3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 7-[3-[(3S,4S)-9-ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxo-3-phorbinyl]-1-oxopropoxy]-4-hydroxy-N,N,N-trimethyl-10-oxo-, inner salt, 4-oxide, (7R)-
![3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 7-[3-[(3S,4S)-9-ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxo-3-phorbinyl]-1-oxopropoxy]-4-hydroxy-N,N,N-trimethyl-10-oxo-, inner salt, 4-oxide, (7R)- Structure](CAS/20211123/GIF/1287795-07-6.gif)
- CAS No.
- 1287795-07-6
- Chemical Name:
- 3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 7-[3-[(3S,4S)-9-ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxo-3-phorbinyl]-1-oxopropoxy]-4-hydroxy-N,N,N-trimethyl-10-oxo-, inner salt, 4-oxide, (7R)-
- Synonyms
- 1-Palmitoyl-2-Pyropheophorbide a-sn-glycero-3-PC;3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 7-[3-[(3S,4S)-9-ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxo-3-phorbinyl]-1-oxopropoxy]-4-hydroxy-N,N,N-trimethyl-10-oxo-, inner salt, 4-oxide, (7R)-
- CBNumber:
- CB913369502
- Molecular Formula:
- C57H82N5O9P
- Molecular Weight:
- 1012.27
- MDL Number:
- MOL File:
- 1287795-07-6.mol
3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 7-[3-[(3S,4S)-9-ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxo-3-phorbinyl]-1-oxopropoxy]-4-hydroxy-N,N,N-trimethyl-10-oxo-, inner salt, 4-oxide, (7R)- Chemical Properties,Uses,Production
Description
1-Palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC is a phospholipid-porphyrin conjugate that is composed of phosphatidylcholine containing palmitic acid (Item No. 10006627) at the sn-1 position and the photosensitizer pyropheophorbide a (Item No. 21371) at the sn-2 position.1 Lipid nanoparticles (LNPs) containing 1-palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC and encapsulating FAM-labeled siRNA are dissociated under irradiation with near-infrared light (NIR) in PC3-Luc6 cells. 1-Palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC then enters the endolysosomal membrane and generates reactive oxygen species (ROS), which disrupt the membrane and allow the release of FAM-labeled siRNA into the cytosol. 1-Palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC-stabilized nanoemulsions loaded with the mitotic inhibitor paclitaxel (Item No. 10461), combined with laser irradiation, reduce tumor growth and increase survival in a KB squamous cell carcinoma mouse xenograft model.2WARNING This product is not for human or veterinary use.
References
[1] YULIN MO, GANG ZHENG* Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles[J]. ACS Nano, 2023, 17 5: 4688-4703. DOI: 10.1021/acsnano.2c10936
[2] ENLING CHANG. Porphyrin-lipid stabilized paclitaxel nanoemulsion for combined photodynamic therapy and chemotherapy.[J]. Journal of Nanobiotechnology, 2021: 154. DOI: 10.1186/s12951-021-00898-1
3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 7-[3-[(3S,4S)-9-ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxo-3-phorbinyl]-1-oxopropoxy]-4-hydroxy-N,N,N-trimethyl-10-oxo-, inner salt, 4-oxide, (7R)- Preparation Products And Raw materials
Raw materials
Preparation Products
3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 7-[3-[(3S,4S)-9-ethenyl-14-ethyl-4,8,13,18-tetramethyl-20-oxo-3-phorbinyl]-1-oxopropoxy]-4-hydroxy-N,N,N-trimethyl-10-oxo-, inner salt, 4-oxide, (7R)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Easy CDMO Co.,Ltd | 021-61734564 13854185395; | info@easycdmo.com | China | 10030 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 31138 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
