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ChemicalBook >> CAS DataBase List >>4-Thiazolecarboxylic acid, 2-[4-[[4-(aminosulfonyl)-3-fluorophenyl]methyl]-5-(cyclopropylmethyl)-3-[3-[2-(5-methyl-2-thienyl)ethynyl]phenyl]-1H-pyrazol-1-yl]-

4-Thiazolecarboxylic acid, 2-[4-[[4-(aminosulfonyl)-3-fluorophenyl]methyl]-5-(cyclopropylmethyl)-3-[3-[2-(5-methyl-2-thienyl)ethynyl]phenyl]-1H-pyrazol-1-yl]-

4-Thiazolecarboxylic acid, 2-[4-[[4-(aminosulfonyl)-3-fluorophenyl]methyl]-5-(cyclopropylmethyl)-3-[3-[2-(5-methyl-2-thienyl)ethynyl]phenyl]-1H-pyrazol-1-yl]- Structure
4-Thiazolecarboxylic acid, 2-[4-[[4-(aminosulfonyl)-3-fluorophenyl]methyl]-5-(cyclopropylmethyl)-3-[3-[2-(5-methyl-2-thienyl)ethynyl]phenyl]-1H-pyrazol-1-yl]- structure
CAS No.
1964517-04-1
Chemical Name:
4-Thiazolecarboxylic acid, 2-[4-[[4-(aminosulfonyl)-3-fluorophenyl]methyl]-5-(cyclopropylmethyl)-3-[3-[2-(5-methyl-2-thienyl)ethynyl]phenyl]-1H-pyrazol-1-yl]-
Synonyms
NCATS-SM1441;4-Thiazolecarboxylic acid, 2-[4-[[4-(aminosulfonyl)-3-fluorophenyl]methyl]-5-(cyclopropylmethyl)-3-[3-[2-(5-methyl-2-thienyl)ethynyl]phenyl]-1H-pyrazol-1-yl]-
CBNumber:
CB88130312
Molecular Formula:
C31H25FN4O4S3
Molecular Weight:
632.75
MDL Number:
MOL File:
1964517-04-1.mol
Last updated:2025-04-18 09:52:56
Request For Quotation

4-Thiazolecarboxylic acid, 2-[4-[[4-(aminosulfonyl)-3-fluorophenyl]methyl]-5-(cyclopropylmethyl)-3-[3-[2-(5-methyl-2-thienyl)ethynyl]phenyl]-1H-pyrazol-1-yl]- Properties

Boiling point 885.8±75.0 °C(Predicted)
Density 1.49±0.1 g/cm3(Predicted)
pka 3.18±0.10(Predicted)

4-Thiazolecarboxylic acid, 2-[4-[[4-(aminosulfonyl)-3-fluorophenyl]methyl]-5-(cyclopropylmethyl)-3-[3-[2-(5-methyl-2-thienyl)ethynyl]phenyl]-1H-pyrazol-1-yl]- Chemical Properties,Uses,Production

Uses

NCATS-SM1441 (compound 52) is a lactate dehydrogenase (LDH) inhibitor (IC50=40 nM). By inhibiting the activity of LDH, NCATS-SM1441 is able to reduce the production of lactic acid in cancer cells, helping to slow or stop the proliferation of cancer cells. NCATS-SM1441 can be used to study cancer metabolism[1].

References

[1] Rai G, et al. Pyrazole-based lactate dehydrogenase inhibitors with optimized cell activity and pharmacokinetic properties[J]. Journal of medicinal chemistry, 2020, 63(19): 10984-11011. DOI:10.1021/acs.jmedchem.0c00916

4-Thiazolecarboxylic acid, 2-[4-[[4-(aminosulfonyl)-3-fluorophenyl]methyl]-5-(cyclopropylmethyl)-3-[3-[2-(5-methyl-2-thienyl)ethynyl]phenyl]-1H-pyrazol-1-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

4-Thiazolecarboxylic acid, 2-[4-[[4-(aminosulfonyl)-3-fluorophenyl]methyl]-5-(cyclopropylmethyl)-3-[3-[2-(5-methyl-2-thienyl)ethynyl]phenyl]-1H-pyrazol-1-yl]- Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3467 58
ATK CHEMICAL COMPANY LIMITED 021-51619050 13301662590 mandy@atkchemical.com China 9081 55
Shanghai Han-Xiang Chemical Co., Ltd. 15971444841 amber@biochempartner.com China 3061 58
Wuhan Topule +86-02787215551 +86-19945035818 2936752263@qq.com China 8081 58
JinOu Biomedical (Nanjing) Co., Ltd. 13000000000 jinoupharma@163.com China 11721 58
Hubei Kele Fine Chemical Co., Ltd 027-59101668 19945030958 2881924765@qq.com China 7997 58
Anqing YanZhi Pharma Discovery Co.,Ltd. 18055651951 2272561977@qq.com China 431 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
ATK CHEMICAL COMPANY LIMITED 55
Shanghai Han-Xiang Chemical Co., Ltd. 58
Wuhan Topule 58
JinOu Biomedical (Nanjing) Co., Ltd. 58
Hubei Kele Fine Chemical Co., Ltd 58
Anqing YanZhi Pharma Discovery Co.,Ltd. 58
4-Thiazolecarboxylic acid, 2-[4-[[4-(aminosulfonyl)-3-fluorophenyl]methyl]-5-(cyclopropylmethyl)-3-[3-[2-(5-methyl-2-thienyl)ethynyl]phenyl]-1H-pyrazol-1-yl]- NCATS-SM1441 1964517-04-1 C31H25FN4O4S3