chemical Name:
- 5-Iodouracil
- Synonyms
- 5IU;NSC 57848;5-Iodouracl;5-IODOURACIL;5-iodo-uraci;5-iodine uracil;5-Iodouracil>5-Iodouracil,97%;5-Iodouracil ,99%;5-Iodouracil, 98%
- CBNumber:
- CB8771577
- Molecular Formula:
- C4H3IN2O2
- Molecular Weight:
- 237.98
- MDL Number:
- MFCD00006020
- MOL File:
- 696-07-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Iodouracil 98% | 857858 | 10g | $84.5 |
| 5-Iodouracil >99.0%(HPLC)(T) | I0219 | 5g | $53 |
| 5-Iodouracil >99.0%(HPLC)(T) | I0219 | 25g | $137 |
| 5-Iodouracil | 014915 | 25g | $403 |
| 5-Iodouracil | 280333 | 50g | $333 |
| More product size | |||
| Melting point | 274-276 °C (dec.) (lit.) |
|---|---|
| Density | 2.2076 (estimate) |
| storage temp. | 2-8°C |
| solubility | Very faint turbidity in NH3aq. Soluble in 1M NaOH. |
| pka | 7.02±0.10(Predicted) |
| form | Fluffy Powder |
| color | White to light yellow |
| Water Solubility | SOLUBLE IN COLD WATER |
| Sensitive | Light Sensitive |
| BRN | 4891 |
| InChI | InChI=1S/C4H3IN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9) |
| InChIKey | KSNXJLQDQOIRIP-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=C(I)C(=O)N1 |
| CAS DataBase Reference | 696-07-1(CAS DataBase Reference) |
| FDA UNII | H59BRK500M |
| NIST Chemistry Reference | 5-Iodouracil(696-07-1) |
| EPA Substance Registry System | 2,4(1H,3H)-Pyrimidinedione, 5-iodo- (696-07-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T,Xi | |||||||||
| Risk Statements | 46-20/21/22-36/37/38 | |||||||||
| Safety Statements | 53-22-26-36/37/39-45 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YR0525000 | |||||||||
| Hazard Note | Irritant/Carcinogenic/Light Sensitive | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-Iodouracil price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 857858 | 5-Iodouracil 98% | 696-07-1 | 10g | $84.5 | 2026-03-19 | Buy |
| TCI Chemical | I0219 | 5-Iodouracil >99.0%(HPLC)(T) | 696-07-1 | 5g | $53 | 2026-03-19 | Buy |
| TCI Chemical | I0219 | 5-Iodouracil >99.0%(HPLC)(T) | 696-07-1 | 25g | $137 | 2026-03-19 | Buy |
| Usbiological | 014915 | 5-Iodouracil | 696-07-1 | 25g | $403 | 2021-12-16 | Buy |
| Usbiological | 280333 | 5-Iodouracil | 696-07-1 | 50g | $333 | 2021-12-16 | Buy |
5-Iodouracil Chemical Properties,Uses,Production
Chemical Properties
white to light yellow fluffy powder
Uses
5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studies show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones.
Definition
ChEBI: An organoiodine compound consisting of uracil having an iodo substituent at the 5-position.
Synthesis
66-22-8
696-07-1
The general procedure for the synthesis of 5-iodouracil (5-IUra) from pyrimidine-2,4(1H,3H)-dione (Ura) is as follows: Example 1 Synthesis of 5-halogenated uracil (5-X-Ura) Preparation of 5-iodouracil (5-IUra) and 5-bromouracil (5-BrUra) from Ura: 1. Prepare a solution of 1,3,4,6-tetrachloro-3a,6a-diphenylglycuronium in chloroform (concentration 0.5 mg/mL). All reagents were available from Sigma Chemical Co. (St. Louis, MO) unless otherwise noted. 2. Dry 0.5 mL (containing 250 μg, 578 μmol) of the above solution using a stream of nitrogen. 3. 300 μL of Ura (2610 μmol, 8.7 M, dissolved in 0.25 M potassium phosphate buffer, pH 7.5) was added. 4. 100 μL NaI or NaBr (670 μmol, 6.7 M aqueous solution) was subsequently added to the reaction system. 5. The reaction mixture was heated at 60 °C for 15 min. 6. Upon completion of the reaction, the yield was 79% for 5-IUra and 56% for 5-BrUra, depending on the halide used. 7. At the end of the reaction, the reaction mixture was diluted with water and the products were analyzed by reversed-phase high performance liquid chromatography (HPLC). 8. HPLC mobile phase conditions: 20-50 mM acetic acid and 6-16% acetonitrile (ACN). Note: This method is suitable for the synthesis of materials on a small scale and also for the therapeutic isotope labeling of Ura by replacing non-radioactive halides with radioisotopes such as [82Br] or [125I].
References
[1] Tetrahedron Letters, 2002, vol. 43, # 8, p. 1381 - 1386
[2] Synlett, 2005, # 8, p. 1263 - 1266
[3] Helvetica Chimica Acta, 2015, vol. 98, # 7, p. 953 - 960
[4] Synthesis, 2004, # 11, p. 1869 - 1873
[5] Synthesis, 1995, # 8, p. 926 - 928
5-Iodouracil Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29822 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Beijing Ribio Biotech Co.,Ltd | 010-62664360 +8613328773880 | wucy@ribio.com.cn | China | 117 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
View Lastest Price from 5-Iodouracil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-04-13 | 5-Iodouracil
696-07-1
|
US $0.00-0.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2025-04-04 | 5-Iodouracil
696-07-1
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | |
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2022-02-25 | 5-Iodouracil
696-07-1
|
US $100.00 / Kg/Bag | 1KG | 99% | 100KG | Hong Kong Tiansheng New Material Trading Co., Ltd |
-
- 5-Iodouracil
696-07-1
- US $0.00-0.00 / mg
- TargetMol Chemicals Inc.
-
- 5-Iodouracil
696-07-1
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 5-Iodouracil
696-07-1
- US $100.00 / Kg/Bag
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
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