Chlorodifluoroacetic acid ethyl ester
- CAS No.
- 383-62-0
- Chemical Name:
- Chlorodifluoroacetic acid ethyl ester
- Synonyms
- Ethyl 2-chloro-2,2-difluoroacetate;ETHYL CHLORODIFLUOROACETATE;Difluorochlorate;Ethyl Difluorochloroacetate;Ethyl chlorodifluoroethanoate;Ethylchlorodifluoroacetate,98%;Ethyl chloroacetatetwo fluorine;Ethyl chlorodifluoroacetate 98%;Ethyl Chlorodifluoroacetate >chlorodifluoro-aceticaciethylester
- CBNumber:
- CB8772600
- Molecular Formula:
- C4H5ClF2O2
- Molecular Weight:
- 158.53
- MDL Number:
- MFCD00013662
- MOL File:
- 383-62-0.mol
- MSDS File:
- SDS
| Boiling point | 96-97.5 °C (lit.) |
|---|---|
| Density | 1.252 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 65 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Sparingly) |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Specific Gravity | 1.252 |
| Sensitive | Moisture Sensitive |
| BRN | 1761413 |
| InChI | InChI=1S/C4H5ClF2O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3 |
| InChIKey | GVCAWQUJCHZRCB-UHFFFAOYSA-N |
| SMILES | C(OCC)(=O)C(Cl)(F)F |
| CAS DataBase Reference | 383-62-0(CAS DataBase Reference) |
| EPA Substance Registry System | Acetic acid, chlorodifluoro-, ethyl ester (383-62-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H314 | |||||||||
| Precautionary statements | P210-P233-P240-P280-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | F,C,Xi | |||||||||
| Risk Statements | 11-34-20/21/22 | |||||||||
| Safety Statements | 16-26-27-36/37/39-45 | |||||||||
| RIDADR | UN 2924 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Flammable | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29159000 | |||||||||
| NFPA 704 |
|
Chlorodifluoroacetic acid ethyl ester price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 469599 | Ethyl chlorodifluoroacetate 98% | 383-62-0 | 25ml | $98.9 | 2025-07-31 | Buy |
| TCI Chemical | C1458 | Ethyl Chlorodifluoroacetate >97.0%(GC) | 383-62-0 | 25g | $79 | 2025-07-31 | Buy |
| TCI Chemical | C1458 | Ethyl Chlorodifluoroacetate >97.0%(GC) | 383-62-0 | 500g | $537 | 2025-07-31 | Buy |
| American Custom Chemicals Corporation | HCH0026101 | ETHYL CHLORODIFLUOROACETATE 95.00% | 383-62-0 | 25G | $1061.33 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0026101 | ETHYL CHLORODIFLUOROACETATE 95.00% | 383-62-0 | 100G | $2368.21 | 2021-12-16 | Buy |
Chlorodifluoroacetic acid ethyl ester Chemical Properties,Uses,Production
Chemical Properties
clear colorless liquid
Uses
Ethyl chlorodifluoroacetate (ECDFA) may be used as a starting reagent in the synthesis of 3-gem-difluoro-2-ethoxy allylic alcohols.
General Description
Ethyl chlorodifluoroacetate (ECDFA) undergoes Reformatskii reaction with various aldehydes in DMF. It reacts with phenylacetylene to afford ethyl α,α?difluoro-4-phenyl-3-butenoates.
Synthesis
64-17-5
76-04-0
383-62-0
General procedure for the synthesis of ethyl difluorochloroacetate from ethanol and difluorochloroacetic acid: 504.3 g (3.87 mmol) of difluorochloroacetic acid and 5.0 g of p-toluenesulfonic acid were dissolved in 775 mL of dichloromethane, and 311.6 g (6.76 mol) of ethanol was slowly added over a 30-minute period at room temperature (the temperature was raised to 33 °C during the reaction). The mixture was assembled to a water condenser and stirred at reflux for 38 hours and then cooled to room temperature. The reaction mixture was washed sequentially with 200 mL of water, 200 mL of saturated sodium bicarbonate solution and 200 mL of water, followed by drying with anhydrous sodium sulfate, filtration and distillation. Further purification by fractional distillation afforded 488.9 g (98% purity, 78.5% yield) of ethyl difluorochloroacetate with a boiling point of 94-96 °C.
References
[1] Patent: WO2005/3077, 2005, A1. Location in patent: Page 13
[2] Journal of the American Chemical Society, 1957, vol. 79, p. 4174,4177
Chlorodifluoroacetic acid ethyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 4000 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 12938 | 58 |
| Zjartschem | +86-571 87238903 | jocelynpan@zjarts.com | CHINA | 988 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from Chlorodifluoroacetic acid ethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | Chlorodifluoroacetic acid ethyl ester
383-62-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
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2024-06-26 | Chlorodifluoroacetic acid ethyl ester
383-62-0
|
US $1.00 / KG | 1KG | 99% | 20t | Shaanxi Dideu Medichem Co. Ltd | |
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2021-07-02 | Chlorodifluoroacetic acid ethyl ester
383-62-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Chlorodifluoroacetic acid ethyl ester
383-62-0
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Chlorodifluoroacetic acid ethyl ester
383-62-0
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Chlorodifluoroacetic acid ethyl ester
383-62-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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