ChemicalBook >> CAS DataBase List >>3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester

3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester

3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester structure

CAS No.: 77087-60-6

Chemical Name:: 3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester

Synonyms: methyl (S)-2-amino-3-((tert-butoxycarbonyl)amino)propanoate;H-Dap(Boc)-OMe;H-L-Dap(Boc)-OMe;(S)-methyl 2-amino-3-N-Boc-propanoate;tert-butyl (S)-2-(methoxycarbonyl)-2-aminoethylcarbamate;(R)-ethyl 2-aMino-3-((tert-butoxycarbonyl)aMino)propanoate;(S)-Methyl 2-aMino-3-((tert-butoxycarbonyl)aMino)propanoate;3-[[(1,1-DiMethylethoxy)carbonyl]aMino]-L-alanine Ethyl Ester;3-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-L-ALANINE METHYL ESTER;3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl est...

CBNumber:: CB8947482

Molecular Formula:: C9H18N2O4

Molecular Weight:: 218.25

MDL Number:: MFCD04039602

MOL File:: 77087-60-6.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:51

Product description	Number	Pack Size	Price
Methyl3-[t-Butyloxycarbonyl)amino]-L-alanine	M294425	100mg	$100
(S)-Methyl 2-amino-3-((tert-butoxycarbonyl)amino)propanoate 96+% ee	AS34013	1g	$143
(S)-Methyl 2-amino-3-((tert-butoxycarbonyl)-amino)propanoate 95+%	076568	5g	$240
(S)-Methyl 2-amino-3-((tert-butoxycarbonyl)amino)propanoate 96+% ee	AS34013	5G	$410
H-Dap(Boc)-OMe	X7002	5g	$600
More product size

Request For Quotation

3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester Properties

Boiling point	325.7±32.0 °C(Predicted)
Density	1.107±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	soluble in Dichloromethane, Ether, Ethyl Acetate, Hexane
pka	11.95±0.46(Predicted)
form	Oil
color	Viscous Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	M294425	Methyl3-[t-Butyloxycarbonyl)amino]-L-alanine	77087-60-6	100mg	$100	2021-12-16	Buy
Activate Scientific	AS34013	(S)-Methyl 2-amino-3-((tert-butoxycarbonyl)amino)propanoate 96+% ee	77087-60-6	1g	$143	2021-12-16	Buy
Matrix Scientific	076568	(S)-Methyl 2-amino-3-((tert-butoxycarbonyl)-amino)propanoate 95+%	77087-60-6	5g	$240	2021-12-16	Buy
Activate Scientific	AS34013	(S)-Methyl 2-amino-3-((tert-butoxycarbonyl)amino)propanoate 96+% ee	77087-60-6	5G	$410	2021-12-16	Buy
AK Scientific	X7002	H-Dap(Boc)-OMe	77087-60-6	5g	$600	2021-12-16	Buy

Product number	Packaging	Price	Buy
M294425	100mg	$100	Buy
AS34013	1g	$143	Buy
076568	5g	$240	Buy
AS34013	5G	$410	Buy
X7002	5g	$600	Buy

3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester Chemical Properties,Uses,Production

Chemical Properties

Viscous Yellow Oil

Uses

Methyl 3-[t-Butyloxycarbonyl)amino]-L-alanine (cas# 77087-60-6) is a compound useful in organic synthesis.

Synthesis

24424-99-5

Methyl 2,3-diaMinopropanoate dihydrochloride

6059-44-5

3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester

77087-60-6

General procedure for the synthesis of methyl (S)-2-amino-3-((tert-butoxycarbonyl)amino)propionate from di-tert-butyl dicarbonate and methyl 2,3-diaminopropionate dihydrochloride: 10.0 g (0.053 mol) of methyl 2,3-diaminopropionate dihydrochloride was suspended in 1 L of dichloromethane, and cooled to -78 °C under argon protection. To this cold suspension triethylamine (30 ml, 0.20 mol) was added slowly and dropwise to obtain a clarified solution. Di-tert-butyl dicarbonate (11.6 g, 0.054 mol) was dissolved in 100 mL of dichloromethane and added dropwise to the above mixture. After dropwise addition, the reaction mixture was transferred to an ice bath and stirring was continued for 2 hours. After completion of the reaction, the mixture was transferred to a partition funnel and extracted with 2 x 50 mL of 10% Na2SO4 solution. The aqueous layer was washed with 3 x 10 mL dichloromethane and then the pH was adjusted to 10 with saturated NaHCO3 solution and 3N NaOH solution and extracted with 10 x 100 mL dichloromethane. The organic layers were combined, dried with anhydrous MgSO4, filtered and concentrated to give 4.9 g of light yellow oil. Purification by silica gel column chromatography with 2.5% methanol/ethyl acetate as eluent gave 4.32 g of the target product in 53% yield. High resolution mass spectrometry (HRMS): m/z 219.1324 (M + H+), 241.11436 (M + Na+). 1H NMR (300 MHz, CDCl3): δ [ppm] = 5.11 (s, 1H), 3.78-3.69 (s, 3H), 3.60-3.46 (m, 2H), 3.31-3.15 (m, 1H), 1.64 (m, 2H), 3.31-3.15 (m, 1H). 1H), 1.64 (s, 2H), 1.42 (s, 9H). 13C NMR (75 MHz, CDCl3): δ [ppm] = 174.46, 155.94, 79.48, 54.36, 52.26, 44.16, 28.30.

References

[1] Patent: WO2014/122228, 2014, A1. Location in patent: Page/Page column 23; 24
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 23, p. 9971 - 9982

3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate Methyl 2,3-diaMinopropanoate dihydrochloride Triethylamine Dichloromethane

Preparation Products

3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester Suppliers

Global( 76)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29796	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20284	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24727	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Dideu Industries Group Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Nextpeptide Inc	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from 3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-09	3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester 77087-60-6	US $1.00 / KG	1KG	99.0%	100kg	Career Henan Chemical Co

3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester
77087-60-6
US $1.00 / KG
99.0%
Career Henan Chemical Co

77087-60-6(3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester)Related Search:

Methylparaben β-Alanine Methyl 2-bromopropionate Methanol Methyl propionate

Methyl acrylate Methyl salicylate Glucosamine PYRAZOPHOS Sulfamic acid

Methyl 2,3-dichloropropionate Acetaminophen DL-Alanine Methyl anthranilate L-Alanine

EC 2.6.1.2 Tribenuron methyl Methyl levulinate

1of4

methyl (L)-2-amino-3-((tert-butoxycarbonyl)amino)propanoate hydrochloride methyl (S)-2-amino-3-((tert-butoxycarbonyl)amino)propanoate H-Dap(Boc)-OMe 3-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-L-ALANINE METHYL ESTER (S)-methyl 2-amino-3-N-Boc-propanoate H-L-Dap(Boc)-OMe (2S)-2-AMino-3-[(tert-butoxycarbonyl)aMino]propionic Acid Methyl Ester 3-[[(1,1-DiMethylethoxy)carbonyl]aMino]-L-alanine Ethyl Ester (S)-Methyl 2-aMino-3-((tert-butoxycarbonyl)aMino)propanoate (R)-ethyl 2-aMino-3-((tert-butoxycarbonyl)aMino)propanoate tert-butyl (S)-2-(methoxycarbonyl)-2-aminoethylcarbamate L-Alanine, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester 3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester USP/EP/BP 3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl est... 77087-60-6 Amino Acids & Derivatives