Suplatast tosilate
- CAS No.
- 94055-76-2
- Chemical Name:
- Suplatast tosilate
- Synonyms
- Suplatast tosylate;IPD-1151T;Suplatast;SUPLATAST TOSILATE;Suplatast Tosylate >Methotrexate Impurity 47;Suplatast tosilate USP/EP/BP;Suplatast Tosylate (IPD 1151T);TIANFU CHEM--Suplatast tosilate;N,N-dimethyl-2-propyl-1-pentanamine
- CBNumber:
- CB8837187
- Molecular Formula:
- C23H33NO7S2
- Molecular Weight:
- 499.64062
- MDL Number:
- MFCD00867604
- MOL File:
- 94055-76-2.mol
- MSDS File:
- SDS
| Melting point | 84-87°C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO: >20mg/mL |
| form | powder |
| color | white to off-white |
| Merck | 14,9003 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| InChIKey | RYVJQEZJUFRANT-UHFFFAOYSA-N |
| SMILES | C1(NC(=O)CC[S+](C)C)=CC=C(OCC(O)COCC)C=C1.C1(S([O-])(=O)=O)=CC=C(C)C=C1 |
| CAS DataBase Reference | 94055-76-2(CAS DataBase Reference) |
| FDA UNII | C9J89787U1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
| RTECS | WR7906000 |
| HS Code | 2930.90.2900 |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 81, 96, 96, 93 i.v.; in mice, rats (g/kg): >12.5, >10 orally (Yamashita) |
Suplatast tosilate price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S4701 | Suplatast tosylate ≥98% (HPLC) | 94055-76-2 | 50mg | $303 | 2025-07-31 | Buy |
| Sigma-Aldrich | S4701 | Suplatast tosylate ≥98% (HPLC) | 94055-76-2 | 10mg | $77.6 | 2022-05-15 | Buy |
| TCI Chemical | S0875 | Suplatast Tosylate >98.0%(HPLC)(N) | 94055-76-2 | 100mg | $46 | 2025-07-31 | Buy |
| TCI Chemical | S0875 | Suplatast Tosylate >98.0%(HPLC)(N) | 94055-76-2 | 1g | $273 | 2025-07-31 | Buy |
| Cayman Chemical | 30316 | Suplatast (tosylate) | 94055-76-2 | 50mg | $68 | 2024-03-01 | Buy |
Suplatast tosilate Chemical Properties,Uses,Production
Description
Suplatast tosylate is a unique dimethylsulfonium salt marketed in Japan for the treatment of bronchial asthma, atopic dermatitis and allergic rhinitis. Suplatast tosylate is a potent inhibitor of IgE synthesis without suppressing IgM and IgG. The mechanism of action for suplatast tosylate is thought to be via the inhibition of interleukin-4 and interleukin-6 production by T-cells at the gene level. In allergic patients, suplatast tosylate markedly improved clinical symptoms which correlated with a significant decrease in serum IgE antibody levels.
Description
Suplatast is an antiallergic agent. It inhibits IL-4 and IL-5 production in conalbumin-stimulated D10.G4.1 murine T helper 2 (Th2) cells in a concentration-dependent manner. Suplatast (100 mg/kg) inhibits ovalbumin-induced increases in eosinophil and total cell numbers, as well as IL-4, IL-5, and IL-13, but not IFN-γ, levels in bronchoalveolar lavage fluid (BALF) in an ovalbumin-sensitized mouse model of asthma. It also inhibits ovalbumin-induced increases in ovalbumin-specific IgE in serum and bronchial hyperresponsiveness to methacholine in the ovalbumin-sensitized mouse model of asthma.
Originator
Taiho (Japan)
Uses
Suplatast Tosylate is an antiallergic drug. Suplatast Tosylate inhibits antigen-induced histamine release from mast cells as well as IgE antibody formation. Suplatast Tosylate suppresses interleukin (IL)-4 release from T cells, however in human peripheral basophils, Suplatast Tosylate inhibited the antigen-induced release of IL-13 but not IL-4.
Uses
Suplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.
brand name
IPD
Biological Activity
Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN- γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.
References
[1] Suppressive effects of anti-allergic agent suplatast tosilate (IPD-1151T) on the expression of co-stimulatory molecules on mouse splenocytes in vivo
[2] LI-WEN HSU . The effects of suplatast tosilate (IPD-1151T) on innate immunity and antigen-presenting cells[J]. Transplant immunology, 2007, 18 2: Pages 108-114. DOI:10.1016/j.trim.2007.05.008
[3] MAKOTO FURONAKA. Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice.[J]. Journal of Pharmacology and Experimental Therapeutics, 2009, 328 1: 55-61. DOI:10.1124/jpet.108.141721
[4] DEBAPRIYA BHATTACHARYA. Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances Bacillus Calmette-Guerin vaccine efficacy against tuberculosis.[J]. The Journal of Biological Chemistry, 2014, 289 48: 33404-33411. DOI:10.1074/jbc.m114.600452
[5] MARIKO WADA . Effect of Suplatast Tosilate on Antileukotriene Non-Responders with Mild-to-Moderate Persistent Asthma[J]. Allergology International, 2009, 58 3: Pages 389-393. DOI:10.2332/allergolint.08-oa-0068
Suplatast tosilate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12271 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8367 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 | sales8@hbganmiao.com | China | 300 | 58 |
| Shaanxi Xianhe Biotech Co., Ltd | +86-17709210191; +8617709210191 | Jerry@xhobio.com | China | 883 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14360 | 58 |
View Lastest Price from Suplatast tosilate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-24 | Suplatast tosilate
94055-76-2
|
US $65.40-800.00 / g | 1g | 0.98 | 10kg | Shanghai UCHEM Inc. | |
 |
2025-09-24 | Suplatast (Tosilate)
94055-76-2
|
US $63.00-39.00 / mg | 99.65% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-09-24 | Suplatast (Tosilate)
94055-76-2
|
US $63.00-39.00 / mg | 99.65% | 10g | TargetMol Chemicals Inc. |
-
- Suplatast tosilate
94055-76-2
- US $65.40-800.00 / g
- 0.98
- Shanghai UCHEM Inc.
-
- Suplatast (Tosilate)
94055-76-2
- US $63.00-39.00 / mg
- 99.65%
- TargetMol Chemicals Inc.
-
- Suplatast (Tosilate)
94055-76-2
- US $63.00-39.00 / mg
- 99.65%
- TargetMol Chemicals Inc.
