NR-160
- CAS No.
- 2484895-50-1
- Chemical Name:
- NR-160
- Synonyms
- NR-160;NR 160,NR160;N-[[4-[(hydroxyamino)carbonyl]phenyl]methyl]-N-[[1-(phenylmethyl)-1H-tetrazol-5-yl]methyl]-2-(trifluoromethyl)-benzamide;Benzamide, N-[[4-[(hydroxyamino)carbonyl]phenyl]methyl]-N-[[1-(phenylmethyl)-1H-tetrazol-5-yl]methyl]-2-(trifluoromethyl)-
- CBNumber:
- CB89739309
- Molecular Formula:
- C25H21F3N6O3
- Molecular Weight:
- 510.47
- MDL Number:
- MOL File:
- 2484895-50-1.mol
NR-160 Chemical Properties,Uses,Production
Uses
NR160 is a selective HDAC6 inhibitor with an IC50 value of 30 nM. NR160 shows low cytotoxicity against leukemia cell line. NR160 augments the apoptosis induction of Bortezomib.html" class="link-product" target="_blank">Bortezomib (HY-10227) (proteasome inhibitor), Epirubicin.html" class="link-product" target="_blank">Epirubicin (HY-13624) and Daunorubicin.html" class="link-product" target="_blank">Daunorubicin (HY-13062A) significantly[1][2].
Biological Activity
NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 0.03 μM).1 It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 μM). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.
IC 50
HDAC6: 30 nM (IC50)
References
1.Re?ing, N., S?nnichsen, M., Osko, J.D., et al.Multicomponent synthesis, binding mode, and structure-activity relationship of selective histone deacetylase 6 (HDAC6) inhibitors with bifurcated capping groupsJ. Med. Chem.63(18)10339-10351(2020)
NR-160 Preparation Products And Raw materials
Raw materials
Preparation Products
NR-160 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32277 | 58 |
| ChemeGen 中国 | 18818260767 | 2625930290@qq.com | China | 6973 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1248 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 20568 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 27736 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 292394 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 233051 | 58 |
