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ChemicalBook >> CAS DataBase List >>2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene

2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene

2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene Structure
2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene structure
CAS No.
172900-69-5
Chemical Name:
2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene
Synonyms
-1-methoxybenzene;2-(3-Methoxypropoxy);2-(3-Methoxypropoxy)-4-((R)-2-(broMoMethyl)-3;2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1...;4-(5-bromo-4-methylpentyl)-1-methoxy-2-(3-methoxypropoxy)benzene;(2R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl bromide;4-(2-(bromomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene;1-Methoxy-2-(3-methoxypropoxy)-4-[(3-bromo-(2R)-isopropyl)propyl]benzene;(R)-4-[2-(BroMoMethyl)-3-Methylbutyl]-1-Methoxy-2-(3-Methoxypropoxy)benzene;2-(3-methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene
CBNumber:
CB91094179
Molecular Formula:
C17H27BrO3
Molecular Weight:
359.3
MDL Number:
MFCD10566721
MOL File:
172900-69-5.mol
MSDS File:
SDS
Last updated:2026-05-28 04:35:09
Product description Number Pack Size Price
1-Methoxy-2-(3-methoxypropoxy)-4-[(3-bromo-(2R)-isopropyl)propyl]benzene 016254 10mg $403
2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene 090256 1.00g $79
2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene 090256 5.00g $263
2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene 090256 10.00g $468
2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene 96% AA00ADZI 250mg $31
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2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene Properties

Melting point 52-53 °C
Boiling point 398.8±32.0 °C(Predicted)
Density 1.173
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Dichloromethane, Ethyl Acetate,
form Solid
color White
CAS DataBase Reference 172900-69-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 016254 1-Methoxy-2-(3-methoxypropoxy)-4-[(3-bromo-(2R)-isopropyl)propyl]benzene 172900-69-5 10mg $403 2026-06-03 Buy
Matrix Scientific 090256 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene 172900-69-5 1.00g $79 2026-05-18 Buy
Matrix Scientific 090256 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene 172900-69-5 5.00g $263 2026-05-18 Buy
Matrix Scientific 090256 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene 172900-69-5 10.00g $468 2026-05-18 Buy
aablocks AA00ADZI 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene 96% 172900-69-5 250mg $31 2026-05-28 Buy
Product number Packaging Price Buy
016254 10mg $403 Buy
090256 1.00g $79 Buy
090256 5.00g $263 Buy
090256 10.00g $468 Buy
AA00ADZI 250mg $31 Buy

2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Intermediate in the preparation of Aliskiren.

Synthesis

Benzenepropanol, 4-methoxy-3-(3-methoxypropoxy)-b-(1-methylethyl)-, (bR)-

172900-70-8

2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene

172900-69-5

Example 1 Synthesis of (R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl bromide: (R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutanol (14.82 g, 50 mmol) was dissolved in N,N-dimethylformamide (234 mL), and phosphorus tribromide ( 14.33 g, 50 mmol) and the reaction temperature was controlled at 20 °C. The reaction mixture was stirred at 20 °C for 8 hours. After the reaction was completed, it was cooled to room temperature and the reaction solution was slowly poured into water (702 mL) and extracted three times with hexane. The hexane layers were combined and washed twice each with saturated sodium bicarbonate solution and saturated sodium chloride solution in turn. The organic layer was dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated to give 17 g of oily product. Methanol (51 mL) was added to the oily product and the product was crystallized at a controlled temperature of -10°C. The crystals were collected by filtration. The crystals were collected by filtration and dried under vacuum at room temperature to give 14.3 g of white solid in 79.6% yield, melting point 51-53 °C, chiral purity ≥99.9%.1H NMR (ppm, CDCl3): δ 6.72-6.81 (m, 3H), 4.11 (t, J = 6.4 Hz, 2H), 3.84 (s, 3H), 3.58 (t, J = 6.4 Hz, 2H), 3.42 (dd, J = 4.5, 10.2 Hz, 1H), 3.36 (s, 3H), 3.30 (dd, J = 4.5, 10.2 Hz, 1H), 2.77 (dd, J = 4.8, 13.8 Hz, 1H), 2.48 (dd, J = 4.8, 13.8 Hz, 1H), 2.11 (m, 2H ), 1.86 (m, 1H), 1.60 (m, 1H), 0.99 (m, 6H).

References

[1] Helvetica Chimica Acta, 2003, vol. 86, # 8, p. 2848 - 2870
[2] Tetrahedron Letters, 2005, vol. 46, # 37, p. 6337 - 6340
[3] Patent: US2013/231509, 2013, A1. Location in patent: Paragraph 0021-0022
[4] Patent: WO2011/148392, 2011, A1. Location in patent: Page/Page column 62
[5] Patent: WO2012/78147, 2012, A1. Location in patent: Page/Page column 19-20

2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene synthesis

4383-06-6
172900-69-5
Synthesis of 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene from 3-Hydroxy-4-methoxybenzyl alcohol

2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene Preparation Products And Raw materials

Raw materials

Benzenepropanol, 4-methoxy-3-(3-methoxypropoxy)-b-(1-methylethyl)-, (bR)- N,N-Dimethylformamide Phosphorus oxybromide

Preparation Products

Benzene, 4-[2-(iodoMethyl)-3-Methylbutyl]-1-Methoxy-2-(3-Methoxypropoxy)-, (R)- (2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine

2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene Suppliers

Global( 65)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52704 58
changzhou huayang technology co., ltd 		+8615250961469 2571773637@qq.com China 9653 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
Golden Pharma Co., Limited 		+undefined18958062155 sales@zjgoldpharm.com China 5899 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49962 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501; +undefined18621343501 product@acmec-e.com China 33324 58
Supplier Advantage
career henan chemical co 		58
Alchem Pharmtech,Inc. 		58
SIMAGCHEM CORP 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
changzhou huayang technology co., ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Golden Pharma Co., Limited 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
GIHI CHEMICALS CO.,LIMITED 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58

View Lastest Price from 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene pictures 2019-07-06 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene
172900-69-5
 $7.00 1kg 99% 100KG Career Henan Chemical Co

172900-69-5(2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene)Related Search:

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METHOXYTRIMETHYLSILANE (Trifluoromethoxy)benzene POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE 3-Amino-2,2-dimethylpropionamide Aliskiren inter-8
Aliskiren inter-11 1-(((S)-2-(Bromomethyl)-3-methylbutoxy)methyl)benzene 4-Pentenamide, 5-chloro-N,N-dimethyl-2-(1-methylethyl)-, (2S,4E)- Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)- 4-Pentenoic acid, 5-chloro-2-(1-methylethyl)-, (2S,4E)-
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(2R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl bromide 2-(3-methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene Benzene, 4-[(2R)-2-(bromomethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)- 4-[(2R)-2-(Bromomethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene 4-(5-bromo-4-methylpentyl)-1-methoxy-2-(3-methoxypropoxy)benzene 4-(2-(bromomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene 1-Methoxy-2-(3-methoxypropoxy)-4-[(3-bromo-(2R)-isopropyl)propyl]benzene 2-(3-METHOXYPROPOXY)-4-((4R)-2-(BROMOMETHYL)-3-METHYLBUTYL)-1-METHOXYBENZENE 2-(3-Methoxypropoxy)-4-((R)-2-(broMoMethyl)-3 (R)-4-[2-(BroMoMethyl)-3-Methylbutyl]-1-Methoxy-2-(3-Methoxypropoxy)benzene -1-methoxybenzene 2-(3-Methoxypropoxy) 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1... 172900-69-5 C17H27BrO3 Aromatics Chiral Reagents