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6-Methyl-4-phenylchroman-2-one

6-Methyl-4-phenylchroman-2-one Structure
6-Methyl-4-phenylchroman-2-one structure
CAS No.
40546-94-9
Chemical Name:
6-Methyl-4-phenylchroman-2-one
Synonyms
LACTONE IMPURITY;Tolterodine impurity Z09;forTolterodine-L-tartrate;Tolterodine interMediates;Tolterodine Lactone IMpurity;6-METHYL-4-PHENYL-CHROMAN-ONE;6-Methyl-4-phenyl-2-chromanone;6-METHYL-4-PHENYLCHROMAN-2-ONE;6-Methy1-4-phenyl-chroMan-2-one;6-Methyl-4-phenyl-2-chromanone>
CBNumber:
CB9120255
Molecular Formula:
C16H14O2
Molecular Weight:
238.28
MDL Number:
MFCD03695019
MOL File:
40546-94-9.mol
MSDS File:
SDS
Last updated:2026-05-28 03:57:37
Product description Number Pack Size Price
6-Methyl-4-Phenylchromanone Pharmaceutical Analytical Impurity (PAI) 1A01060 25mg $674
6-Methyl-4-phenyl-2-chromanone >98.0%(GC) M2093 5g $33
6-Methyl-4-phenyl-2-chromanone >98.0%(GC) M2093 25g $129
rac-6-Methyl-4-phenylchroman-2-one TRC-M326450-500MG 500mg $135
rac-6-Methyl-4-phenylchroman-2-one TRC-M326450-100MG 100mg $84
More product size
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6-Methyl-4-phenylchroman-2-one Properties

Melting point 68-70°C
Boiling point 230°C/16mmHg(lit.)
Density 1.166±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
Major Application pharmaceutical
InChI 1S/C16H14O2/c1-11-7-8-15-14(9-11)13(10-16(17)18-15)12-5-3-2-4-6-12/h2-9,13H,10H2,1H3
InChIKey SUHIZPDCJOQZLN-UHFFFAOYSA-N
SMILES CC1=CC=C(O2)C(C(C3=CC=CC=C3)CC2=O)=C1
CAS DataBase Reference 40546-94-9(CAS DataBase Reference)
UNSPSC Code 41116100
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P501-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405
WGK Germany  WGK 3
HS Code  2932.20.4500
Storage Class 11 - Combustible Solids
Hazard Classifications Skin Sens. 1
REACH Registrations Active

6-Methyl-4-phenylchroman-2-one price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1A01060 6-Methyl-4-Phenylchromanone Pharmaceutical Analytical Impurity (PAI) 40546-94-9 25mg $674 2026-04-30 Buy
TCI Chemical M2093 6-Methyl-4-phenyl-2-chromanone >98.0%(GC) 40546-94-9 5g $33 2026-04-30 Buy
TCI Chemical M2093 6-Methyl-4-phenyl-2-chromanone >98.0%(GC) 40546-94-9 25g $129 2026-04-30 Buy
TRC TRC-M326450-500MG rac-6-Methyl-4-phenylchroman-2-one 40546-94-9 500mg $135 2026-06-03 Buy
TRC TRC-M326450-100MG rac-6-Methyl-4-phenylchroman-2-one 40546-94-9 100mg $84 2026-06-03 Buy
Product number Packaging Price Buy
1A01060 25mg $674 Buy
M2093 5g $33 Buy
M2093 25g $129 Buy
TRC-M326450-500MG 500mg $135 Buy
TRC-M326450-100MG 100mg $84 Buy

6-Methyl-4-phenylchroman-2-one Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Intermediate in the production of Tolterodine.

Synthesis

p-Cresol

106-44-5

Cinnamic acid

621-82-9

6-Methyl-4-phenylchroman-2-one

40546-94-9

The general procedure for the synthesis of 6-methyl-4-phenylbenzodihydropyran-2-one from p-cresol and trans-cinnamic acid is as follows: a mixture of 0.5 kg cinnamic acid, 0.401 kg p-cresol and 2.2 L xylene was stirred for 15 minutes. 0.132 kg of concentrated sulfuric acid was slowly added under continuous stirring. After addition of the acid, the reaction mixture was stirred at 140-145 °C for the reaction. After completion of the reaction, the reaction was cooled to room temperature and then washed with 1.0 L of deionized water. The reaction mixture was further cooled to 10-15 °C, and 0.5 N NaOH solution was added to deionized water, and the reaction mixture was added dropwise and stirred at the same temperature for 1 hour. The organic layer was separated and washed with deionized water. The organic layer was completely distilled under reduced pressure (30-40 mmHg) to give 3,4-dihydro-6-methyl-4-phenyl-2H-benzopyran-2-one (Yield: 0.78 kg, Yield: 97%).HPLC purity: > 95%.

