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Tetramethylene sulfoxide

CAS No.
1600-44-8
Chemical Name:
Tetramethylene sulfoxide
Synonyms
TETRAHYDROTHIOPHENE 1-OXIDE;TETRAHYDROTHIOPHENE OXIDE;Thiophane oxide;thiophane1-oxide;Thiolane 1-oxide;Thiophane 1-oxide;thiophanemonoxide;1λ?-thiolan-1-one;Thiophane monoxide;Thiophene sulfoxide
CBNumber:
CB8853165
Molecular Formula:
C4H8OS
Molecular Weight:
104.17
MDL Number:
MFCD00005477
MOL File:
1600-44-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-25 20:17:46

Tetramethylene sulfoxide Properties

Boiling point 235-237 °C(lit.)
Density 1.158 g/mL at 25 °C(lit.)
refractive index n20/D 1.52(lit.)
Flash point >230 °F
storage temp. Storage temp. 2-8°C
form Liquid
color Clear colorless to yellow
Water Solubility Fully miscible in water.
BRN 105274
Dielectric constant 5.6(25℃)
InChI 1S/C4H8OS/c5-6-3-1-2-4-6/h1-4H2
InChIKey ISXOBTBCNRIIQO-UHFFFAOYSA-N
SMILES O=S1CCCC1
CAS DataBase Reference 1600-44-8(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII FL7PF5FLM2
EPA Substance Registry System Thiophene, tetrahydro-, 1-oxide (1600-44-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
PPE Eyeshields, Gloves
Safety Statements  24/25
WGK Germany  3
RTECS  XN0830000
TSCA  TSCA listed
HS Code  29041000
Storage Class 10 - Combustible liquids
Toxicity mouse,LD50,intraperitoneal,3500mg/kg (3500mg/kg),International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. Vol. 3, Pg. 41, 1961.
NFPA 704
1
0 0

Tetramethylene sulfoxide price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T22403 Tetrahydrothiophene 1-oxide 96% 1600-44-8 25g $119 2026-04-30 Buy
TCI Chemical T0146 Tetramethylene Sulfoxide >95.0%(GC) 1600-44-8 25g $68 2026-04-30 Buy
TCI Chemical T0146 Tetramethylene Sulfoxide >95.0%(GC) 1600-44-8 500g $597 2026-04-30 Buy
Apolloscientific OR916306 Tetramethylene sulfoxide >99% 1600-44-8 1g $21 2026-06-04 Buy
Apolloscientific OR916306 Tetramethylene sulfoxide >99% 1600-44-8 5g $24 2026-06-04 Buy
Product number Packaging Price Buy
T22403 25g $119 Buy
T0146 25g $68 Buy
T0146 500g $597 Buy
OR916306 1g $21 Buy
OR916306 5g $24 Buy

Tetramethylene sulfoxide Chemical Properties, Uses, Production

Chemical Properties

clear colorless to yellow liquid

Uses

In a comparative study of aromatic fluorodenitration with Potassium fluoride, in several dipolar aprotic solvents, a much faster reaction rate was observed with DMSO or tetramethylene sulfoxide than with the more commonly used Sulfolane.

Definition

ChEBI: Tetrahydrothiophene 1-oxide is a member of tetrahydrothiophenes.

Synthesis Reference(s)

Journal of the American Chemical Society, 63, p. 2939, 1941 DOI: 10.1021/ja01856a021
The Journal of Organic Chemistry, 50, p. 1787, 1985 DOI: 10.1021/jo00210a055
Synthetic Communications, 24, p. 2393, 1994 DOI: 10.1080/00397919408010545

Purification Methods

Shake the oxide with BaO for 4 days, then distil it from CaH2 under reduced pressure. [Beilstein 17 III/IV 36, 17/1 V 38.]

Tetramethylene sulfoxide Preparation Products And Raw materials

Raw materials

Preparation Products

Global Suppliers ( 161)
Supplier Tel Email Country ProdList Advantage
Shanghai Xingui Biotechnology Co., Ltd. 15121041756 xingui2022@126.com China 9978 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 45000 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57

View Latest Price from Tetramethylene sulfoxide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tetramethylene sulfoxide pictures 2026-05-15 Tetramethylene sulfoxide
1600-44-8
$1.50 1g 99.0% Min 100 Tons Shaanxi Didu New Materials Co. Ltd
TetraMethylene sulfoxide, 98+% 5GR Tetrahydrothiophene 1-oxide 96% TETRAMETHYLENE SULFOXIDE TETRAMETHYLENE SULPHOXIDE tetrahydro-thiophen1-oxide Tetrametylene sulfoxide Thiolane 1-oxide Thiophane 1-oxide Thiophane monoxide Thiophane oxide thiophane1-oxide thiophanemonoxide Thiophene sulfoxide Thiophene-1-oxide, tetrahydro- TETRAHYDROTHIOPHENE-S-OXIDE Tetramethylene sulfoxide, 98+% Thiophene, tetrahydro-, 1-oxide Tetramethylene Sulfoxide > 1λ?-thiolan-1-one Tetramethylene Sulfoxid Tetramethylene sulfoxide (TMSO) TETRAHYDROTHIOPHENE 1-OXIDE TETRAHYDROTHIOPHENE OXIDE 1600-44-8 Thiophenes Heterocyclic Building Blocks Building Blocks