1-(4-hydroxy-3-methoxyphenyl)decan-5-one
- CAS No.
- 27113-22-0
- Chemical Name:
- 1-(4-hydroxy-3-methoxyphenyl)decan-5-one
- Synonyms
- 6-paradol;PARADOL;[6]-Gingerone;1-(4-Hydroxy-3-methoxyphenyl)-3-decanone;5-Paradol;6-Paradol 98%;3-Decanone, 1-(4-hydroxy-3-methoxyphenyl)-;Parado;Ccris 8519;Brn 1984119
- CBNumber:
- CB8927406
- Molecular Formula:
- C17H26O3
- Molecular Weight:
- 278.39
- MDL Number:
- MFCD01736103
- MOL File:
- 27113-22-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 406.4±30.0 °C(Predicted) |
|---|---|
| Density | 1.0690 g/cm3 |
| refractive index | 1.5232 (589.3 nm 20℃) |
| FEMA | 4665 | 1-(4-HYDROXY-3-METHOXYPHENYL)DECAN-3-ONE |
| FLAVIS Number | 07.234 | 1-(4-Hydroxy-3-methoxyphenyl)-3-decanone |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 10.02±0.20(Predicted) |
| color | White to Brown |
| Odor | spicy herbal |
| Odor Type | spicy |
| JECFA Number | 2021 |
| Major Application |
food and beverages pharmaceutical |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChI | InChI=1S/C17H26O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h10,12-13,19H,3-9,11H2,1-2H3 |
| InChIKey | CZNLTCTYLMYLHL-UHFFFAOYSA-N |
| SMILES | C(C1=CC=C(O)C(OC)=C1)CC(=O)CCCCCCC |
| LogP | 3.83 |
| Substances Added to Food (formerly EAFUS) | 1-(4-HYDROXY-3-METHOXYPHENYL)DECAN-3-ONE |
| EWG's Food Scores | 1 |
| FDA UNII | BO24ID7E9U |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
| WGK Germany | WGK 2 |
| Storage Class | 11 - Combustible Solids |
1-(4-hydroxy-3-methoxyphenyl)decan-5-one price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | P2982 | Paradol | 27113-22-0 | 1G | $213 | 2026-04-30 | Buy |
| Cayman Chemical | 27554 | 6-Paradol ≥98% | 27113-22-0 | 25mg | $107 | 2026-04-30 | Buy |
| Cayman Chemical | 27554 | 6-Paradol ≥98% | 27113-22-0 | 50mg | $203 | 2026-04-30 | Buy |
| Cayman Chemical | 27554 | 6-Paradol ≥98% | 27113-22-0 | 100mg | $381 | 2026-04-30 | Buy |
| Cayman Chemical | 27554 | 6-Paradol ≥98% | 27113-22-0 | 250mg | $845 | 2026-04-30 | Buy |
1-(4-hydroxy-3-methoxyphenyl)decan-5-one Chemical Properties, Uses, Production
Chemical Properties
6-Gingerol (6-gingerol) is a member of the curcumin family and is one of the main active components of ginger. It is a compound with a pungent flavor, and its chemical structure is similar to that of capsaicin, but its spiciness is only one hundredth, or even one thousandth, of that of capsaicin, and it has very little irritation.6-gingerol contains a phenolic group and an alicyclic ring in its structure, which makes it polar and hydrophobic, and thus affects its biological activity and pharmacological effects.
Uses
Paradol is a Gingerol related compound from ginger with antioxidant activity and cancer preventive properties.
Definition
ChEBI: [6]-Paradol is a member of phenols, a ketone and a monomethoxybenzene.
Synthesis
53172-10-4
27113-22-0
Under nitrogen protection, 16 g of sodium metal, 3.5 g of anhydrous sodium acetate and 110 g of tetrahydrofuran were added to the reaction flask and stirred at room temperature. A solution consisting of 50 g of olefinic intermediate and 200 g of ethanol was slowly added dropwise and the dropwise process was completed in about 2 hours. The reaction was then heated and refluxed, and the progress of the reaction was monitored by thin layer chromatography (unfolding agent ratio petroleum ether: dichloroethane = 3:2). After the complete disappearance of the raw material, the reaction was continued for 3.5 hours. The reaction was stopped, 10 g of activated carbon was added and refluxing was continued for 0.5 hours. The reaction mixture was filtered and concentrated under reduced pressure to remove the solvent. The residue was washed with water, layered and dehydrated to give a light yellow oily product. The purity of the product was 98% and the yield was 94%.
in vivo
Administration of Paradol (6-paradol) (10 mg/kg) clearly reduces the number of Iba1-positive cells 1 and 3 days after the challenge. Moreover, Paradol dramatically reduces the number of Iba1-postive cells in periischemic regions even after 3 days following M/R challenge[3]. Paradol (6-paradol) exhibits the strongest anti-inflammatory effect of several paradol compounds in lipopolysaccharide-stimulated BV2 microglia derived from a mouse brain, including 2-, 4-, 6-, 8-, and 10-paradol. Furthermore, Paradol shows the strongest pungency of all of the known paradol analogues. Paradol also shows the highest contact time at the antiobesity site of action on the basis of the results shown for the absorption of the metabolites in this study[4].
target
Antifection
IC 50
COX-2
References
[1] Patent: CN106866393, 2017, A. Location in patent: Paragraph 0045; 0046; 0047; 0048
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972, p. 3001 - 3006
1-(4-hydroxy-3-methoxyphenyl)decan-5-one Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Myland Nutraceuticals Inc. | 13771927830 | james@mylandpharm.com | China | 58 | 55 |
| Jinan Kewei Biotechnology Co., LTD | 15315592897 | xmxingbjlg@163.com | China | 201 | 58 |
| Jiangshan Chuangsheng Bioengineering Co., Ltd | 13775204409 13775204409 | 164866523@qq.com | China | 208 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
View Latest Price from 1-(4-hydroxy-3-methoxyphenyl)decan-5-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | 1-(4-hydroxy-3-methoxyphenyl)decan-5-one
27113-22-0
|
100G | 50%min | 30KG/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-15 | 6-paradol; 1-(4-hydroxy-3-methoxyphenyl)decan-5-one
27113-22-0
|
1kg | 99% | 20t | Jinan Jianfeng Chemical Co., Ltd | ||
 |
2026-09-01 | Paradol ;6-Paradol
27113-22-0
|
1kg | 99% | 10000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd |
-
- 1-(4-hydroxy-3-methoxyphenyl)decan-5-one
27113-22-0
- $0.00
- 50%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 6-paradol; 1-(4-hydroxy-3-methoxyphenyl)decan-5-one
27113-22-0
- 99%
- Jinan Jianfeng Chemical Co., Ltd
-
- Paradol ;6-Paradol
27113-22-0
- $0.00
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