References

[1] Patent: WO2010/46801, 2010, A2. Location in patent: Page/Page column 15
[2] Research on Chemical Intermediates, 2016, vol. 42, # 7, p. 6407 - 6422
[3] Organic Process Research and Development, 2005, vol. 9, # 3, p. 314 - 318
[4] Tetrahedron Letters, 2012, vol. 53, # 33, p. 4469 - 4472
[5] Tetrahedron, 2014, vol. 70, # 34, p. 5221 - 5233

6-Methyl-4-phenylchroman-2-one synthesis

106-44-5
621-82-9
40546-94-9
Synthesis of 6-Methyl-4-phenylchroman-2-one from p-Cresol and Cinnamic acid

6-Methyl-4-phenylchroman-2-one Preparation Products And Raw materials

Raw materials

4-methylphenyl 3-phenylacrylate 2-(methoxymethoxy)-5-methylbenzaldehyde 6-Methyl-4-phenylcoumarin ethyl (E)-3-(2-hydroxy-5-methylphenyl)acrylate 2,4,6-Triphenylboroxin
trans-Cinnamic acid p-Cresol Ethyl cinnamate Cinnamoyl chloride Cinnamic acid

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Preparation Products

2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol

6-Methyl-4-phenylchroman-2-one Suppliers

Global( 176)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5228 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52705 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12373 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co,.LTD 		58
Capot Chemical Co.,Ltd. 		60
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
SIMAGCHEM CORP 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
sgtlifesciences pvt ltd 		58

View Lastest Price from 6-Methyl-4-phenylchroman-2-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-Methyl-4-phenylchroman-2-one pictures 2026-05-28 6-Methyl-4-phenylchroman-2-one
40546-94-9
 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
6-Methyl-4-phenylchroman-2-one pictures 2019-12-25 6-Methyl-4-phenylchroman-2-one
40546-94-9
 $1.00 1KG 99% 200kg Career Henan Chemical Co

6-Methyl-4-phenylchroman-2-one Spectrum

6-Methyl-4-phenylchroman-2-one(40546-94-9)1HNMR

40546-94-9(6-Methyl-4-phenylchroman-2-one)Related Search:

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Dichloromethylphenylsilane Kresoxim-methyl Trimethylphenylammonium chloride Mesotrione Methyltriphenylphosphonium bromide
Thiophanate-methyl 4-Methyl-2-pentanone Methyl

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forTolterodine-L-tartrate 6-METHYL-4-PHENYL-3,4-DIHYDRO-2H-1-BENZOPYRAN-2-ONE 6-METHYL-4-PHENYL-CHROMAN-ONE 6-METHYL-4-PHENYL-3,4-DIHYDRO-2H-1-BENZOPYRAN 6-Methyl-4-phenyl-2-chromanone Dihydro methyl phenyl benzopyran one rac-6-Methyl-4-phenylchroMan-2-one 2H-1-Benzopyran-2-one, 3,4-dihydro-6-Methyl-4-phenyl- 6-Methy1-4-phenyl-chroMan-2-one 6-Methyl-4-phenylchroman-2-one 3,4-Dihydro-6-methyl-4-phenyl-2H-1-benzopyran-2-one 6-Methyl-4-phenyl-3,4-dihydro-1-benzopyran-2-one Tolterodine interMediates Tolterodine Lactone IMpurity 6-METHYL-4-PHENYLCHROMAN-2-ONE 3,4-DIHYDRO-6-METHYL-4-PHENYL-2H-1-BENZOPYRAN-2-ONE 6-Methyl-4-phenyl-3,4-dihydrovanillin 6-Methyl-4-Phenyl-3,4-Dihydrovanillin(ForTolterodine-L-Tartrate) 6-Methyl-4-phenyl-2-chromanone> Tolterodine Dihydro Benzopyranone Impurity Tolterodine Dihydro Benzopyranone Impurity/ Tolterodine Lactone Impurity Racemate Tolterodine Lactone Impurity Racemate LACTONE IMPURITY Tolterodine impurity Z09 6-methyl-4-phenyltryptophan-2-one 40546-94-9 C16H14O2 Benzenes (intermediate of tolterodine tartrate) TOLTERODINE TARTRATE (intermeidate of tolterodine) API intermediates Medicine intermediate Aromatics Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals