Acetamide, N-(1,3-benzodioxol-5-ylmethyl)-N-methyl-
- CAS No.
- 168705-70-2
- Chemical Name:
- Acetamide, N-(1,3-benzodioxol-5-ylmethyl)-N-methyl-
- Synonyms
- N-[(1,3-Dioxaindan-5-yl)methyl]-N-methylacetamide;Acetamide, N-(1,3-benzodioxol-5-ylmethyl)-N-methyl-;N-(Benzo[d][1,3]dioxol-5-ylmethyl)-N-methylacetamide;Acetamide,inhibit,acnes,Propionibacterium,Endogenous Metabolite,hepatoprotective,Lipopolysaccharide,SY 640,SY640,Inhibitor,SY-640
- CBNumber:
- CB88134163
- Molecular Formula:
- C11H13NO3
- Molecular Weight:
- 207.23
- MDL Number:
- MFCD20143110
- MOL File:
- 168705-70-2.mol
Acetamide, N-(1,3-benzodioxol-5-ylmethyl)-N-methyl- Chemical Properties,Uses,Production
Uses
SY-640 is an Acetamide derivative and has potent hepatoprotective effect. SY-640 reduces Propionibacterium acnes and Lipopolysaccharide-induced liver injury in mice[1][2].
in vivo
SY-640 (Oral; 150 mg/kg; once daily for 7 days) significantly inhibits Propionibacterium acnes and Lipopolysaccharide-induced liver injury, but a single administration is without effect[1].
SY-640 (p.o.; 150 mg/kg; once daily for three days) significantly increases the liver microsomal cytochrome P-450 content and aminopyrine demethylase activity in mice. The hepatic microsomal aminopyrine demethylase activity is obviously inhibited two hours after oral administration of SY-640[2].
References
[1] Y Tanaka, et al. Hepatoprotective effect of SY-640, a novel acetamide derivative, on Propionibacterium acnes and lipopolysaccharide-induced liver injury in mice. Arch Int Pharmacodyn Ther. Mar-Apr 1995;329(2):319-30. PMID:8540770
[2] P F Li, et al. [Inhibitory effect of 2-(N-acetyl-methyl amino)-3',4'-methylenedioxyacetyl-aminophene(SY-640) on covalent binding of carcinogenic benzo(a)pyrene with mouse hepatocyte nuclear DNA]. Yao Xue Xue Bao. 1997 Sep;32(9):663-8. PMID:11596290
Acetamide, N-(1,3-benzodioxol-5-ylmethyl)-N-methyl- Preparation Products And Raw materials
Raw materials
Preparation Products
Acetamide, N-(1,3-benzodioxol-5-ylmethyl)-N-methyl- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29770 | 58 |
| Hubei wei shi reagent group ltd., company | 027-59102966 18717199209 | 2853877583@qq.com | China | 2539 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62320 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2380 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5840 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Hubei Chuchang Chemical Co., Ltd | 18 15623560702 | info@chuchangbiotech.com | China | 162 | 58 |
