1-N-Boc-3-Cyanopyrrolidine
- CAS No.
- 476493-40-0
- Chemical Name:
- 1-N-Boc-3-Cyanopyrrolidine
- Synonyms
- TERT-BUTYL 3-CYANOPYRROLIDINE-1-CARBOXYLATE;1-Boc-3-cyanopyrrolidine;N-Boc-3-cyanopyrrolidine;N-1-BOC-3-CYANOPYRROLIDINE;1-N-BOC-3-CYANO-PYRROLIDINE;1,1-Dimethylethyl 3-cyano-1-pyrrolidinecarboxylate;3-CYANO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Pyrrolidinecarboxylic acid, 3-cyano-, 1,1-dimethylethyl ester
- CBNumber:
- CB9135859
- Molecular Formula:
- C10H16N2O2
- Molecular Weight:
- 196.25
- MDL Number:
- MFCD03001709
- MOL File:
- 476493-40-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-BOC-3-CYANO-PYRROLIDINE 97% | B66770 | 1G | $39 |
| 1-BOC-3-CYANO-PYRROLIDINE 97% | B66770 | 5G | $119 |
| 1-BOC-3-CYANO-PYRROLIDINE 97% | B66770 | 25G | $410 |
| 1-N-Boc-3-cyanopyrrolidine 97% | OR480753 | 1g | $39 |
| 1-N-Boc-3-cyanopyrrolidine 97% | OR480753 | 5g | $100 |
| More product size | |||
| Boiling point | 307.9±35.0 °C(Predicted) |
|---|---|
| Density | 1.08±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | -3.73±0.40(Predicted) |
| form | solid |
| color | Pale yellow |
| CAS DataBase Reference | 476493-40-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319 | |||||||||
| Precautionary statements | P280h-P305+P351+P338 | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RIDADR | 3439 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
1-N-Boc-3-Cyanopyrrolidine price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | B66770 | 1-BOC-3-CYANO-PYRROLIDINE 97% | 476493-40-0 | 1G | $39 | 2026-04-30 | Buy |
| AstaTech | B66770 | 1-BOC-3-CYANO-PYRROLIDINE 97% | 476493-40-0 | 5G | $119 | 2026-04-30 | Buy |
| AstaTech | B66770 | 1-BOC-3-CYANO-PYRROLIDINE 97% | 476493-40-0 | 25G | $410 | 2026-04-30 | Buy |
| Apolloscientific | OR480753 | 1-N-Boc-3-cyanopyrrolidine 97% | 476493-40-0 | 1g | $39 | 2026-06-04 | Buy |
| Apolloscientific | OR480753 | 1-N-Boc-3-cyanopyrrolidine 97% | 476493-40-0 | 5g | $100 | 2026-06-04 | Buy |
1-N-Boc-3-Cyanopyrrolidine Chemical Properties,Uses,Production
Uses
1-N-Boc-3-cyanopyrrolidine is used to prepare aroyl-substituted pyrrolidines with monoamine reuptake inhibition activities.
Synthesis
773837-37-9
141699-57-2
476493-40-0
A solution was prepared from tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate (2.65 g, 10 mmol) and sodium cyanide (2.5 g, 50 mmol) in N,N-dimethylformamide (100 mL). The reaction mixture was stirred at 100°C for 16 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was poured into water and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure and the resulting residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate=5:1) to afford 1-N-Boc-3-cyanopyrrolidine (1.92 g, 98% yield).
References
[1] Patent: CN107474024, 2017, A. Location in patent: Paragraph 0385; 0392; 0393; 0394
[2] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 59; 60
1-N-Boc-3-Cyanopyrrolidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49969 | 58 |
View Lastest Price from 1-N-Boc-3-Cyanopyrrolidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 1-N-Boc-3-Cyanopyrrolidine
476493-40-0
|
1KG | 98% | 150KG | Career Henan Chemical Co |
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- 1-N-Boc-3-Cyanopyrrolidine
476493-40-0
- $0.00
- 98%
- Career Henan Chemical Co
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