6-Methyl-4-phenylchroman-2-one
- CAS No.
- 40546-94-9
- Chemical Name:
- 6-Methyl-4-phenylchroman-2-one
- Synonyms
- LACTONE IMPURITY;Tolterodine impurity Z09;forTolterodine-L-tartrate;Tolterodine interMediates;Tolterodine Lactone IMpurity;6-METHYL-4-PHENYL-CHROMAN-ONE;6-Methyl-4-phenyl-2-chromanone;6-METHYL-4-PHENYLCHROMAN-2-ONE;6-Methy1-4-phenyl-chroMan-2-one;6-Methyl-4-phenyl-2-chromanone>
- CBNumber:
- CB9120255
- Molecular Formula:
- C16H14O2
- Molecular Weight:
- 238.28
- MDL Number:
- MFCD03695019
- MOL File:
- 40546-94-9.mol
| Product description | Number | Pack Size | Price |
| 6-Methyl-4-Phenylchromanone Pharmaceutical Analytical Impurity (PAI) | 1A01060 | 25mg | $646 |
| 6-Methyl-4-phenyl-2-chromanone >98.0%(GC) | M2093 | 5g | $29 |
| 6-Methyl-4-phenyl-2-chromanone >98.0%(GC) | M2093 | 25g | $115 |
| rac-6-Methyl-4-phenylchroman-2-one | M326450 | 5g | $180 |
| rac-6-Methyl-4-phenylchroman-2-one | M326450 | 50mg | $50 |
| More product size | |||
| Melting point | 68-70°C |
|---|---|
| Boiling point | 230°C/16mmHg(lit.) |
| Density | 1.166±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 40546-94-9(CAS DataBase Reference) |
| UNSPSC Code | 41116100 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P501-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405 |
| HS Code | 2932.20.4500 |
6-Methyl-4-phenylchroman-2-one price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1A01060 | 6-Methyl-4-Phenylchromanone Pharmaceutical Analytical Impurity (PAI) | 40546-94-9 | 25mg | $646 | 2025-07-31 | Buy |
| TCI Chemical | M2093 | 6-Methyl-4-phenyl-2-chromanone >98.0%(GC) | 40546-94-9 | 5g | $29 | 2025-07-31 | Buy |
| TCI Chemical | M2093 | 6-Methyl-4-phenyl-2-chromanone >98.0%(GC) | 40546-94-9 | 25g | $115 | 2025-07-31 | Buy |
| TRC | M326450 | rac-6-Methyl-4-phenylchroman-2-one | 40546-94-9 | 5g | $180 | 2021-12-16 | Buy |
| TRC | M326450 | rac-6-Methyl-4-phenylchroman-2-one | 40546-94-9 | 50mg | $50 | 2021-12-16 | Buy |
6-Methyl-4-phenylchroman-2-one Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Intermediate in the production of Tolterodine.
Synthesis
106-44-5
621-82-9
40546-94-9
The general procedure for the synthesis of 6-methyl-4-phenylbenzodihydropyran-2-one from p-cresol and trans-cinnamic acid is as follows: a mixture of 0.5 kg cinnamic acid, 0.401 kg p-cresol and 2.2 L xylene was stirred for 15 minutes. 0.132 kg of concentrated sulfuric acid was slowly added under continuous stirring. After addition of the acid, the reaction mixture was stirred at 140-145 °C for the reaction. After completion of the reaction, the reaction was cooled to room temperature and then washed with 1.0 L of deionized water. The reaction mixture was further cooled to 10-15 °C, and 0.5 N NaOH solution was added to deionized water, and the reaction mixture was added dropwise and stirred at the same temperature for 1 hour. The organic layer was separated and washed with deionized water. The organic layer was completely distilled under reduced pressure (30-40 mmHg) to give 3,4-dihydro-6-methyl-4-phenyl-2H-benzopyran-2-one (Yield: 0.78 kg, Yield: 97%).HPLC purity: > 95%.
References
[1] Patent: WO2010/46801, 2010, A2. Location in patent: Page/Page column 15
[2] Research on Chemical Intermediates, 2016, vol. 42, # 7, p. 6407 - 6422
[3] Organic Process Research and Development, 2005, vol. 9, # 3, p. 314 - 318
[4] Tetrahedron Letters, 2012, vol. 53, # 33, p. 4469 - 4472
[5] Tetrahedron, 2014, vol. 70, # 34, p. 5221 - 5233
6-Methyl-4-phenylchroman-2-one Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5251 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
View Lastest Price from 6-Methyl-4-phenylchroman-2-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-26 | 6-Methyl-4-phenylchroman-2-one
40546-94-9
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2019-12-25 | 6-Methyl-4-phenylchroman-2-one
40546-94-9
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 6-Methyl-4-phenylchroman-2-one
40546-94-9
- US $5.00-2.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 6-Methyl-4-phenylchroman-2-one
40546-94-9
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
