3-Pyridylboronic acid
- CAS No.
- 1692-25-7
- Chemical Name:
- 3-Pyridylboronic acid
- Synonyms
- PYRIDIN-3-YLBORONIC ACID;3-PYRIDINEBORONIC ACID;PYRIDINE-3-BORONIC ACID;3-PyridyL;3-PYRIDINYLBORONIC ACID;DFD3;AKOS BRN-0272;Pyridine-3-acid;3-Boronopyridine;RARECHEM AH PB 0251
- CBNumber:
- CB9111390
- Molecular Formula:
- C5H6BNO2
- Molecular Weight:
- 122.92
- MDL Number:
- MFCD00674177
- MOL File:
- 1692-25-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Pyridinylboronic acid ≥95.0% | 512125 | 1g | $90.06 |
| 3-Pyridinylboronic acid ≥95.0% | 512125 | 5g | $259.02 |
| 3-Pyridylboronic Acid (contains varying amounts of Anhydride) | P1673 | 1g | $20 |
| 3-Pyridylboronic Acid (contains varying amounts of Anhydride) | P1673 | 5g | $51 |
| 3-Pyridinylboronic acid ≥95.0% | 512125 | 25g | $268 |
| More product size | |||
| Melting point | >300 °C (lit.) |
|---|---|
| Boiling point | 308.8±34.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Slightly soluble in methanol. |
| form | Powder, Crystals and/or Chunks |
| pka | 4.00±0.10(Predicted) |
| color | White to yellow-orange |
| BRN | 471943 |
| InChI | InChI=1S/C5H6BNO2/c8-6(9)5-2-1-3-7-4-5/h1-4,8-9H |
| InChIKey | ABMYEXAYWZJVOV-UHFFFAOYSA-N |
| SMILES | C1=NC=CC=C1B(O)O |
| CAS DataBase Reference | 1692-25-7(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn,Xi,C,F | |||||||||
| Risk Statements | 36/37/38-22-34-11 | |||||||||
| Safety Statements | 36/37/39-3-26-45-16 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | IRRITANT, KEEP COLD | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
3-Pyridylboronic acid price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 512125 | 3-Pyridinylboronic acid ≥95.0% | 1692-25-7 | 1g | $90.06 | 2025-07-31 | Buy |
| Sigma-Aldrich | 512125 | 3-Pyridinylboronic acid ≥95.0% | 1692-25-7 | 5g | $259.02 | 2025-07-31 | Buy |
| TCI Chemical | P1673 | 3-Pyridylboronic Acid (contains varying amounts of Anhydride) | 1692-25-7 | 1g | $20 | 2025-07-31 | Buy |
| TCI Chemical | P1673 | 3-Pyridylboronic Acid (contains varying amounts of Anhydride) | 1692-25-7 | 5g | $51 | 2025-07-31 | Buy |
| Sigma-Aldrich | 512125 | 3-Pyridinylboronic acid ≥95.0% | 1692-25-7 | 25g | $268 | 2025-07-31 | Buy |
3-Pyridylboronic acid Chemical Properties,Uses,Production
Chemical Properties
Light Yellow Powder
Uses
Boronic acid derivatives and their binding affinities with diols.
Uses
3-Pyridylboronic acid is a reagent used for• ;Phosphine-free Suzuki-Miyaura cross-coupling reactions
1 ;Regioselective Suzuki-Miyaura coupling and tandem palladium-catalyzed intramolecular aminocarbonylation and annulation
2 ;N-arylation using copper acetylacetonate catalyst
3 ;Copper-mediated cyanation and regioselective cyanation of electron-rich benzenes
4 Reagent use in Preparation of • ;New linear poly(phenylpyridyl) chains by Suzuki coupling
5 ;Oligopyridyl foldamers as mimics of a-helix twist
6 ;Many highly significant therapeutic enzymatic and kinase inhibitors and r
Uses
suzuki reaction
Synthesis Reference(s)
The Journal of Organic Chemistry, 64, p. 3846, 1999 DOI: 10.1021/jo9819279
Tetrahedron Letters, 43, p. 4285, 2002
Synthesis
626-55-1
5419-55-6
1692-25-7
The general procedure for the synthesis of pyridine-3-boronic acid from 3-bromopyridine and triisopropyl borate was as follows: first, pyridine-3-boronic acid (1-6) was prepared by subsequent hydrolysis via an appropriate esterification reaction according to the method of Cai et al. (Tetrahedron Lett. 43: 4285-4287, 2002). This was done as follows: 85 mL of toluene was added to a 500 mL three-necked flask, cooled to below -60°C, and then 1.6 M of n-BuLi hexane solution (48.6 mL, 77.8 mmol) was added dropwise over 10 min. After the internal temperature reached -60°C, a toluene solution (30 mL) of 3-bromopyridine (6.8 mL, 70.7 mmol) was slowly added dropwise to keep the internal temperature below -50°C. At this point, a brownish-black solid precipitated, and the resulting slurry was stirred for 20 min. Next, 30 mL of THF was added dropwise to keep the internal temperature below -50°C and stirring was continued for 15 min. Subsequently, triisopropyl borate (19.6 mL, 84.9 mmol) was added all at once via syringe. The solution was slowly heated to -15°C, and the reaction was quenched with 2.7 N aqueous HCl (70.0 mL) and transferred to a partition funnel. The aqueous layer was separated and the organic layer was washed with 10 mL of water. The combined aqueous layers were neutralized to pH 7 with 10 N NaOH aqueous solution and extracted with THF (200 mL x 1, 125 mL x 2). The organic phases were combined and concentrated under reduced pressure. The residue was dissolved in THF/CH3OH (1:1, 140 mL), filtered and diluted with CH3CN to 300 mL.The solvent was converted to CH3CN by distillation and concentrated to 100 mL.The solids were collected by filtration to afford pyridine-3-boronic acid 1 (6.4 g, 73% yield) as an off-white solid. The product was confirmed by 1H NMR (CD3OD): δ 8.64 (br s, 1H), 8.50 (m, 1H), 8.38 (br s, 1H), 7.65 (br s, 1H). The product can be used directly in Suzuki cross-coupling reaction.
References
[1] Patent: WO2005/66162, 2005, A1. Location in patent: Page/Page column 92
[2] Organic Syntheses, 2005, vol. 81, p. 89 - 97
3-Pyridylboronic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8772 | 58 |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1085 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | info@spring-chem.com | China | 2068 | 57 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13456 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
View Lastest Price from 3-Pyridylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-10-16 | 3-Pyridylboronic acid
1692-25-7
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-10-11 | 3-Pyridylboronic acid
1692-25-7
|
US $10.00 / KG | 100KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-08-08 | 3-Pyridylboronic acid
1692-25-7
|
US $0.00 / Kg/Drum | 1Kg/Drum | 99% | 5000KG | Sichuan Zhuoyu Yantang Technology Co., Ltd. |
-
- 3-Pyridylboronic acid
1692-25-7
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 3-Pyridylboronic acid
1692-25-7
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-Pyridylboronic acid
1692-25-7
- US $0.00 / Kg/Drum
- 99%
- Sichuan Zhuoyu Yantang Technology Co., Ltd.
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