3,3-Difluorocyclobutanecarboxylic acid
- CAS No.
- 107496-54-8
- Chemical Name:
- 3,3-Difluorocyclobutanecarboxylic acid
- Synonyms
- 3,3-Difluoro-cyclobutanec...;3-Difluorocyclobutanecarboxylic acid;3,3-Difluorocyclobutanecarboxylic acid;Cyclobutanecarboxylic acid, 3,3-difluoro-;3,3-Difluorocyclobutanecarboxylic acid 98%;3,3-Difluorocyclobutanecarboxylic Acid(WXFC0148);TIANFU-CHEM 107496-54-8 3,3-Difluorocyclobutanecarboxylic acid
- CBNumber:
- CB8966436
- Molecular Formula:
- C5H6F2O2
- Molecular Weight:
- 136.1
- MDL Number:
- MFCD08705857
- MOL File:
- 107496-54-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3,3-Difluoro-cyclobutanecarboxylic acid Aldrich | MNO000127 | 1g | $304 |
| 3,3-Difluorocyclobutanecarboxylic Acid >98.0%(GC)(T) | D5225 | 200mg | $21 |
| 3,3-Difluorocyclobutanecarboxylic Acid >98.0%(GC)(T) | D5225 | 1g | $60 |
| 3,3-Difluorocyclobutanecarboxylic Acid | D447593 | 250mg | $55 |
| 3,3-Difluorocyclobutane-1-carboxylic acid | FD104436 | 250mg | $250 |
| More product size | |||
| Melting point | 51.0 to 55.0 °C |
|---|---|
| Boiling point | 205 °C |
| Density | 1.37 |
| Flash point | 78 °C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 3.63±0.40(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| InChI | InChI=1S/C5H6F2O2/c6-5(7)1-3(2-5)4(8)9/h3H,1-2H2,(H,8,9) |
| InChIKey | PLRCVBKYFLWAAT-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)CC(F)(F)C1 |
| UNSPSC Code | 12352106 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| RIDADR | UN 3261 8/PG III | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2916200090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3,3-Difluorocyclobutanecarboxylic acid price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | MNO000127 | 3,3-Difluoro-cyclobutanecarboxylic acid Aldrich | 107496-54-8 | 1g | $304 | 2026-03-19 | Buy |
| TCI Chemical | D5225 | 3,3-Difluorocyclobutanecarboxylic Acid >98.0%(GC)(T) | 107496-54-8 | 200mg | $21 | 2026-03-19 | Buy |
| TCI Chemical | D5225 | 3,3-Difluorocyclobutanecarboxylic Acid >98.0%(GC)(T) | 107496-54-8 | 1g | $60 | 2026-03-19 | Buy |
| TRC | D447593 | 3,3-Difluorocyclobutanecarboxylic Acid | 107496-54-8 | 250mg | $55 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD104436 | 3,3-Difluorocyclobutane-1-carboxylic acid | 107496-54-8 | 250mg | $250 | 2021-12-16 | Buy |
3,3-Difluorocyclobutanecarboxylic acid Chemical Properties,Uses,Production
Uses
3,3-Difluorocyclobutane carboxylic acid is used as an organic and pharmaceutical intermediate.
Synthesis Reference(s)
Synthetic Communications, 35, p. 657, 2005 DOI: 10.1081/SCC-200050350
Synthesis
935273-86-2
107496-54-8
General procedure for the synthesis of 3,3-difluorocyclobutanecarboxylic acid from benzyl ester of 3,3-difluorocyclobutanecarboxylate: benzyl ester of 3,3-difluorocyclobutanecarboxylic acid (0.84 g, 3.72 mmol) was dissolved in ethanol (40 mL), and about 0.02 g of palladium/activated carbon catalyst was added. The reaction mixture was stirred at room temperature for 12 hours in a hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad. The filtrate was concentrated and dried under vacuum to afford the target product 3,3-difluorocyclobutanecarboxylic acid (0.46 g, 90% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.16-2.55 (m, 5H).
References
[1] Patent: WO2013/107405, 2013, A1. Location in patent: Page/Page column 42
[2] Patent: US2015/87600, 2015, A1. Location in patent: Page/Page column
[3] Patent: EP3290418, 2018, A1. Location in patent: Paragraph 0172; 0181
[4] Patent: US9273058, 2016, B2. Location in patent: Page/Page column 337; 338
[5] Patent: WO2007/47625, 2007, A2. Location in patent: Page/Page column 24
3,3-Difluorocyclobutanecarboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29822 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| BTC Nantong Pharmaceuticals Technology Co.,Ltd | +86-0513-81283365 | Info@btcpharm.com | China | 251 | 58 |
| Changzhou Carman Chemical Co., Ltd. | 15061933924 | CHINA | 514 | 58 | |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
View Lastest Price from 3,3-Difluorocyclobutanecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | 3,3-Difluorocyclobutanecarboxylic acid
107496-54-8
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
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2024-02-26 | 3,3-Difluorocyclobutanecarboxylic acid
107496-54-8
|
US $0.00-0.00 / kg | 1kg | 98% | Kgs | BTC Nantong Pharmaceuticals Technology Co.,Ltd | |
 |
2021-07-02 | 3,3-Difluorocyclobutanecarboxylic acid
107496-54-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 3,3-Difluorocyclobutanecarboxylic acid
107496-54-8
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3,3-Difluorocyclobutanecarboxylic acid
107496-54-8
- US $0.00-0.00 / kg
- 98%
- BTC Nantong Pharmaceuticals Technology Co.,Ltd
-
- 3,3-Difluorocyclobutanecarboxylic acid
107496-54-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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