LY 294002
- CAS No.
- 934389-88-5
- Chemical Name:
- LY 294002
- Synonyms
- LY 294002, HYDROCHLORIDE SALT;LY-294,002 hydrochloride【L9908】;LY 294002, Hydrochloride Salt, >99%;LY-294,002 hydrochloride, ≥98% (HPLC);LY-294002 hydrochloride, 10 mM in DMSO;2-morpholino-8-phenyl-4H-chromen-4-one hydrochloride;2-morpholin-4-yl-8-phenylchromen-4-one,hydrochloride;LY-294,002 hydrochloride, 98%, selective inhibitor of PI 3-kinase
- CBNumber:
- CB8972820
- Molecular Formula:
- C19H18ClNO3
- Molecular Weight:
- 343.80412
- MDL Number:
- MFCD01530034
- MOL File:
- 934389-88-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| LY-294,002 hydrochloride solid, ≥98% (HPLC) | L9908 | 1mg | $76.2 |
| LY-294,002 hydrochloride solid, ≥98% (HPLC) | L9908 | 5mg | $186.2 |
| LY-294,002 hydrochloride | L503113 | 100mg | $395 |
| LY 294002 HYDROCHLORIDE 95.00% | KIN0002442 | 5MG | $500.96 |
| LY-294,002 hydrochloride | 0286AQ | 5mg | $240 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| WGK Germany | 3 |
| HS Code | 29349990 |
LY 294002 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L9908 | LY-294,002 hydrochloride solid, ≥98% (HPLC) | 934389-88-5 | 1mg | $76.2 | 2025-07-31 | Buy |
| Sigma-Aldrich | L9908 | LY-294,002 hydrochloride solid, ≥98% (HPLC) | 934389-88-5 | 5mg | $186.2 | 2025-07-31 | Buy |
| TRC | L503113 | LY-294,002 hydrochloride | 934389-88-5 | 100mg | $395 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0002442 | LY 294002 HYDROCHLORIDE 95.00% | 934389-88-5 | 5MG | $500.96 | 2021-12-16 | Buy |
| AK Scientific | 0286AQ | LY-294,002 hydrochloride | 934389-88-5 | 5mg | $240 | 2021-12-16 | Buy |
LY 294002 Chemical Properties,Uses,Production
Uses
LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).
General Description
LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.
Biological Activity
Specific cell permeable phosphatidylinositol 3-kinase inhibitor.
in vivo
LY294002 hydrochloride (10, 25, 50, 75 mg/kg; i.p.; twice weekly; for 4 weeks) significantly reduces mean NPC tumor burden in a dose-dependent manner. LY294002 (10, 25 mg/kg) is less effective in decreasing tumor burden[4].
LY294002 hydrochloride (1.2 mg/kg per day; i.p.; for 14 days) prevents Leptin (60 ug/kg)-induced adverse effects on spermatozoa in Sprague-Dawley rats[5].
| Animal Model: | Athymic nude mice (6-8 weeks) with CNE-2Z xenograft[4] |
| Dosage: | 10 mg/kg, 25 mg/kg, 50 mg/kg, and 75 mg/kg |
| Administration: | IP; twice weekly, for 4 weeks |
| Result: | Mean Nasopharyngeal carcinoma (NPC) tumor burden was remarkably decreased in a dose-dependent manner. |
IC 50
CK2: 0.098 μM (IC50); CK2α2: 3.869 μM (IC50)
storage
Room temperature
LY 294002 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2251 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39032 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 14831 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4747 | 58 |
View Lastest Price from LY 294002 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-17 | LY-294002 hydrochloride
934389-88-5
|
US $42.00-94.00 / mg | 99.95% | 10g | TargetMol Chemicals Inc. |
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- LY-294002 hydrochloride
934389-88-5
- US $42.00-94.00 / mg
- 99.95%
- TargetMol Chemicals Inc.
